Molecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells

scientific article published on 14 April 2016

Molecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells is …
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scholarly articleQ13442814

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P356DOI10.1038/SREP24296
P932PMC publication ID4830966
P698PubMed publication ID27075531

P2093author name stringAhuvit David
Shai Izraeli
Assaf Friedler
Hadar Amartely
Noa Rabinowicz
Mai Shamir
P2860cites workThe STIL protein contains intrinsically disordered regions that mediate its protein-protein interactions.Q53090758
Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar materialQ71139760
Characteristic features of amino acid residues in coiled-coil protein structuresQ80592981
The human microcephaly protein STIL interacts with CPAP and is required for procentriole formationQ24294326
STIL is required for centriole duplication in human cellsQ24305503
SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cellsQ24338767
Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemiaQ24594559
dbSNP: the NCBI database of genetic variationQ24608672
The transition from meiotic to mitotic spindle assembly is gradual during early mammalian developmentQ24622331
How do cilia organize signalling cascades?Q27005693
Coiled-coil proteins facilitated the functional expansion of the centrosomeQ27322205
Structural Basis of the 9-Fold Symmetry of CentriolesQ27666762
SAS-6 coiled-coil structure and interaction with SAS-5 suggest a regulatory mechanism inC. eleganscentriole assemblyQ27674490
A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutantsQ27731470
Expression of the SIL gene is correlated with growth induction and cellular proliferationQ28254853
Sil overexpression in lung cancer characterizes tumors with increased mitotic activityQ28258388
The SIL gene is required for mouse embryonic axial development and left-right specificationQ28509071
Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryoQ28509974
The primary cilium: a signalling centre during vertebrate developmentQ29547197
Patched1 regulates hedgehog signaling at the primary ciliumQ29547515
A molecular signature of metastasis in primary solid tumorsQ29614442
The vertebrate primary cilium in development, homeostasis, and diseaseQ29614609
The primary cilium as the cell's antenna: signaling at a sensory organelleQ29615165
Centrioles, centrosomes, and cilia in health and diseaseQ29615173
Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference setQ29616463
Drosophila Ana2 is a conserved centriole duplication factorQ33643718
Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesisQ33954530
Centrosomes as signalling centresQ33959927
Centrosome aberrations: cause or consequence of cancer progression?Q34157650
Absence of centrioles in the first and second meiotic spindles of mouse oocytesQ34227802
Re-evaluating centrosome functionQ34354353
Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole.Q34453657
The Stil protein regulates centrosome integrity and mitosis through suppression of ChfrQ34541480
Centrosome replication, genomic instability and cancerQ34622335
Structure and non-structure of centrosomal proteins.Q34720695
Transmembrane domains in the functions of Fc receptorsQ35088749
Scaffolds, levers, rods and springs: diverse cellular functions of long coiled-coil proteinsQ35865779
STIL binding to Polo-box 3 of PLK4 regulates centriole duplicationQ35933358
The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organizationQ35950169
From stem cell to embryo without centriolesQ35980950
The primary cilium in cell signaling and cancerQ36526550
Centrosome biogenesis and function: centrosomics brings new understandingQ36823707
Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephalyQ37156137
Binding of STIL to Plk4 activates kinase activity to promote centriole assemblyQ38860972
Cell-cycle-regulated expression of STIL controls centriole number in human cellsQ39393625
The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryoQ39750041
The SIL gene is essential for mitotic entry and survival of cancer cells.Q40141674
Lack of centrioles and primary cilia in STIL(-/-) mouse embryosQ41928965
Plk4-dependent phosphorylation of STIL is required for centriole duplication.Q42015542
The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in fliesQ42425294
The SAS-5 N-terminal domain is a tetramer, with implications for centriole assembly in C. elegansQ42770514
Amino acid contacts in proteins adapted to different temperatures: hydrophobic interactions and surface charges play a key roleQ43025403
Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2.Q47069578
SAS-4 is a C. elegans centriolar protein that controls centrosome sizeQ47172631
SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycleQ48255695
gamma-Tubulin is present in acentriolar MTOCs during early mouse developmentQ49145756
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)24296
P577publication date2016-04-14
P1433published inScientific ReportsQ2261792
P1476titleMolecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells
P478volume6