IRE1α promotes viral infection by conferring resistance to apoptosis.

scientific article published on 6 June 2017

IRE1α promotes viral infection by conferring resistance to apoptosis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCISIGNAL.AAI7814
P932PMC publication ID5535312
P698PubMed publication ID28588082

P50authorAkiko IwasakiQ19958193
Susan L FinkQ55085991
Takao IwawakiQ80174205
Ryan D MolonyQ88251142
Brett LindenbachQ89673517
P2093author name stringCharles S Landis
Teshika R Jayewickreme
P2860cites workCoupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
miR-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer via targeting BCL2, BCL2L12 and MCL1.Q53376880
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
The unfolded protein response: integrating stress signals through the stress sensor IRE1αQ24293771
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsQ24298956
XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activationQ24304996
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small moleculeQ24596804
MicroRNAs: target recognition and regulatory functionsQ24609584
Divergent effects of PERK and IRE1 signaling on cell viabilityQ27438124
Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein responseQ27487012
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Proteasome inhibitors disrupt the unfolded protein response in myeloma cellsQ28155919
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell HomeostasisQ28389316
Targeting mitochondrial cell death pathway to overcome drug resistance with a newly developed iron chelateQ28474590
The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in miceQ28511677
Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteinsQ28546101
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKRQ28588429
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
An essential role in liver development for transcription factor XBP-1Q28593777
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
The mammalian unfolded protein responseQ29547400
An inhibitor of Bcl-2 family proteins induces regression of solid tumoursQ29547595
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cellsQ33320542
Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsidQ33784001
Upregulation of proapoptotic microRNA mir-125a after massive small bowel resection in ratsQ33974830
The SKIV2L RNA exosome limits activation of the RIG-I-like receptorsQ34071054
Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific.Q34107519
Viruses and apoptosisQ34308884
Interferon-stimulated genes: a complex web of host defensesQ34405609
The endoplasmic reticulum stress sensor IRE1α protects cells from apoptosis induced by the coronavirus infectious bronchitis virusQ34593885
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.Q34745565
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.Q35041384
ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells.Q35168302
IRE1α activation protects mice against acetaminophen-induced hepatotoxicityQ35760821
Influenza A viral replication is blocked by inhibition of the inositol-requiring enzyme 1 (IRE1) stress pathway.Q35762999
MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein responseQ35841763
Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN productionQ35903465
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.Q36393034
Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.Q36870862
Innate recognition of virusesQ36950601
The mitochondrial antiviral signaling protein, MAVS, is cleaved during apoptosisQ37009664
Inflammasome recognition of influenza virus is essential for adaptive immune responsesQ37061831
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.Q37091581
Two interferon-independent double-stranded RNA-induced host defense strategies suppress the common cold virus at warm temperatureQ37142759
RETRACTED: The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signalingQ37154230
IRE1: ER stress sensor and cell fate executorQ37282044
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viabilityQ37377347
Gliotoxin isolated from marine fungus Aspergillus sp. induces apoptosis of human cervical cancer and chondrosarcoma cellsQ37566168
Pattern recognition receptors and the innate immune response to viral infectionQ37945230
Virus-induced ER stress and the unfolded protein responseQ38072035
Endoplasmic reticulum stress signaling: the microRNA connectionQ38091632
Targeting the unfolded protein response in disease.Q38132652
Physiological roles of regulated Ire1 dependent decayQ38209331
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation.Q38320987
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.Q39299575
Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1.Q39620175
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.Q39814866
Hepatitis C virus non-structural protein NS4B can modulate an unfolded protein response.Q40330336
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.Q40519913
Caspase-3-like proteases are activated by infection but are not required for replication of vesicular stomatitis virusQ40775270
ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.Q41948428
The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assemblyQ42170036
Herpes simplex virus-1 disarms the unfolded protein response in the early stages of infection.Q42184608
Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosisQ42207479
Maintenance of endoplasmic reticulum (ER) homeostasis in herpes simplex virus type 1-infected cells through the association of a viral glycoprotein with PERK, a cellular ER stress sensor.Q42634140
Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesisQ42990870
Inhibition of cytochrome c release in Fas-mediated signaling pathway in transgenic mice induced to express hepatitis C viral proteinsQ43030664
Requirement of caspase-3 for efficient apoptosis induction and caspase-7 activation but not viral replication or cell rounding in cells infected with vesicular stomatitis virusQ45729660
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspasesQ46404646
Inhibition of microRNA-125a promotes human endothelial cell proliferation and viability through an antiapoptotic mechanism.Q50320388
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.Q52531761
P433issue482
P577publication date2017-06-06
P1433published inScience SignalingQ7433604
P1476titleIRE1α promotes viral infection by conferring resistance to apoptosis
P478volume10

Reverse relations

cites work (P2860)
Q59356198A virus-acquired host cytokine controls systemic aging by antagonizing apoptosis
Q92187408Activation of the Unfolded Protein Response Pathway in Cytotoxic T Cells: A Comparison Between in vitro Stimulation, Infection, and the Tumor Microenvironment
Q47614555Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses.
Q92611337Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP
Q61451175IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8 T Cell Priming
Q55283549IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases.
Q90073188IRE1α Promotes Zika Virus Infection via XBP1
Q59357517Induction of the unfolded protein response (UPR) during Marek's disease virus (MDV) infection
Q91447888Induction of the unfolded protein response (UPR) during pseudorabies virus infection
Q58711258Insights into the pathogenesis of herpes simplex encephalitis from mouse models
Q57098620The Coronavirus Transmissible Gastroenteritis Virus Evades the Type I Interferon Response through IRE1α-Mediated Manipulation of the MicroRNA miR-30a-5p/SOCS1/3 Axis.
Q57469940The Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein Response
Q91809029Understanding the Role of the Unfolded Protein Response Sensor IRE1 in the Biology of Antigen Presenting Cells

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