Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity.

scientific article published on 26 December 2006

Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M608857200
P698PubMed publication ID17190831

P50authorMinetta C LiuQ89668739
Robert ClarkeQ47156400
P2093author name stringRichard D Minshall
Aifen Wang
Ayesha N Shajahan
Markus Decker
P2860cites workPhosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.Q47828300
Constitutive and Growth Factor-Regulated Phosphorylation of Caveolin-1 Occurs at the Same Site (Tyr-14) in Vivo: Identification of a c-Src/Cav-1/Grb7 Signaling CassetteQ56591619
Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cellsQ57369938
Caveolin-1 inhibits breast cancer growth and metastasisQ57369965
Taxane-containing chemotherapy in the treatment of early breast cancer patientsQ58466091
Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cellsQ24317614
Taxol suppresses dynamics of individual microtubules in living human tumor cellsQ24657911
The transcriptional targets of p53 in apoptosis controlQ28248026
Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinasesQ28296324
Oestrogen-mediated tyrosine phosphorylation of caveolin-1 and its effect on the oestrogen receptor localisation: an in vivo studyQ28577513
Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell deathQ33539855
Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.Q33944029
Cell biology of caveolae and caveolinQ34365115
A systematic review of taxane-containing regimens for metastatic breast cancerQ36211570
Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeletonQ36220765
Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent stepsQ36236367
Taxol stabilizes microtubules in mouse fibroblast cellsQ36360499
Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosisQ36451137
Src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of Bcl-2.Q38282056
The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2.Q39677796
Taxol: an antimitotic agent with a new mechanism of actionQ40095632
Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cellsQ40342811
Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling.Q40481718
G2/M blockade by paclitaxel induces caveolin-1 expression in A549 lung cancer cells: caveolin-1 as a marker of cytotoxicityQ40498448
Up-regulation of caveolin expression by cytotoxic agents in drug-sensitive cancer cellsQ40657931
Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activationQ40698684
Involvement of p21 in mitotic exit after paclitaxel treatment in MCF-7 breast adenocarcinoma cell lineQ41073290
Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance.Q41523907
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membraneQ41715384
Gbetagamma activation of Src induces caveolae-mediated endocytosis in endothelial cellsQ42467002
Dual control of caveolar membrane traffic by microtubules and the actin cytoskeletonQ44177187
Cellular apoptosis is associated with increased caveolin-1 expression in macrophagesQ44460196
Src-mediated tyrosine phosphorylation of caveolin-1 induces its association with membrane type 1 matrix metalloproteinaseQ45091842
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)5934-5943
P577publication date2006-12-26
P1433published inJournal of Biological ChemistryQ867727
P1476titleCaveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity
P478volume282