The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr

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The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/JCS.079731
P932PMC publication ID3031367
P698PubMed publication ID21245198
P5875ResearchGate publication ID49765179

P50authorPeter AplanQ89272233
P2093author name stringAhuvit David
Alwin Krämer
Asher Castiel
Shai Izraeli
Ilan R Kirsch
Michael Brandeis
Sharon Moshkovitz
Michal Mark Danieli
P2860cites workChfr defines a mitotic stress checkpoint that delays entry into metaphaseQ22254761
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinaseQ24301325
Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesionQ24301594
PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint proteinQ24306346
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomesQ24312101
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligaseQ24321736
Chfr is linked to tumour metastasis through the downregulation of HDAC1Q24324032
Active cyclin B1-Cdk1 first appears on centrosomes in prophaseQ24338617
Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpointQ24530007
A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain sizeQ24570115
Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemiaQ24594559
The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transitionQ24652690
Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cellsQ24676923
Mad2 overexpression promotes aneuploidy and tumorigenesis in miceQ24684680
Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFRQ28187458
Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activityQ28209840
Expression of the SIL gene is correlated with growth induction and cellular proliferationQ28254853
Sil overexpression in lung cancer characterizes tumors with increased mitotic activityQ28258388
The SIL gene is required for mouse embryonic axial development and left-right specificationQ28509071
Chfr is required for tumor suppression and Aurora A regulationQ28510913
Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findingsQ28769509
A molecular signature of metastasis in primary solid tumorsQ29614442
Coordinated requirements of human topo II and cohesin for metaphase centromere alignment under Mad2-dependent spindle checkpoint surveillanceQ30477159
The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domainQ33323380
A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila.Q33370199
Primary microcephaly: do all roads lead to Rome?Q33629131
Drosophila Ana2 is a conserved centriole duplication factorQ33643718
Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4.Q33960544
BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephalyQ34085175
SAK/PLK4 is required for centriole duplication and flagella developmentQ34472675
The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organizationQ35950169
Polo-like kinase 1 is essential for early embryonic development and tumor suppressionQ36949896
Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephalyQ37156137
Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1Q37267614
Nuclear localization of Chfr is crucial for its checkpoint functionQ39867562
The SIL gene is essential for mitotic entry and survival of cancer cells.Q40141674
Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activityQ40144143
A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association.Q40328385
The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal proteinQ40381206
Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesisQ40542776
The mitotic checkpoint gene, SIL is regulated by E2F1.Q42126696
Roles of polo-like kinase 1 in the assembly of functional mitotic spindlesQ45086018
The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleusQ45240522
Chfr interacts and colocalizes with TCTP to the mitotic spindle.Q52587117
P433issuePt 4
P407language of work or nameEnglishQ1860
P304page(s)532-539
P577publication date2011-01-18
P1433published inJournal of Cell ScienceQ1524177
P1476titleThe Stil protein regulates centrosome integrity and mitosis through suppression of Chfr
P478volume124

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cites work (P2860)
Q3696102214-3-3γ Prevents Centrosome Amplification and Neoplastic Progression
Q26858999A developmental and genetic classification for malformations of cortical development: update 2012
Q36262514A novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway
Q28551506Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of Tamoxifen in Breast Cancer Cells
Q36625721Building a centriole
Q37967195CHFR: a key checkpoint component implicated in a wide range of cancers
Q36848137Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly
Q36202759Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein dma1 in fission yeast
Q37158051Genetic causes of microcephaly and lessons for neuronal development
Q41915395Identifying protein-protein interaction sites using peptide arrays
Q41928965Lack of centrioles and primary cilia in STIL(-/-) mouse embryos
Q30559126Loss of centrioles causes chromosomal instability in vertebrate somatic cells
Q56770849Malformations of cortical development and epilepsy
Q30556376Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression.
Q40148678Molecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells
Q49918080Novel STIL Compound Heterozygous Mutations Cause Severe Fetal Microcephaly and Centriolar Lengthening
Q36564548Primary cilia and aberrant cell signaling in epithelial ovarian cancer
Q27674490SAS-6 coiled-coil structure and interaction with SAS-5 suggest a regulatory mechanism inC. eleganscentriole assembly
Q47851151STIL balancing primary microcephaly and cancer
Q64087935STIL: a multi-function protein required for dopaminergic neural proliferation, protection, and regeneration
Q33689051Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer
Q28071761The PLK4-STIL-SAS-6 module at the core of centriole duplication
Q53090758The STIL protein contains intrinsically disordered regions that mediate its protein-protein interactions.
Q38222110The centrosome duplication cycle in health and disease.
Q24294326The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation
Q37622621Transcription of the SCL/TAL1 interrupting Locus (Stil) is required for cell proliferation in adult Zebrafish Retinas

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