What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection?

scientific article published on 19 June 2017

What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1101/CSHPERSPECT.A028803
P932PMC publication ID5899041
P698PubMed publication ID28630076

P2093author name stringPatrick C Wilson
Christopher T Stamper
P2860cites workIntricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturationQ36403602
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice.Q36627503
Antibody diversification by somatic mutation: from Burnet onwardsQ37052624
Immunologic Basis for Long HCDR3s in Broadly Neutralizing Antibodies Against HIV-1.Q38219407
Antibody B cell responses in HIV-1 infectionQ38252874
Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody GenesQ38388195
Germinal center selection and the antibody response to influenzaQ38615063
Broadly Neutralizing Antibodies Against HIV: New Insights to Inform Vaccine Design.Q38632666
HIV-Host Interactions: Implications for Vaccine DesignQ26765966
Affinity enhancement of antibodies: how low-affinity antibodies produced early in immune responses are followed by high-affinity antibodies later and in memory B-cell responsesQ26998642
Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic AntibodyQ27644415
Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine designQ27644634
Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 NeutralizationQ27677117
Predominant autoantibody production by early human B cell precursorsQ29619656
Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis.Q30352862
Advances in the development of influenza virus vaccines.Q30372164
Immune history profoundly affects broadly protective B cell responses to influenza.Q30382131
Multi-epitope Models Explain How Pre-existing Antibodies Affect the Generation of Broadly Protective Responses to InfluenzaQ30389700
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infectionQ30398435
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporterQ30498133
Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germlineQ34075820
Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genesQ34270980
Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern ChinaQ34350881
Differences in potential for amino acid change after mutation reveals distinct strategies for kappa and lambda light-chain variationQ35127575
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogenQ35969973
P577publication date2017-06-19
P1433published inCold Spring Harbor Perspectives in BiologyQ3927509
P1476titleWhat Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection?

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cites work (P2860)
Q90478416Memory CD4+ T cells enhance B-cell responses to drifting influenza immunization
Q55003119Selection and Neutral Mutations Drive Pervasive Mutability Losses in Long-Lived Anti-HIV B-Cell Lineages.

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