Metformin plays a dual role in MIN6 pancreatic β cell function through AMPK-dependent autophagy (scientific article published on 20 February 2014)

Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis

Q36410666

Metformin: old wine in new bottle--evolving technology and therapy in diabetes

Q36412609

Cell death in the cardiovascular system

Q36425263

A chemical method for fast and sensitive detection of DNA synthesis in vivo

Q36497275

Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability

Q36510295

The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation

Q37200468

p62 at the crossroads of autophagy, apoptosis, and cancer

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The double-edged effect of autophagy in pancreatic beta cells and diabetes

Q37799223

Preservation of β-cell function: the key to diabetes prevention

Q37893344

The cardioprotective effects of metformin

Q37928363

Metformin and cancer therapy.

Q37962127

Liraglutide prevents high glucose level induced insulinoma cells apoptosis by targeting autophagy.

Q39181266

Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.

Q39380440

Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin.

Q39571793

Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells

Q40110227

Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

Q40162927

Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion

Q40590712

AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase

Q40657762

Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia

Q42442810

Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

Q42442818

Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells

Q42490936

Effects of metformin on oxidative stress, adenine nucleotides balance, and glucose-induced insulin release impaired by chronic free fatty acids exposure in rat pancreatic islets.

Q44184962

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

Q44328968

Berberine acutely inhibits insulin secretion from beta-cells through 3',5'-cyclic adenosine 5'-monophosphate signaling pathway

Q46568252

Rapamycin causes upregulation of autophagy and impairs islets function both in vitro and in vivo.

Q50510804

Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression.

Q54468428

A SAGE Approach to Discovery of Genes Involved in Autophagic Cell Death

Q57662251

Interaction of glibenclamide and metformin at the level of translation in pancreatic cells

Q82488223

Metformin-induced pancreatitis: A possible adverse drug effect during acute renal failure

Q83214083

P4510

describes a project that uses

ImageJ

Q1659584

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

metformin

autophagy

cell function

page(s)

268-277

P577

publication date

2014-02-20

P1433

published in

International Journal of Biological Sciences

Q6051326

P1476

title

Metformin plays a dual role in MIN6 pancreatic β cell function through AMPK-dependent autophagy

P478

volume

Reverse relations

cites work (P2860)

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