Molecular determinants for G protein betagamma modulation of ionotropic glycine receptors.

scientific article published on 12 October 2006

Molecular determinants for G protein betagamma modulation of ionotropic glycine receptors. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M608272200
P698PubMed publication ID17040914
P5875ResearchGate publication ID6754485

P50authorLeonardo GuzmánQ73162363
P2093author name stringGünther Schmalzing
Juan Olate
Gustavo Moraga-Cid
Laerte Oliveira
Luis G Aguayo
Gonzalo E Yevenes
Svenja Haeger
P2860cites workElectrostatics of nanosystems: application to microtubules and the ribosomeQ24555224
Structure and gating mechanism of the acetylcholine receptor poreQ27641514
WHAT IF: a molecular modeling and drug design programQ27860734
PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculationsQ27861014
Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteinsQ28210562
Direct binding of G-protein betagamma complex to voltage-dependent calcium channelsQ28302204
Recent advances in Cys-loop receptor structure and functionQ28303306
Refined structure of the nicotinic acetylcholine receptor at 4A resolutionQ28306592
The many faces of G protein signalingQ28608944
Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structuresQ29619985
Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor.Q30336137
New methods to evaluate colocalization of fluorophores in immunocytochemical preparations as exemplified by a study on A2A and D2 receptors in Chinese hamster ovary cellsQ33220701
Ethanol actions on multiple ion channels: which are important?Q33767770
Coupling of agonist binding to channel gating in the GABA(A) receptorQ34170761
A cytoplasmic region determines single-channel conductance in 5-HT3 receptorsQ34214965
The glycinergic inhibitory synapse.Q34298993
Structure and function of the glycine receptor and related nicotinicoid receptorsQ34306215
Voltage-dependent modulation of N-type calcium channels by G-protein beta gamma subunitsQ34380635
G protein beta gamma subunits.Q34424307
Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?Q34987540
G protein modulation of voltage-gated calcium channelsQ35600890
Zn2+ ions: modulators of excitatory and inhibitory synaptic activity.Q35883459
Characterization of newly cloned variant of rat glycine receptor alpha1 subunit.Q40475507
GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitizationQ40558217
Molecular basis for interactions of G protein betagamma subunits with effectorsQ41032681
Regulation of excitatory and inhibitory neurotransmitter-gated ion channels by protein phosphorylationQ41541359
Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activationQ42065529
A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor alpha1 subunitQ44336498
Modulation of glycine-activated ion channel function by G-protein betagamma subunitsQ44511385
Developmental-dependent action of microtubule depolymerization on the function and structure of synaptic glycine receptor clusters in spinal neuronsQ44580819
Selective modulation of neuronal nicotinic acetylcholine receptor channel subunits by Go-protein subunits.Q46425946
Inhibitory synaptic transmission governs inspiratory motoneuron synchronizationQ46971017
Identification of three cAMP-dependent protein kinase (PKA) phosphorylation sites within the major intracellular domain of neuronal nicotinic receptor alpha4 subunitsQ48855798
Modulation of glycine receptor chloride channels by cAMP-dependent protein kinase in spinal trigeminal neuronsQ48859059
A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic MoleculesQ55918670
P433issue51
P407language of work or nameEnglishQ1860
P304page(s)39300-39307
P577publication date2006-10-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleMolecular determinants for G protein betagamma modulation of ionotropic glycine receptors
P478volume281

Reverse relations

cites work (P2860)
Q41627685A G protein-coupled α7 nicotinic receptor regulates signaling and TNF-α release in microglia
Q35182142A Single phenylalanine residue in the main intracellular loop of α1 γ-aminobutyric acid type A and glycine receptors influences their sensitivity to propofol
Q37014363A selective G betagamma-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol
Q35429674Activated G protein α s subunits increase the ethanol sensitivity of human glycine receptors
Q35177006Allosteric modulation of retinal GABA receptors by ascorbic acid
Q28585376Altered sedative effects of ethanol in mice with α1 glycine receptor subunits that are insensitive to Gβγ modulation
Q37444444Blockade of ethanol-induced potentiation of glycine receptors by a peptide that interferes with Gbetagamma binding
Q35197866Control of ethanol sensitivity of the glycine receptor α3 subunit by transmembrane 2, the intracellular splice cassette and C-terminal domains
Q30371246Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses
Q34785588Evidence for α-helices in the large intracellular domain mediating modulation of the α1-glycine receptor by ethanol and Gβγ.
Q46108389Functional complementation of Glra1(spd-ot), a glycine receptor subunit mutant, by independently expressed C-terminal domains.
Q50868810G protein modulation of K2P potassium channel TASK-2 : a role of basic residues in the C terminus domain.
Q37614296Glycine as a neurotransmitter in the forebrain: a short review.
Q30426940Glycine receptor mouse mutants: model systems for human hyperekplexia
Q93498403Glycine receptors
Q28473233Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons
Q35953058Identification and Characterization of a G Protein-binding Cluster in α7 Nicotinic Acetylcholine Receptors
Q36418934Inhibition of the ethanol-induced potentiation of α1 glycine receptor by a small peptide that interferes with Gβγ binding.
Q41937138Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity
Q93551700Ligand-Gated Ion Channels
Q37447989Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity
Q38974419Mechanism of Allosteric Modulation of the Cys-loop Receptors
Q30391650Molecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation
Q28476717Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids
Q33936421Molecular targets and mechanisms for ethanol action in glycine receptors
Q39767252Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting
Q39272135Paracetamol fails to positively modulate and directly activate chloride currents in human α1-glycine receptors
Q47863912Presence of ethanol-sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens.
Q94480089Reduced sedation and increased ethanol consumption in knock-in mice expressing an ethanol insensitive alpha 2 subunit of the glycine receptor
Q41002616Reversal of Ethanol-induced Intoxication by a Novel Modulator of Gβγ Protein Potentiation of the Glycine Receptor.
Q42117968Single expressed glycine receptor domains reconstitute functional ion channels without subunit-specific desensitization behavior
Q38893053Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors
Q33439862Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors
Q30486732The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.
Q48143336The Glycine Receptor-A Functionally Important Primary Brain Target of Ethanol.
Q26743781The Intracellular Loop of the Glycine Receptor: It's not all about the Size
Q35688518The basic property of Lys385 is important for potentiation of the human α1 glycine receptor by ethanol
Q41308485The importance of TM3-4 loop subdomains for functional reconstitution of glycine receptors by independent domains.

Search more.