5'AMP-activated protein kinase alpha deficiency enhances stress-induced apoptosis in BHK and PC12 cells

scientific article published on March 2007

5'AMP-activated protein kinase alpha deficiency enhances stress-induced apoptosis in BHK and PC12 cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1582-4934.2007.00023.X
P932PMC publication ID3822827
P698PubMed publication ID17488477
P5875ResearchGate publication ID6343883

P50authorRory J. McCrimmonQ42317155
P2093author name stringDaniel F Schorderet
Robert S Sherwin
Werner K Gurr
Margaret M Shaw
P2860cites workThe tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressQ24633606
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.Q32043995
Glucose deprivation induces mitochondrial dysfunction and oxidative stress in PC12 cell line.Q33187153
Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinaseQ33202703
ATP converts necrosis to apoptosis in oxidant-injured endothelial cells.Q34478399
Insulin and ischemia stimulate glycolysis by acting on the same targets through different and opposing signaling pathwaysQ34977070
Malonyl-CoA and AMP-activated protein kinase: an expanding partnershipQ35584830
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injuryQ37286204
AMPK-beta1 subunit is a p53-independent stress responsive protein that inhibits tumor cell growth upon forced expressionQ38354203
Ganciclovir and penciclovir, but not acyclovir, induce apoptosis in herpes simplex virus thymidine kinase-transformed baby hamster kidney cellsQ40637172
Control of apoptosis by the cellular ATP levelQ40940073
Intracellular ATP levels determine cell death fate by apoptosis or necrosis.Q41110278
Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptorsQ43717023
AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivationQ43772807
Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activationQ43833571
Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosisQ44970252
Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategyQ70147645
Transcription factor DNA binding activity in PC12 cells undergoing apoptosis after glucose deprivationQ71981066
Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cellsQ74255134
Inhibition of glucocorticoid-induced apoptosis with 5-aminoimidazole-4-carboxamide ribonucleoside, a cell-permeable activator of AMP-activated protein kinaseQ74311172
P433issue2
P304page(s)286-298
P577publication date2007-03-01
P1433published inJournal of Cellular and Molecular MedicineQ1524063
P1476title5'AMP-activated protein kinase alpha deficiency enhances stress-induced apoptosis in BHK and PC12 cells
P478volume11

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cites work (P2860)
Q58669677AMPK Activation of PGC-1α/NRF-1-Dependent SELENOT Gene Transcription Promotes PACAP-Induced Neuroendocrine Cell Differentiation Through Tolerance to Oxidative Stress
Q39228559AMPK inhibition enhances apoptosis in MLL-rearranged pediatric B-acute lymphoblastic leukemia cells
Q37430578AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.
Q39733339AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells
Q36543710Autophagy controls p38 activation to promote cell survival under genotoxic stress
Q36642909BML-275, an AMPK inhibitor, induces DNA damage, G2/M arrest and apoptosis in human pancreatic cancer cells
Q43069620Compound C sensitizes Caki renal cancer cells to TRAIL-induced apoptosis through reactive oxygen species-mediated down-regulation of c-FLIPL and Mcl-1.
Q36383300Effect of metformin on the proliferation, migration, and MMP-2 and -9 expression of human umbilical vein endothelial cells
Q43117907Inhibition of AMP-activated protein kinase pathway sensitizes human leukemia K562 cells to nontoxic concentration of doxorubicin.
Q38748168Marein protects against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12 cells
Q35130191Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease
Q35042551Susceptibility to ATP depletion of primary proximal tubular cell cultures derived from mice lacking either the α1 or the α2 isoform of the catalytic domain of AMPK.
Q38165133The multifaceted activities of AMPK in tumor progression--why the "one size fits all" definition does not fit at all?
Q93173728WIPI2 depletion inhibits the growth of hepatocellular carcinoma cells through the AMPK signaling pathway
Q41491502p21(WAF1/CIP1) Expression is Differentially Regulated by Metformin and Rapamycin

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