Dual role for SUMO E2 conjugase Ubc9 in modulating the transforming and growth-promoting properties of the HMGA1b architectural transcription factor

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Dual role for SUMO E2 conjugase Ubc9 in modulating the transforming and growth-promoting properties of the HMGA1b architectural transcription factor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M610919200
P698PubMed publication ID17350957

P2093author name stringJie Lu
Edward V Prochownik
Youjun Li
P2860cites workA novel role for high-mobility group a proteins in cellular senescence and heterochromatin formationQ24299446
Ubc9 interacts with SOX4 and represses its transcriptional activityQ24319664
Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1Q24656539
SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complexQ24678180
Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.Q28117154
HMGI/Y proteins: flexible regulators of transcription and chromatin structureQ28201754
Differential interactions of Id proteins with basic-helix-loop-helix transcription factorsQ28245175
The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1Q28587609
Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-CQ28588994
SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targetingQ29619527
Ubc9 interacts with chicken ovalbumin upstream promoter-transcription factor I and represses receptor-dependent transcriptionQ30749768
In vivo posttranslational modifications of the high mobility group A1a proteins in breast cancer cells of differing metastatic potentialQ33206483
Dynamic and differential in vivo modifications of the isoform HMGA1a and HMGA1b chromatin proteinsQ33209784
Sumoylation induced by the Arf tumor suppressor: a p53-independent functionQ33821331
Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cellsQ33966952
The HMG I proteins: dynamic roles in gene activation, development, and tumorigenesisQ34085807
Molecular biology of HMGA proteins: hubs of nuclear functionQ34095287
PDSM, a motif for phosphorylation-dependent SUMO modificationQ34248164
The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia.Q34321598
Role of the high mobility group A proteins in human lipomasQ34384823
Intracellular targeting of proteins by sumoylationQ34430550
Competition between HMG-I(Y), HMG-1 and histone H1 on four-way junction DNA.Q34634739
The sentrin-conjugating enzyme mUbc9 interacts with GLUT4 and GLUT1 glucose transporters and regulates transporter levels in skeletal muscle cellsQ35007234
Ubc9 interacts with a nuclear localization signal and mediates nuclear localization of the paired-like homeobox protein Vsx-1 independent of SUMO-1 modificationQ35887800
Molecular mechanism of HMGA1 deregulation in human neuroblastoma.Q36143513
Targeting Ubc9 for cancer therapyQ36318546
Posttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into nuclear bodiesQ37291219
High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity.Q40341382
p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners.Q40426297
C-Myc-independent restoration of multiple phenotypes by two C-Myc target genes with overlapping functionsQ40444185
Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulationQ40525051
Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformationQ40570030
HMG-I/Y in human breast cancer cell linesQ40733016
A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomasQ42796064
Distinct Roles for MAX Protein Isoforms in Proliferation and ApoptosisQ42798685
Pag, a putative tumor suppressor, interacts with the Myc Box II domain of c-Myc and selectively alters its biological function and target gene expressionQ42811126
Identification of a substrate recognition site on Ubc9.Q43904668
High mobility group protein HMGI(Y) enhances tumor cell growth, invasion, and matrix metalloproteinase-2 expression in prostate cancer cellsQ47431419
Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway.Q50754258
Increased expression of high mobility group A proteins in lung cancer.Q53633597
Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas.Q54678305
P433issue18
P407language of work or nameEnglishQ1860
P304page(s)13363-13371
P577publication date2007-03-09
P1433published inJournal of Biological ChemistryQ867727
P1476titleDual role for SUMO E2 conjugase Ubc9 in modulating the transforming and growth-promoting properties of the HMGA1b architectural transcription factor
P478volume282

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cites work (P2860)
Q34939445A Novel Pathway that Links Caveolin-1 Down-Regulation to BRCA1 Dysfunction in Serous Epithelial Ovarian Cancer Cells
Q48222762Assessing predictions of fitness effects of missense mutations in SUMO-conjugating enzyme UBE2I.
Q94305238BRCA1 Mutation Leads to Deregulated Ubc9 Levels which Triggers Proliferation and Migration of Patient-Derived High Grade Serous Ovarian Cancer and Triple Negative Breast Cancer Cells
Q36206491BRCA1 proteins regulate growth of ovarian cancer cells by tethering Ubc9
Q35624739Core promoter-selective function of HMGA1 and Mediator in Initiator-dependent transcription
Q37471156Polymorphism of UBC9 gene encoding the SUMO-E2-conjugating enzyme and breast cancer risk.
Q39125376Proteomic profile of maternal-aged blastocoel fluid suggests a novel role for ubiquitin system in blastocyst quality.
Q37001370Roles of HMGA proteins in cancer
Q47414975Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion
Q35898032Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins

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