The Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein Response

scientific article published on 26 September 2018

The Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein Response is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.00896-18
P932PMC publication ID6158444
P698PubMed publication ID30045994

P50authorMohammed Nure Alam SiddiqueyQ85289662
Hongbo ZhangQ90474549
Jeremy P. KamilQ55755049
Anthony J DommaQ58663710
Christopher C NguyenQ58663720
P2093author name stringHongbo Zhang
Mohammed N A Siddiquey
P2860cites workTwo distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein responseQ74359929
Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factorsQ22008465
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
Plasma cell differentiation requires the transcription factor XBP-1Q24291453
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress responseQ24303865
Structural organization of the endoplasmic reticulumQ24538821
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Human Cytomegalovirus Strategies to Maintain and Promote mRNA TranslationQ26752742
Human cytomegalovirus infection activates and regulates the unfolded protein responseQ27469611
The unfolded protein response signals through high-order assembly of Ire1Q27653139
Site-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.Q27930296
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein responseQ27933479
Functional profiling of a human cytomegalovirus genomeQ28185252
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Decoding human cytomegalovirusQ28279933
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleusQ29620179
The endoplasmic reticulum provides the membrane platform for biogenesis of the flavivirus replication complexQ30484619
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clusteringQ30496639
Functional genetic analysis of rhesus cytomegalovirus: Rh01 is an epithelial cell tropism factorQ33311454
Feline calicivirus p32, p39 and p30 proteins localize to the endoplasmic reticulum to initiate replication complex formationQ33913603
Gangliosides are receptors for murine polyoma virus and SV40Q34225546
eIF2 and the control of cell physiologyQ34554304
The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivoQ34621429
PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infectionQ34671888
The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membraneQ34673029
Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translationQ34719370
Cytomegalovirus downregulates IRE1 to repress the unfolded protein responseQ34945470
Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane proteinQ34977917
The human cytomegalovirus protein pUL38 suppresses endoplasmic reticulum stress-mediated cell death independently of its ability to induce mTORC1 activationQ35192837
A viral regulator of glycoprotein complexes contributes to human cytomegalovirus cell tropism.Q35378089
Human cytomegalovirus UL38 protein blocks apoptosisQ35785145
Cellular or viral protein binding to a cytomegalovirus promoter transcription initiation site: effects on transcriptionQ35861289
Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded-protein responseQ36086646
Natural Killer Cell Evasion Is Essential for Infection by Rhesus CytomegalovirusQ36118554
Endocytosis of simian virus 40 into the endoplasmic reticulumQ36222240
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
The ULb' region of the human cytomegalovirus genome confers an increased requirement for the viral protein kinase UL97.Q36827232
Endoplasmic reticulum stress in disease pathogenesisQ36842308
Reevaluation of human cytomegalovirus coding potential.Q37089601
The mammalian endoplasmic reticulum-associated degradation systemQ37122324
Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environmentsQ37124391
Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell deathQ37145200
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complexQ37380692
The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complexQ39727479
Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains.Q39872953
IRE1α promotes viral infection by conferring resistance to apoptosis.Q40170347
Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex productsQ40458981
Human Cytomegalovirus Induces the Endoplasmic Reticulum Chaperone BiP through Increased Transcription and Activation of Translation by Using the BiP Internal Ribosome Entry SiteQ41894476
Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi.Q44298432
Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E.Q45397798
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.Q46900500
The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genomeQ48264323
Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides.Q49914066
Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses.Q52716982
Chemical synthesis of the mouse mitochondrial genome.Q54407443
Human Cytomegalovirus Tropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That Governs Endoplasmic Reticulum-Associated Degradation of the Viral Envelope Glycoprotein gOQ59357147
A time-dependent phase shift in the mammalian unfolded protein responseQ72997174
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectCytomegalovirusQ6946
endoplasmic reticulumQ79927
immunologyQ101929
virologyQ7215
P577publication date2018-09-26
P1433published inJournal of VirologyQ1251128
P1476titleThe Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein Response
P478volume92

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cites work (P2860)
Q95661029Enhancement of guinea pig cytomegalovirus infection by two endogenously expressed components of the pentameric glycoprotein complex in epithelial cells
Q92255602Herpesviruses and the Unfolded Protein Response
Q59357147Human Cytomegalovirus Tropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That Governs Endoplasmic Reticulum-Associated Degradation of the Viral Envelope Glycoprotein gO
Q92482098Human Cytomegalovirus pUL37x1 Is Important for Remodeling of Host Lipid Metabolism
Q91605042KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication
Q60960757Pathogen at the Gates: Human Cytomegalovirus Entry and Cell Tropism
Q93062545Subversion of Immune Response by Human Cytomegalovirus
Q91853562The Human Cytomegalovirus Nonstructural Glycoprotein UL148 Reorganizes the Endoplasmic Reticulum
Q92000954The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc
Q91985221The integrated stress response promotes B7H6 expression

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