Fibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling.

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Fibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling. is …
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scholarly articleQ13442814

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P356DOI10.3390/IJMS20102517
P932PMC publication ID6567208
P698PubMed publication ID31121855

P50authorPo Sing LeungQ43172575
P2093author name stringSam Tsz Wai Cheng
Stephen Yu Ting Li
P2860cites workFibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathwayQ24607012
The AMPK signalling pathway coordinates cell growth, autophagy and metabolismQ24616273
Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant StateQ24625976
Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in PancreasQ27324101
Autophagy in the Pathogenesis of DiseaseQ27860558
Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic isletsQ28483101
Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma CellsQ42798453
Liraglutide Improves the Survival of INS-1 Cells by Promoting MacroautophagyQ42812444
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese miceQ43224118
Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity.Q43287114
Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liverQ46818626
Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeysQ46844955
Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment.Q54359435
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Q28506431
Autophagy: process and functionQ29547296
mTOR regulation of autophagyQ29616301
Autophagy in cell death: an innocent convict?Q29617604
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energyQ29618101
Free fatty acids, insulin resistance, and type 2 diabetes mellitusQ33650385
Autophagy: cellular and molecular mechanismsQ34103624
Islet beta cell failure in type 2 diabetesQ34698810
Fibroblast growth factor 21 corrects obesity in miceQ34805555
Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in miceQ35274798
The emerging role of autophagy in the pathophysiology of diabetes mellitusQ35985421
FGF21 ameliorates nonalcoholic fatty liver disease by inducing autophagyQ36082328
The role of autophagy in β‐cell lipotoxicity and type 2 diabetesQ37205819
High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor γ signalingQ37251086
AMP-activated protein kinase control of fat metabolism in skeletal muscleQ37401928
AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.Q37401935
Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/Sirt1 signaling in miceQ37550329
Metformin plays a dual role in MIN6 pancreatic β cell function through AMPK-dependent autophagyQ37642352
Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategiesQ37650996
Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice.Q37678960
The double-edged effect of autophagy in pancreatic beta cells and diabetesQ37799223
Role of islet β cell autophagy in the pathogenesis of diabetesQ38253012
Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibodyQ38315161
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effectsQ38351110
Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes MellitusQ38794405
Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic miceQ38800859
FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathwayQ38943985
Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice.Q38970746
Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunctionQ39281003
Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.Q39639032
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivationQ39816832
Chronic palmitate exposure inhibits AMPKalpha and decreases glucose-stimulated insulin secretion from beta-cells: modulation by fenofibrate.Q39999797
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cellsQ40173463
Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.Q40239037
Autophagy and cell death: no longer at oddsQ41556141
Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance.Q41760918
AMPK and autophagy get connected.Q41874222
High-fat diet increases autophagic flux in pancreatic beta cells in vivo and ex vivo in miceQ41917444
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat dietQ42442818
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectautophagyQ288322
P577publication date2019-05-22
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleFibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling.
P478volume20