Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc

scientific article published on 20 March 2017

Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.00427-16
P932PMC publication ID5440655
P698PubMed publication ID28320871

P50authorSuguru OkudaQ57313221
Saya NakagomiQ64022687
Kazuko Kaneda-NakashimaQ91437091
P2093author name stringYoshikatsu Kanai
Masami Kanai-Azuma
Shushi Nagamori
Ryuichi Ohgaki
Saori Hara
Takahiro Ohmori
P2860cites workThe light subunit of system b(o,+) is fully functional in the absence of the heavy subunitQ39648305
Membrane trafficking of CD98 and its ligand galectin 3 in BeWo cells--implication for placental cell fusionQ40142569
RNA interference-induced reduction in CD98 expression suppresses cell fusion during syncytialization of human placental BeWo cellsQ40489563
Manipulation of CD98 Expression Affects both Trophoblast Cell Fusion and Amino Acid Transport Activity during Syncytialization of Human Placental BeWo CellsQ40648709
Expression and regulation of 4F2hc and hLAT1 in human trophoblastsQ40763540
Placental transport of leucine and lysine is reduced in intrauterine growth restrictionQ42462471
Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cellsQ42516303
Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell linesQ43737336
Placental transport of leucine, phenylalanine, glycine, and proline in intrauterine growth-restricted pregnanciesQ43794589
Immunolocalization of GLUT1 and connexin 26 in the rat placentaQ46983312
Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8.Q49093601
Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth.Q51702805
The targeted disruption of the CD98 gene results in embryonic lethality.Q52101480
Cell-to-cell fusion as a link between viruses and cancer.Q53514752
Involvement of connexin 43 in human trophoblast cell fusion and differentiationQ59344565
Expression of a system L neutral amino acid transporter at the blood-brain barrierQ73234543
Establishment of stable cell lines with high expression of heterodimers of human 4F2hc and human amino acid transporter LAT1 or LAT2 and delineation of their differential interaction with α-alkyl moietiesQ84691939
Syncytin is a captive retroviral envelope protein involved in human placental morphogenesisQ22253248
Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease familyQ24316388
An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptorQ24524784
The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptorsQ24537689
Metabolic activation-related CD147-CD98 complexQ24539137
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
The functional interaction between CD98 and CD147 in regulation of virus-induced cell fusion and osteoclast formationQ28202420
Role of the System L permease LAT1 in amino acid and iodothyronine transport in placentaQ28366257
A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblastQ28507060
Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope geneQ28507592
Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)Q28570781
Slc7a7 disruption causes fetal growth retardation by downregulating Igf1 in the mouse model of lysinuric protein intoleranceQ28584950
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placentaQ28588079
Quantitative investigation of human cell surface N-glycoprotein dynamicsQ33763515
The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.Q33919682
Function of fusion regulatory proteins (FRPs) in immune cells and virus-infected cells.Q34020891
Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevanceQ34477910
Syncytin-2 plays an important role in the fusion of human trophoblast cellsQ34992874
Nutrient-sensing mechanisms and pathways.Q35036374
Expression and functional characterisation of System L amino acid transporters in the human term placenta.Q35710939
Development of structures and transport functions in the mouse placentaQ36124326
Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?Q36139606
Determinants of trophoblast lineage and cell subtype specification in the mouse placentaQ36166995
Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1.Q36498171
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiationQ36903810
Cell fusion during developmentQ36991258
The SLC3 and SLC7 families of amino acid transportersQ38090767
Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2.Q38295083
Biochemical and biophysical characterization of human recombinant IgE-binding protein, an S-type animal lectinQ38327495
Expression and function of endogenous retroviruses in the placentaQ38714215
MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusionQ39239952
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectsyncytiotrophoblastQ2745412
P577publication date2017-03-20
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleEssential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc
P478volume37

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cites work (P2860)
Q100491018ATP modulates SLC7A5 (LAT1) synergistically with cholesterol
Q92503254Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc
Q94562060Glutamine transporters as pharmacological targets: From function to drug design
Q58773166Methionine Partially Replaced by Methionyl-Methionine Dipeptide Improves Reproductive Performance over Methionine Alone in Methionine-Deficient Mice
Q38695531Methylmercury Uptake into BeWo Cells Depends on LAT2-4F2hc, a System L Amino Acid Transporter
Q98613151Mitochondrial uncoupling and the disruption of the metabolic network in hepatocellular carcinoma
Q55003034RNA-Seq identifies genes whose proteins are transformative in the differentiation of cytotrophoblast to syncytiotrophoblast, in human primary villous and BeWo trophoblasts.
Q55514831The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health.

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