Selection and Neutral Mutations Drive Pervasive Mutability Losses in Long-Lived Anti-HIV B-Cell Lineages.

scientific article published in May 2018

Selection and Neutral Mutations Drive Pervasive Mutability Losses in Long-Lived Anti-HIV B-Cell Lineages. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/MOLBEV/MSY024
P932PMC publication ID5913683
P698PubMed publication ID29688540

P50authorSarah CobeyQ56072288
P2093author name stringDaniel Zinder
Marcos C Vieira
P2860cites workBayesian phylogenetics with BEAUti and the BEAST 1.7Q24286945
Codon usage tabulated from international DNA sequence databases: status for the year 2000Q24498251
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virusQ27644501
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodiesQ27644515
MACSE: Multiple Alignment of Coding SEquences accounting for frameshifts and stop codonsQ28334425
Consistency of VDJ Rearrangement and Substitution Parameters Enables Accurate B Cell Receptor Sequence AnnotationQ28602773
Quantifying evolutionary constraints on B-cell affinity maturationQ28640162
Inferring processes underlying B-cell repertoire diversityQ28640380
Bayesian random local clocks, or one rate to rule them allQ28749030
Immune history profoundly affects broadly protective B cell responses to influenza.Q30382131
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infectionQ30398435
Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cellsQ30417080
Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing dataQ30706182
A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing DataQ31135078
Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered processQ33198930
Adaptation to different human populations by HIV-1 revealed by codon-based analysesQ33247450
Synonymous substitution rates predict HIV disease progression as a result of underlying replication dynamicsQ33274194
Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic HypermutationQ33654599
Impaired antibody affinity maturation process characterizes a subset of patients with common variable immunodeficiency.Q52023797
The genealogy of a sequence subject to purifying selection at multiple sites.Q52036045
Role of mutator alleles in adaptive evolution.Q54564129
Costs and Benefits of High Mutation Rates: Adaptive Evolution of Bacteria in the Mouse GutQ56944626
Somatic mutation and the maturation of immune response to 2-phenyl oxazoloneQ58019387
Mechanism of antigen-driven selection in germinal centresQ59072211
Codon bias targets mutation.Q59081204
Germinal centersQ34245271
B-cell-lineage immunogen design in vaccine development with HIV-1 as a case studyQ34273373
Quantifying selection in high-throughput Immunoglobulin sequencing data setsQ34284964
Immunoglobulin somatic hypermutationQ34638632
Coevolution with viruses drives the evolution of bacterial mutation rates.Q34722064
Differences in potential for amino acid change after mutation reveals distinct strategies for kappa and lambda light-chain variationQ35127575
Overlapping hotspots in CDRs are critical sites for V region diversificationQ35128767
B cell variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regionsQ35155724
Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 InfectionQ36020766
Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 InfectionQ36444787
Defect in IgV gene somatic hypermutation in common variable immuno-deficiency syndromeQ36639355
Lineage structure of the human antibody repertoire in response to influenza vaccinationQ36975946
Learning to count: robust estimates for labeled distances between molecular sequencesQ37324363
Effects of aging on B cell functionQ37553468
Antigen-driven selection of virgin and memory B cellsQ38595897
Genetic drift, selection and the evolution of the mutation rateQ38980350
Evolution of the human immunodeficiency virus envelope gene is dominated by purifying selection.Q40016358
Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodiesQ40118226
What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection?Q40153752
Genetic plasticity of V genes under somatic hypermutation: statistical analyses using a new resampling-based methodologyQ40414623
A Phylogenetic Codon Substitution Model for Antibody LineagesQ41996650
The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scalesQ42015134
Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesisQ43586184
Codon bias and plasticity in immunoglobulinsQ44868378
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P433issue5
P921main subjectneutral mutationQ3883802
P304page(s)1135-1146
P577publication date2018-05-01
P1433published inMolecular Biology and EvolutionQ1992656
P1476titleSelection and Neutral Mutations Drive Pervasive Mutability Losses in Long-Lived Anti-HIV B-Cell Lineages.
P478volume35

Reverse relations

cites work (P2860)
Q92827369Fierce Selection and Interference in B-Cell Repertoire Response to Chronic HIV-1
Q57178227The Bayesian optimist's guide to adaptive immune receptor repertoire analysis

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