Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors

scientific article published on 3 April 2007

Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.MT.6300152
P698PubMed publication ID17406345
P5875ResearchGate publication ID6416301

P50authorTobias MaetzigQ114410920
Rainer LoewQ114563947
Axel SchambachQ42229187
Melanie GallaQ42231242
P2093author name stringChristopher Baum
P2860cites workDirect interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signalQ72718794
Murine leukemia induced by retroviral gene markingQ77975543
Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cellsQ81353679
Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymeraseQ24535920
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1Q28210584
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integrationQ28242708
Mechanism and regulation of mRNA polyadenylationQ29614774
A third-generation lentivirus vector with a conditional packaging systemQ29616120
Transcription start regions in the human genome are favored targets for MLV integrationQ29618456
RNA 3' readthrough of oncoretrovirus and lentivirus: implications for vector safety and efficacyQ34342598
Polyadenylation: a tail of two complexes.Q35033251
The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms.Q35207740
Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cellsQ35604467
Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathwaysQ35642820
Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicityQ35849232
Retroviral insertional mutagenesis: past, present and futureQ36318150
3' end processing of the prothrombin mRNA in thrombophiliaQ36426645
Definition of the upstream efficiency element of the simian virus 40 late polyadenylation signal by using in vitro analysesQ36706227
Efficiency of utilization of the simian virus 40 late polyadenylation site: effects of upstream sequencesQ36761958
The human immunodeficiency virus type 1 polyadenylylation signal: a 3' long terminal repeat element upstream of the AAUAAA necessary for efficient polyadenylylationQ37426718
The retroviruses human immunodeficiency virus type 1 and Moloney murine leukemia virus adopt radically different strategies to regulate promoter-proximal polyadenylation.Q39605433
Regulation of polyadenylation in hepatitis B viruses: stimulation by the upstream activating signal PS1 is orientation-dependent, distance-independent, and additiveQ40508994
Sequences regulating temporal poly(A) site switching in the adenovirus major late transcription unitQ40642300
Upstream sequence elements enhance poly(A) site efficiency of the C2 complement gene and are phylogenetically conservedQ40789024
Distinct domains of AU-rich elements exert different functions in mRNA destabilization and stabilization by p38 mitogen-activated protein kinase or HuR.Q40886532
Sequence elements upstream of the 3' cleavage site confer substrate strength to the adenovirus L1 and L3 polyadenylation sitesQ41882662
The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutationsQ44826905
A dissection of the cauliflower mosaic virus polyadenylation signalQ45110213
Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical researchQ45857905
Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B virusesQ46958551
Predictable and efficient retroviral gene transfer into murine bone marrow repopulating cells using a defined vector doseQ47334460
Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.Q54662841
Context Dependence of Different Modules for Posttranscriptional Enhancement of Gene Expression from Retroviral VectorsQ58195243
Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitroQ70988084
CPSF recognition of an HIV-1 mRNA 3'-processing enhancer: multiple sequence contacts involved in poly(A) site definitionQ72427107
P433issue6
P304page(s)1167-1173
P577publication date2007-04-03
P1433published inMolecular TherapyQ15762400
P1476titleImproving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors
P478volume15

Reverse relations

cites work (P2860)
Q246486503' end mRNA processing: molecular mechanisms and implications for health and disease
Q39782235A new PG13-based packaging cell line for stable production of clinical-grade self-inactivating gamma-retroviral vectors using targeted integration.
Q38317683A self-deletion lentiviral vector to reduce the risk of replication-competent virus formation
Q39856750Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery.
Q35198350Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery
Q38073294Biosafety features of lentiviral vectors
Q58698412CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms
Q36102927Clinical-scale lentiviral vector transduction of PBL for TCR gene therapy and potential for expression in less-differentiated cells
Q45861548Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK.
Q28066817Cross- and Co-Packaging of Retroviral RNAs and Their Consequences
Q39825383Cross-packaging of genetically distinct mouse and primate retroviral RNAs
Q27673743Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors
Q90440857Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders
Q37197942Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition
Q41948139Development of safer gene delivery systems to minimize the risk of insertional mutagenesis-related malignancies: a critical issue for the field of gene therapy
Q40609634Elements of lentiviral vector design toward gene therapy for treating mucopolysaccharidosis I.
Q37358032Enrichment of human hematopoietic stem/progenitor cells facilitates transduction for stem cell gene therapy
Q36644230Evading the immune response upon in vivo gene therapy with viral vectors.
Q35982211Evaluation of γ-retroviral vectors that mediate the inducible expression of IL-12 for clinical application
Q26859020Foamy virus vectors for HIV gene therapy
Q34223822Gammaretroviral vectors: biology, technology and application
Q39237421Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side
Q34556239Graded or threshold response of the tet-controlled gene expression: all depends on the concentration of the transactivator
Q21090483Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice
Q40208488Improved microRNA suppression by WPRE-linked tough decoy microRNA sponges.
Q34757266Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment
Q57174327In vivo imaging of the spatiotemporal activity of the eIF2 -ATF4 signaling pathway: Insights into stress and related disorders
Q37718180Inclusion of the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances AAV2-Driven Transduction of Mouse and Human Retina
Q34668961Influence of untranslated regions on retroviral mRNA transfer and expression
Q64236162Innovative Therapy for Alzheimer's Disease-With Focus on Biodelivery of NGF
Q33713156Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors
Q37506025Integration-deficient lentiviral vectors: a slow coming of age.
Q33713951Mechanism of reduction in titers from lentivirus vectors carrying large inserts in the 3'LTR.
Q39689270Neonatal gene therapy of glycogen storage disease type Ia using a feline immunodeficiency virus-based vector
Q34200828Novel lentiviral vectors with mutated reverse transcriptase for mRNA delivery of TALE nucleases
Q37684186Optimization of AAV expression cassettes to improve packaging capacity and transgene expression in neurons
Q33713427Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element
Q40003414Physiological promoters reduce the genotoxic risk of integrating gene vectors
Q26781432Progresses towards safe and efficient gene therapy vectors
Q37153580Recent advances in gene therapy for severe congenital immunodeficiency diseases
Q42692898Risk assessment in skin gene therapy: viral-cellular fusion transcripts generated by proviral transcriptional read-through in keratinocytes transduced with self-inactivating lentiviral vectors
Q34204409Scale-up and manufacturing of clinical-grade self-inactivating γ-retroviral vectors by transient transfection
Q38879455Single-step cloning-screening method: a new tool for developing and studying high-titer viral vector producer cells.
Q42070127The U3 region of Moloney murine leukemia virus contains position-independent cis-acting sequences involved in the nuclear export of full-length viral transcripts
Q37143395The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
Q37782290The use of cell-delivered gene therapy for the treatment of HIV/AIDS
Q37830029The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors
Q57493531Transient Retrovirus-Based CRISPR/Cas9 All-in-One Particles for Efficient, Targeted Gene Knockout
Q34127579Translating Sleeping Beauty transposition into cellular therapies: victories and challenges
Q36341562Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5' short ORFs
Q45863292Use of human MAR elements to improve retroviral vector production.
Q34082215Use of the piggyBac transposon to create stable packaging cell lines for the production of clinical-grade self-inactivating γ-retroviral vectors
Q39877036Validation of a mutated PRE sequence allowing high and sustained transgene expression while abrogating WHV-X protein synthesis: application to the gene therapy of WAS.
Q38800643Viral Vectors: The Road to Reducing Genotoxicity
Q38338190Viral expression cassette elements to enhance transgene target specificity and expression in gene therapy
Q37262766Viral vectors: from virology to transgene expression

Search more.