| scholarly article | Q13442814 |
| P50 | author | David W. Russell | Q37382061 |
| David Mangelsdorf | Q28873610 | ||
| P2093 | author name string | Wenling Chen | |
| Daphne L Head | |||
| Guoxen Chen | |||
| P2860 | cites work | Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. | Q37388544 |
| Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux | Q40498524 | ||
| Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor | Q40528839 | ||
| Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation | Q40631077 | ||
| Cholesterol and hydroxycholesterol sulfotransferases: identification, distinction from dehydroepiandrosterone sulfotransferase, and differential tissue expression | Q40797774 | ||
| Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations | Q43567176 | ||
| Identification of gene-selective modulators of the bile acid receptor FXR. | Q44259003 | ||
| Conservation of the hydroxysteroid sulfotransferase SULT2B1 gene structure in the mouse: pre- and postnatal expression, kinetic analysis of isoforms, and comparison with prototypical SULT2A1. | Q44363908 | ||
| LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes | Q44531983 | ||
| Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator | Q44897939 | ||
| Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing | Q46533975 | ||
| Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene | Q48010812 | ||
| Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. | Q51805706 | ||
| Role of LXRs in control of lipogenesis | Q24290548 | ||
| Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway | Q24316367 | ||
| LXR, a nuclear receptor that defines a distinct retinoid response pathway | Q24317347 | ||
| Do oxysterols control cholesterol homeostasis? | Q24553299 | ||
| Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta | Q24553340 | ||
| Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors | Q24562732 | ||
| Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta | Q24598068 | ||
| A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily | Q24609094 | ||
| The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism | Q24657371 | ||
| Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha | Q24683359 | ||
| A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR | Q27641086 | ||
| Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover | Q28190054 | ||
| The enzymes, regulation, and genetics of bile acid synthesis | Q28204726 | ||
| Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha | Q28273937 | ||
| An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha | Q28294042 | ||
| Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice | Q28507493 | ||
| De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase | Q28591006 | ||
| Nuclear receptors and lipid physiology: opening the X-files | Q29619362 | ||
| Disruption of the oxysterol 7alpha-hydroxylase gene in mice. | Q33896722 | ||
| Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands | Q34083979 | ||
| Cholic acid mediates negative feedback regulation of bile acid synthesis in mice | Q34785939 | ||
| Sulfonation and molecular action | Q34953536 | ||
| Liver X Receptor Signaling Pathways in Cardiovascular Disease | Q35104848 | ||
| Hydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action. | Q35178386 | ||
| PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis | Q35920729 | ||
| P433 | issue | 1 | |
| P304 | page(s) | 73-79 | |
| P577 | publication date | 2007-01-01 | |
| P1433 | published in | Cell Metabolism | Q1254684 |
| P1476 | title | Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice | |
| P478 | volume | 5 |
| Q57174719 | ,-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity |
| Q37402754 | 24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation |
| Q39205339 | 25-Hydroxycholesterol regulates cholesterol homeostasis in the murine CATH.a neuronal cell line |
| Q35900607 | 25-Hydroxycholesterol-3-sulfate attenuates inflammatory response via PPARγ signaling in human THP-1 macrophages |
| Q37016677 | 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway. |
| Q36642388 | 5-cholesten-3β,25-diol 3-sulfate decreases lipid accumulation in diet-induced nonalcoholic fatty liver disease mouse model |
| Q34059001 | A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia. |
| Q40128752 | A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptor |
| Q91835445 | A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice |
| Q36307272 | A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol. |
| Q33915348 | A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol) |
| Q37244567 | Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice. |
| Q57476231 | Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol |
| Q46299102 | Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest |
| Q37413529 | Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease |
| Q37848059 | Adventures in Rhodococcus - from steroids to explosives. |
| Q37078892 | Antioxidant Supplements Improve Profiles of Hepatic Oxysterols and Plasma Lipids in Butter-fed Hamsters |
| Q37308791 | Are side-chain oxidized oxysterols regulators also in vivo? |
| Q26800190 | Armand-Frappier Outstanding Student Award--The emerging role of 25-hydroxycholesterol in innate immunity |
| Q43865615 | Association of liver X receptors (LXRs) genetic variants to gallbladder cancer susceptibility |
| Q37297846 | Bile acids as regulatory molecules |
| Q44932513 | Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes |
| Q52720528 | Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. |
| Q39180626 | Cellular Cholesterol Homeostasis in Alzheimer's Disease |
| Q42128898 | ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver |
| Q40116058 | Cholesterol 25-Hydroxylase Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication through Enzyme Activity-Dependent and -Independent Mechanisms |
| Q34378778 | Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons |
| Q39656931 | Cholesterol Sulfonation Enzyme, SULT2B1b, Modulates AR and Cell Growth Properties in Prostate Cancer |
| Q64114610 | Cholesterol Sulfotransferase SULT2B1b Modulates Sensitivity to Death Receptor Ligand TNFα in Castration-Resistant Prostate Cancer |
| Q102075589 | Cholesterol access in cellular membranes controls Hedgehog signaling |
| Q36295627 | Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice |
| Q38662757 | Cholesterol metabolites and tumor microenvironment: the road towards clinical translation. |
| Q37546947 | Cholesterol sulfate and cholesterol sulfotransferase inhibit gluconeogenesis by targeting hepatocyte nuclear factor 4α. |
| Q79701048 | Cholesterol-metabolizing cytochromes P450: implications for cholesterol lowering |
| Q48221935 | Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease. |
| Q24312811 | Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain |
| Q36175918 | Cytosolic sulfotransferase 2B1b promotes hepatocyte proliferation gene expression in vivo and in vitro. |
| Q36063700 | Deciphering the roles of the constitutive androstane receptor in energy metabolism |
| Q36906770 | Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties |
| Q33795949 | Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. |
| Q43203668 | Down-regulation of the LXR transcriptome provides the requisite cholesterol levels to proliferating hepatocytes |
| Q43153432 | Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis |
| Q40056973 | Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis |
| Q26996783 | Energy metabolism in the liver |
| Q58577758 | Engineered Animal Models Designed for Investigating Ethanol Metabolism, Toxicity and Cancer |
| Q28235379 | Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo |
| Q40759599 | Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis. |
| Q36303731 | Expanding roles for SREBP in metabolism |
| Q52649427 | Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). |
| Q37764891 | Functional implications of sterol transport by the oxysterol-binding protein gene family. |
| Q34020016 | Gene activation regresses atherosclerosis, promotes health, and enhances longevity |
| Q64059617 | Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells |
| Q37446740 | Glucose and Insulin Stimulate Lipogenesis in Porcine Adipocytes: Dissimilar and Identical Regulation Pathway for Key Transcription Factors |
| Q38904547 | Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice |
| Q34506779 | Hepatic accumulation of intestinal cholesterol is decreased and fecal cholesterol excretion is increased in mice fed a high-fat diet supplemented with milk phospholipids. |
| Q51763141 | High-dose supplemental selenite to male Syrian hamsters fed hypercholesterolaemic diets alters Ldlr, Abcg8 and Npc1l1 mRNA expression and lowers plasma cholesterol concentrations. |
| Q48171842 | IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis |
| Q33636952 | Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation |
| Q46391500 | Immunology: Oxysterols hold T cells in check |
| Q39879951 | Induction of SREBP-1c mRNA by differentiation and LXR ligand in human keratinocytes |
| Q42201187 | Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon |
| Q45363837 | Influenza A virus infection activates cholesterol sulfotransferase (SULT2B1b) in the lung of female C57BL/6 mice |
| Q36466124 | Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation. |
| Q33743822 | Interferon regulatory factor 1 restricts gammaherpesvirus replication in primary immune cells |
| Q37273150 | KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting. |
| Q24656186 | LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor |
| Q37061238 | LXR signaling couples sterol metabolism to proliferation in the acquired immune response. |
| Q54945090 | LXRɑ participates in the mTOR/S6K1/SREBP-1c signaling pathway during sodium palmitate-induced lipogenesis in HepG2 cells. |
| Q37457235 | LXRα fuels fatty acid-stimulated oxygen consumption in white adipocytes |
| Q36244293 | Ligands of Therapeutic Utility for the Liver X Receptors |
| Q34740192 | Listeria monocytogenes infection induces prosurvival metabolic signaling in macrophages |
| Q30426995 | Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice |
| Q37597310 | Liver X Receptor: Crosstalk Node for the Signaling of Lipid Metabolism, Carbohydrate Metabolism, and Innate Immunity |
| Q30252316 | Liver X Receptors Link Lipid Metabolism and Inflammation |
| Q90721357 | Liver X Receptors Regulate Cholesterol Metabolism and Immunity in Hepatic Nonparenchymal Cells |
| Q37723237 | Liver X receptor (LXR) and the reproductive system--a potential novel target for therapeutic intervention. |
| Q36747243 | Liver X receptor agonist modulation of cholesterol efflux in mice with intestine-specific deletion of microsomal triglyceride transfer protein |
| Q36704213 | Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells |
| Q38534041 | Liver X receptors and cholesterol metabolism: role in ventral midbrain development and neurodegeneration |
| Q38472467 | Liver X receptors and immune regulation |
| Q41621402 | Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer. |
| Q38924052 | Liver X receptors: from cholesterol regulation to neuroprotection-a new barrier against neurodegeneration in amyotrophic lateral sclerosis? |
| Q60045905 | Lucky, times ten: A career in Texas science |
| Q30371540 | Macrophage-independent regulation of reverse cholesterol transport by liver X receptors. |
| Q39841750 | Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide |
| Q33563327 | Mechanisms for increased expression of cholesterol 7alpha-hydroxylase (Cyp7a1) in lactating rats |
| Q98726639 | MicroRNA sequences modulating inflammation and lipid accumulation in macrophage "foam" cells: Implications for atherosclerosis |
| Q43849671 | Mitochondrial (dys)function and regulation of macrophage cholesterol efflux |
| Q26825337 | Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses |
| Q38892782 | Modulation of Macrophage Gene Expression via Liver X Receptor α Serine 198 Phosphorylation. |
| Q24336344 | Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands |
| Q24644318 | Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids |
| Q24655769 | Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking |
| Q30430126 | Nuclear receptors as drug targets for metabolic disease |
| Q28079661 | Nutrition, insulin resistance and dysfunctional adipose tissue determine the different components of metabolic syndrome |
| Q26770270 | O-GlcNAcylation and the Metabolic Shift in High-Proliferating Cells: All the Evidence Suggests that Sugars Dictate the Flux of Lipid Biogenesis in Tumor Processes |
| Q46616512 | OSBP negatively regulates ABCA1 protein stability |
| Q28256750 | OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages |
| Q35928736 | Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease. |
| Q38133807 | Oxysterols and redox signaling in the pathogenesis of non-alcoholic fatty liver disease. |
| Q33649595 | Oxysterols and their cellular effectors |
| Q40530687 | Oxysterols are allosteric activators of the oncoprotein Smoothened |
| Q40161538 | Oxysterols are substrates for cholesterol sulfotransferase |
| Q37799247 | Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networks |
| Q36754829 | Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1 |
| Q36244059 | Proliferation of human mammary cancer cells exposed to 27-hydroxycholesterol |
| Q24631052 | Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses |
| Q92527693 | Regulation of Brain Cholesterol: What Role Do Liver X Receptors Play in Neurodegenerative Diseases? |
| Q47643617 | Regulation of Cholesterol Sulfotransferase SULT2B1b by HNF4α Constitutes a Negative Feedback Control of Hepatic Gluconeogenesis |
| Q39954571 | Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha. |
| Q42940969 | Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate |
| Q93193771 | Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1-Mediated Cholesterol Removal |
| Q34299750 | Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol. |
| Q38074996 | Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the endobiotic function of a xenobiotic receptor |
| Q64966841 | SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy. |
| Q37966406 | SREBPs: metabolic integrators in physiology and metabolism |
| Q38135858 | SULT2B1: unique properties and characteristics of a hydroxysteroid sulfotransferase family |
| Q36850145 | SULT2B1b sulfotransferase: induction by vitamin D receptor and reduced expression in prostate cancer |
| Q28254889 | Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists |
| Q38130108 | Sterols and oxysterols in immune cell function |
| Q27664866 | Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN |
| Q24301662 | Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma |
| Q37308118 | Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes |
| Q34542885 | Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells |
| Q37575402 | Sulfation of 25-hydroxycholesterol regulates lipid metabolism, inflammatory responses, and cell proliferation |
| Q41198784 | Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration. |
| Q64289821 | Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist? |
| Q56507986 | The Cholesterol Derivative 27-Hydroxycholesterol Reduces Steatohepatitis in Mice |
| Q33924208 | The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. |
| Q58798256 | The PI3K/AKT pathway in obesity and type 2 diabetes |
| Q36832832 | The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation |
| Q39442545 | The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease. |
| Q90620365 | The expanded role of fatty acid metabolism in cancer: new aspects and targets |
| Q37386081 | The role of the lipogenic pathway in the development of hepatic steatosis. |
| Q46025705 | The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro. |
| Q33676201 | Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi |
| Q43540910 | Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1). |
| Q33672543 | Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP. |
| Q26778594 | Transcriptional regulation of hepatic lipogenesis |
| Q57128738 | Transgenic Overexpression of Steroid Sulfatase Alleviates Cholestasis |
| Q39758426 | Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses |
| Q38780188 | Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury |
| Q40374152 | Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1 |
| Q43132418 | Variation in OSBPL10 is associated with dyslipidemia |
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