| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/SJ.BJP.0707189 |
| P8608 | Fatcat ID | release_dyy4bin6trc3va5arqaddijzmi |
| P932 | PMC publication ID | 2013909 |
| P698 | PubMed publication ID | 17339833 |
| P5875 | ResearchGate publication ID | 6466559 |
| P50 | author | Geert Martens | Q44970298 |
| P2093 | author name string | D Pipeleers | |
| H Heimberg | |||
| Y Cai | |||
| M Van de Casteele | |||
| S A Hinke | |||
| J Finsi | |||
| P2860 | cites work | Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade | Q21245891 |
| Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes | Q22241283 | ||
| Oral Antidiabetic Agents | Q22241436 | ||
| Role of AMP-activated protein kinase in mechanism of metformin action | Q22241898 | ||
| The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes | Q24290792 | ||
| A mechanism for the synergistic antimalarial action of atovaquone and proguanil | Q24550657 | ||
| Use of a soluble tetrazolium compound to assay metabolic activation of intact beta cells | Q47832844 | ||
| Kinetic studies of citrate synthase from rat kidney and rat brain | Q48612320 | ||
| Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. | Q51586347 | ||
| Kinetic microplate-based assays for inhibitors of mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:cytochrome c oxidoreductase. | Q52571530 | ||
| Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway. | Q54783174 | ||
| Effects of glibenclamide and metformin (alone or in combination) on insulin release from isolated human pancreatic islets | Q57504528 | ||
| The effect of biguanides on secretion and biosynthesis of insulin in isolated pancreatic islets of rats | Q69380502 | ||
| The effect of dimethylbiguanide on glucose tolerance, serum insulin and growth hormone in obese patients | Q70376325 | ||
| Quantitative subcellular imaging of glucose metabolism within intact pancreatic islets | Q71081856 | ||
| Treatment of the obese diabetic. A comparative study of placebo, sulfonylurea and phenformin | Q71202019 | ||
| Purification of rat pancreatic B-cells by fluorescence-activated cell sorting | Q73085243 | ||
| Respiratory inhibition and hypoglycemia by biguanides and decamethylenediguanidine | Q78464339 | ||
| Reduction by phenformin of excessive insulin levels after glucose loading in obese and diabetic subjects | Q79503472 | ||
| The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress | Q24633606 | ||
| Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression | Q24682898 | ||
| AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling | Q28216932 | ||
| Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis | Q28218978 | ||
| Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene | Q28250528 | ||
| Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5'-AMP-activated protein kinase | Q28571968 | ||
| Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain | Q29615210 | ||
| Metformin and reduced risk of cancer in diabetic patients | Q29616275 | ||
| AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism | Q29617261 | ||
| 5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle | Q33869428 | ||
| Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. | Q34311558 | ||
| Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. | Q34506457 | ||
| Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1). | Q34523729 | ||
| The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism | Q34525699 | ||
| Co-secretion of amylin and insulin from cultured islet β-cells: Modulation by nutrient secretagogues, islet hormones and hypoglycemic agents | Q34540967 | ||
| Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis | Q35168497 | ||
| Plasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal | Q35794504 | ||
| AMPK, the metabolic syndrome and cancer | Q36024356 | ||
| Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program | Q37360298 | ||
| Effects of guanidine derivatives on mitochondrial function. 3. The mechanism of phenethylbiguanide accumulation and its relationship to in vitro respiratory inhibition. | Q38362681 | ||
| Biochemical regulation of mammalian AMP-activated protein kinase activity by NAD and NADH. | Q40508095 | ||
| AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms | Q40517124 | ||
| Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion | Q40590712 | ||
| Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc. | Q40611203 | ||
| Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues | Q40636642 | ||
| AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase | Q40657762 | ||
| Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression | Q40670353 | ||
| Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells | Q40707175 | ||
| Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line | Q40780866 | ||
| Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport | Q40863218 | ||
| Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion | Q40866515 | ||
| AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. | Q40998382 | ||
| Metformin hydrochloride: an antihyperglycemic agent. | Q41441420 | ||
| Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay | Q41626528 | ||
| NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat | Q42450731 | ||
| Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells | Q42475718 | ||
| Prevention of pancreatic cancer induction in hamsters by metformin | Q43552285 | ||
| Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation | Q43833571 | ||
| A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway | Q44297061 | ||
| Titration of non-occluded baculovirus using a cell viability assay | Q44338255 | ||
| AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase | Q44355884 | ||
| Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death | Q44559324 | ||
| Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? | Q44816749 | ||
| Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis | Q44970252 | ||
| Short-term intermittent exposure to diazoxide improves functional performance of beta-cells in a high-glucose environment | Q45005738 | ||
| Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. | Q45142823 | ||
| Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo | Q46809254 | ||
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 8 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1031-1043 | |
| P577 | publication date | 2007-03-05 | |
| P1433 | published in | British Journal of Pharmacology | Q919631 |
| P1476 | title | Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer | |
| P478 | volume | 150 |
| Q92381511 | A Review on The Protective Effects of Metformin in Sepsis-Induced Organ Failure |
| Q34746178 | AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration |
| Q40343333 | Age-dependent effects in fathead minnows from the anti-diabetic drug metformin |
| Q52840013 | Analysis of the codon use frequency of AMPK family genes from different species. |
| Q28507313 | Anchored phosphatases modulate glucose homeostasis |
| Q37679901 | Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz |
| Q58806129 | Biguanides enhance antifungal activity against Candida glabrata |
| Q90704540 | Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production |
| Q37035849 | Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1. |
| Q91596768 | Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose |
| Q27013561 | Cellular and molecular mechanisms of metformin: an overview |
| Q34285099 | Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells |
| Q90470418 | Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status |
| Q35016954 | Fluctuating vs. continuous exposure to H₂O₂: the effects on mitochondrial membrane potential, intracellular calcium, and NF-κB in astroglia |
| Q90047443 | Hepatocyte Injury and Hepatic Stem Cell Niche in the Progression of Non-Alcoholic Steatohepatitis |
| Q33556580 | High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice |
| Q26773988 | Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity |
| Q51779292 | Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) β-cells using metformin-induced metabolic deceleration as a model. |
| Q38442728 | Metabolic control of signalling pathways and metabolic auto-regulation |
| Q24617747 | Metformin activates AMP kinase through inhibition of AMP deaminase |
| Q35534198 | Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status |
| Q38689022 | Metformin and pancreatic cancer: Is there a role? |
| Q92278973 | Metformin as an adjuvant in breast cancer treatment |
| Q35114963 | Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis |
| Q51725457 | Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition. |
| Q37354549 | Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors |
| Q36928172 | Metformin overdose causes platelet mitochondrial dysfunction in humans. |
| Q42017731 | Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs. |
| Q36928176 | Metformin overdose: time to move on |
| Q37642352 | Metformin plays a dual role in MIN6 pancreatic β cell function through AMPK-dependent autophagy |
| Q39304557 | Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells |
| Q43116111 | Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice |
| Q26999344 | Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium |
| Q89713143 | Mitochondrial respiratory chain complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug |
| Q26778766 | New mechanisms of metformin action: Focusing on mitochondria and the gut |
| Q33873484 | Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication |
| Q47108808 | Short-term succinic acid treatment mitigates cerebellar mitochondrial OXPHOS dysfunction, neurodegeneration and ataxia in a Purkinje-specific spinocerebellar ataxia type 1 (SCA1) mouse model. |
| Q58701314 | Succinate and the shortcut to the cure of metformin-induced lactic acidosis |
| Q36182575 | Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators |
Search more.