Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2.

scientific article

Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/CS20150554
P932PMC publication ID5681479
P698PubMed publication ID26608079
P5875ResearchGate publication ID284713407

P50authorTheresa L. PowellQ37373063
P2093author name stringYoshikatsu Kanai
Thomas Jansson
Fredrick J Rosario
Kris Genelyn Dimasuay
P2860cites workNedd4-2 and the regulation of epithelial sodium transportQ21129256
Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1Q24298918
Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubuleQ24303787
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveQ24306328
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survivalQ24311448
Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expressionQ24534668
mTOR signaling in growth control and diseaseQ24634174
The role of placental nutrient sensing in maternal-fetal resource allocationQ27008068
The ubiquitin systemQ27860803
Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene familyQ28185230
CATs and HATs: the SLC7 family of amino acid transportersQ28242975
Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2Q28511126
Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channelsQ28576474
Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growthQ60539339
Amino acid (system A) transporter activity in microvillous membrane vesicles from the placentas of appropriate and small for gestational age babiesQ72714632
Association between the activity of the system A amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine growth restrictionQ73903484
Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2Q28581935
Effect of in utero and early-life conditions on adult health and diseaseQ29615797
Involvement of transporter recruitment as well as gene expression in the substrate-induced adaptive regulation of amino acid transport system A.Q30665686
Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cellsQ33803438
mTOR complex-2 activates ENaC by phosphorylating SGK1.Q33834293
Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulationQ34086674
NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene.Q34113703
14-3-3 Mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels.Q34529071
Nutrient-sensing mechanisms and pathways.Q35036374
Expression and functional characterisation of System L amino acid transporters in the human term placenta.Q35710939
Living with the past: evolution, development, and patterns of diseaseQ35890929
Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR.Q36186464
Placental phenotypes of intrauterine growthQ36267751
Role of ubiquitylation in cellular membrane transportQ36443011
Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies.Q36508970
Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.Q36778250
Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches.Q36834978
Role of placental nutrient sensing in developmental programmingQ37067340
Methods for siRNA-mediated reduction of mRNA and protein expression in human placental explants, isolated primary cells and cell lines.Q37081796
Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transportersQ37381899
Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon.Q37593992
Adiponectin inhibits insulin function in primary trophoblasts by PPARα-mediated ceramide synthesis.Q37670103
Regulation of epithelial sodium channel trafficking by ubiquitinationQ37693525
Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cellsQ40408675
Enac degradation in A6 cells by the ubiquitin-proteosome proteolytic pathwayQ40816797
Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availabilityQ41963892
Intrauterine growth restriction is associated with a reduced activity of placental taurine transportersQ42459798
Placental transport of leucine and lysine is reduced in intrauterine growth restrictionQ42462471
SNAT4 isoform of system A amino acid transporter is expressed in human placenta.Q42483689
Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cellsQ42516303
Alterations in the activity of placental amino acid transporters in pregnancies complicated by diabetesQ42522946
Chronic maternal infusion of full-length adiponectin in pregnant mice down-regulates placental amino acid transporter activity and expression and decreases fetal growthQ45070271
New insights into mTOR signaling: mTORC2 and beyondQ46041816
Regulation of placental amino acid transporter activity by mammalian target of rapamycinQ46262270
IFPA 2005 Award in Placentology Lecture. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? -- a reviewQ46916000
Purification, Characterization, andin vitroDifferentiation of Cytotrophoblasts from Human Term Placentae*Q56794799
Effect of IL-6 and TNF-α on fatty acid uptake in cultured human primary trophoblast cellsQ60539301
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)499-512
P577publication date2015-11-25
P1433published inClinical ScienceQ372419
P1476titleRegulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2.
P478volume130

Reverse relations

cites work (P2860)
Q92139148Apelin is a novel regulator of human trophoblast amino acid transport
Q58114588Chemotherapy in pregnancy: exploratory study of the effects of paclitaxel on the expression of placental drug transporters
Q92062476Comparative Study of PPARγ Targets in Human Extravillous and Villous Cytotrophoblasts
Q47363786DNA methylation of amino acid transporter genes in the human placenta.
Q92180524EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer
Q28076834Effects of maternal obesity on placental function and fetal development
Q40284059Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc
Q47126749FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition
Q90038144Glucocorticoid regulation of amino acid transport in primary human trophoblast cells
Q36186464Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR.
Q36238919Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight
Q57286714Lysosome: The Metabolic Signaling Hub
Q33822467Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice
Q37209059Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC.
Q93369636Novel roles of mechanistic target of rapamycin signaling in regulating fetal growth†
Q26767506Placental Responses to Changes in the Maternal Environment Determine Fetal Growth
Q57282400Reduced Uterine Perfusion Pressure Causes Loss of Pancreatic Beta Cell Area but Normal Function in Fetal Rat Offspring
Q39033646Ubiquitination and the Regulation of Membrane Proteins
Q91287051Ubiquitylation and endocytosis of the human LAT1/SLC7A5 amino acid transporter
Q48324137mTOR folate sensing links folate availability to trophoblast cell function

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