Enhanced and prolonged cross-presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles

scientific article published on January 2006

Enhanced and prolonged cross-presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1365-2567.2005.02268.X
P932PMC publication ID1782199
P698PubMed publication ID16423043
P5875ResearchGate publication ID7349684

P50authorW. Mark SaltzmanQ23092145
P2093author name stringElla R Hinson
Peter Cresswell
Hong Shen
Richard L Edelson
Alessandra Giodini
Douglas J Hanlon
Virginia Cody
Anne L Ackerman
P2860cites workThe tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO moleculesQ28284349
Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivoQ28595026
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factorQ29619247
Cytoplasmic delivery of a macromolecular fluorescent probe by poly(d, l-lactic-co-glycolic acid) microspheresQ30855750
Analysis of poly(D,L-lactic-co-glycolic acid) nanosphere uptake by human dendritic cells and macrophages in vitroQ30869485
Uptake of poly(D,L-lactic-co-glycolic acid) microspheres by antigen-presenting cells in vivoQ31045989
Mechanisms of exogenous antigen presentation by MHC class I molecules in vitro and in vivo: implications for generating CD8+ T cell responses to infectious agents, tumors, transplants, and vaccinesQ33683185
Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigenQ33855119
Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assayQ33903838
Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigensQ34291693
A new foreign policy: MHC class I molecules monitor the outside worldQ34398620
Targeting vaccines to dendritic cellsQ34588561
Biodegradable nanoparticles for drug and gene delivery to cells and tissueQ35082117
Vaccination of patients with solid tumoursQ35149453
New tools for antigen delivery to the MHC class I pathwayQ35753113
Cellular mechanisms governing cross-presentation of exogenous antigensQ35821234
Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigensQ35826361
Part I: Vaccines for solid tumoursQ35937453
Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanomaQ36119828
Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptor-mediated uptakeQ36367262
Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccinesQ36447615
CTL responses induced by a single immunization with peptide encapsulated in biodegradable microparticlesQ38555817
Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic T lymphocytes and CD4+ Th1 cells.Q38563231
Induction of measles virus-specific cytotoxic T-cell responses after intranasal immunization with synthetic peptidesQ39340704
CpG-DNA aided cross-priming by cross-presenting B cellsQ40597304
Regulation of MHC class I transport in human dendritic cells and the dendritic-like cell line KG-1.Q40656615
Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene deliveryQ40713744
Enhancement of antitumor immunity by prolonging antigen presentation on dendritic cellsQ40753335
Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line modelQ40964829
Effects of cytokines on mycobacterial phagosome maturationQ41043022
Cloned dendritic cells can present exogenous antigens on both MHC class I and class II moleculesQ41120866
Intracellular transport of class I MHC molecules in antigen processing mutant cell linesQ41522889
Presentation of exogenous antigen with class I major histocompatibility complex moleculesQ41724565
Defective presentation of endogenous antigen by a cell line expressing class I moleculesQ41736911
Vaccination of pediatric solid tumor patients with tumor lysate-pulsed dendritic cells can expand specific T cells and mediate tumor regression.Q43814408
Biodegradable polymer-based interleukin-12 gene delivery: role of induced cytokines, tumor infiltrating cells and nitric oxide in anti-tumor activityQ44078795
Dendritic cell-based vaccination in solid cancer.Q44265670
Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitroQ44297910
Protein encapsulation into biodegradable microspheres by a novel S/O/W emulsion method using poly(ethylene glycol) as a protein micronization adjuvantQ44354994
Analysis of the role of MHC class II presentation in the stimulation of cytotoxic T lymphocytes by antigens targeted into the exogenous antigen-MHC class I presentation pathwayQ44473282
Antigen loading of dendritic cells with whole tumor cell preparationsQ44473359
Polymer degradation and in vitro release of a model protein from poly(d,l-lactide-co-glycolide) nano- and microparticlesQ44589782
Differential transport requirements of HLA and H-2 class I glycoproteinsQ44765538
Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cellsQ45875123
Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumorsQ47409832
Regulation of phagosome maturation by signals from toll-like receptorsQ47604798
Synthetic peptides entrapped in microparticles can elicit cytotoxic T cell activityQ47628605
Intracranial delivery of recombinant nerve growth factor: release kinetics and protein distribution for three delivery systemsQ48250150
Transplantation of brain cells assembled around a programmable synthetic microenvironmentQ48769080
Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC moleculesQ50146397
Delivery of tumor antigens to dendritic cells using biodegradable microspheres.Q51570066
pH-triggered microparticles for peptide vaccination.Q51635616
A novel microencapsulated peptide vaccine against hepatitis B.Q52020177
Rapid Peptide Turnover and Inefficient Presentation of Exogenous Antigen Critically Limit the Activation of Self-Reactive CTL by Dendritic CellsQ58235001
Analysis of the role of vaccine adjuvants in modulating dendritic cell activation and antigen presentation in vitroQ58867366
A fluorometric assay for cholesterol reductase activityQ67586883
Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residuesQ71527769
Induction of cytotoxic T-cell responses following oral immunization with synthetic peptides encapsulated in PLG microparticlesQ73098451
Enhanced antigen-specific antitumor immunity with altered peptide ligands that stabilize the MHC-peptide-TCR complexQ73168752
Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibodyQ73479961
Release kinetics and immunogenicity of parvovirus microencapsulated in PLA/PLGA microspheresQ73990836
Fully mobilizing host defense: building better vaccinesQ77608031
P433issue1
P921main subjectnanoparticleQ61231
biodegradationQ696715
P304page(s)78-88
P577publication date2006-01-01
P1433published inImmunologyQ15754984
P1476titleEnhanced and prolonged cross-presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles
P478volume117

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cites work (P2860)
Q38685236A Freeze-Concentration and Polyampholyte-Modified Liposome-Based Antigen-Delivery System for Effective Immunotherapy.
Q43784838A biodegradable and biocompatible drug-delivery system based on polyoxalate microparticles
Q35318315A therapeutic microparticle-based tumor lysate vaccine reduces spontaneous metastases in murine breast cancer
Q48511578A vaccine targeting basic fibroblast growth factor elicits a protective immune response against murine melanoma
Q38941777ANALYSIS OF DENDRITIC CELL STIMULATION UTILIZING A MULTI-FACETED NANOPOLYMER DELIVERY SYSTEM AND THE IMMUNE MODULATOR 1-METHYL TRYPTOPHAN.
Q36122915Acetalated Dextran Microparticulate Vaccine Formulated via Coaxial Electrospray Preserves Toxin Neutralization and Enhances Murine Survival Following Inhalational Bacillus Anthracis Exposure.
Q26747586Adjuvants: Classification, Modus Operandi, and Licensing
Q91731105Advancements in Prophylactic and Therapeutic Nanovaccines
Q47848180An antigen-specific semi-therapeutic treatment with local delivery of tolerogenic factors through a dual-sized microparticle system blocks experimental autoimmune encephalomyelitis
Q43883594Antigen co-encapsulated with adjuvants efficiently drive protective T cell immunity
Q42863719Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation
Q33752783Antigen delivery with poly(propylacrylic acid) conjugation enhances MHC-1 presentation and T-cell activation
Q38838467Application of nanostructured drug delivery systems in immunotherapy of cancer: a review.
Q33894321Application of nanotechnologies for improved immune response against infectious diseases in the developing world
Q36591050Applications of polymeric adjuvants in studying autoimmune responses and vaccination against infectious diseases
Q34795079Bee Venom Phospholipase A2, a Good "Chauffeur" for Delivering Tumor Antigen to the MHC I and MHC II Peptide-Loading Compartments of the Dendritic Cells: The Case of NY-ESO-1.
Q37896455Bio-inspired, bioengineered and biomimetic drug delivery carriers
Q36502434Biodegradable particles as vaccine delivery systems: size matters
Q36978486Biodegradable polylactide microspheres enhance specific immune response induced by Hepatitis B surface antigen.
Q37483316Biomimetic protein nanoparticles facilitate enhanced dendritic cell activation and cross-presentation
Q35913715CD4(+) T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease
Q38288055Cancer immunotherapy: nanodelivery approaches for immune cell targeting and tracking
Q34993838Carnauba wax nanoparticles enhance strong systemic and mucosal cellular and humoral immune responses to HIV-gp140 antigen.
Q97883503Characterization of Bacillus anthracis Spore Proteins Using a Nanoscaffold Vaccine Platform
Q64250051Chitosan Plus Compound 48/80: Formulation and Preliminary Evaluation as a Hepatitis B Vaccine Adjuvant
Q39117175Combinational delivery of lipid-enveloped polymeric nanoparticles carrying different peptides for anti-tumor immunotherapy
Q38680602Combinatorial drug delivery approaches for immunomodulation
Q42259049Comparison of PLA microparticles and alum as adjuvants for H5N1 influenza split vaccine: adjuvanticity evaluation and preliminary action mode analysis
Q45357998Comparison of vaccine efficacy for different antigen delivery systems for infectious pancreatic necrosis virus vaccines in Atlantic salmon (Salmo salar L.) in a cohabitation challenge model
Q36884768Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity
Q35667536Controlled Endolysosomal Release of Agents by pH-responsive Polymer Blend Particles
Q40730765Controlling influenza by cytotoxic T-cells: calling for help from destroyers
Q38737582Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses
Q29248618Current applications and future prospects of nanomaterials in tumor therapy
Q38746362Delivery systems for Leishmania vaccine development
Q39294119Dendritic cells in the host response to implanted materials
Q39849945Dendritic cells loaded with HIV-1 p24 proteins adsorbed on surfactant-free anionic PLA nanoparticles induce enhanced cellular immune responses against HIV-1 after vaccination
Q50850972Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation.
Q47137438Design and evaluation of the immunogenicity and efficacy of a biomimetic particulate formulation of viral antigens
Q34074750Design of lipid nanocapsule delivery vehicles for multivalent display of recombinant Env trimers in HIV vaccination
Q37062606Design opportunities for actively targeted nanoparticle vaccines
Q37744071Designing CD8+ T cell vaccines: it's not rocket science (yet).
Q37808118Designing polymeric particles for antigen delivery
Q37588454Development of Yersinia pestis F1 antigen-loaded microspheres vaccine against plague
Q41662420Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach
Q36396099Diaminosulfide based polymer microparticles as cancer vaccine delivery systems
Q64116567Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model
Q84882761Early immune responses in Atlantic salmon (Salmo salar L.) after immunization with PLGA nanoparticles loaded with a model antigen and β-glucan
Q89978286Effective Activation of Human Antigen-Presenting Cells and Cytotoxic CD8+ T Cells by a Calcium Phosphate-Based Nanoparticle Vaccine Delivery System
Q39161562Efficient ex vivo induction of T cells with potent anti-tumor activity by protein antigen encapsulated in nanoparticles
Q47984619Electrospray Synthesis of Poly(lactide-co-glycolide) Nanoparticles Encapsulating Peptides to Enhance Proliferation of Antigen-Specific CD8+ T Cells
Q87612380Encapsulation of an EP67-Conjugated CTL Peptide Vaccine in Nanoscale Biodegradable Particles Increases the Efficacy of Respiratory Immunization and Affects the Magnitude and Memory Subsets of Vaccine-Generated Mucosal and Systemic CD8+ T Cells in a
Q57947036Endocytosis and intracellular processing of nanoparticles in dendritic cells: routes to effective immunonanomedicines
Q28085563Engineering New Approaches to Cancer Vaccines
Q96951726Engineering immunomodulatory biomaterials for type 1 diabetes
Q38154804Engineering synthetic vaccines using cues from natural immunity
Q34860928Enhanced stimulation of anti-ovarian cancer CD8(+) T cells by dendritic cells loaded with nanoparticle encapsulated tumor antigen
Q51132472Enhancement of antigen-specific CD4+ and CD8+ T cell responses using a self-assembled biologic nanolipoprotein particle vaccine.
Q38754451Evaluation of hydrophobic chitosan-based particulate formulations of porcine reproductive and respiratory syndrome virus vaccine candidate T cell antigens
Q30391225Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly
Q37591932Fabrication of nanoadjuvant with poly-ε-caprolactone (PCL) for developing a single-shot vaccine providing prolonged immunity
Q35157029Formulation and Characterization of Antigen-loaded PLGA Nanoparticles for Efficient Cross-priming of the Antigen
Q36212696Formulation and evaluation of oral microparticulate ovarian cancer vaccines
Q38757220Functionalization promotes pathogen-mimicking characteristics of polyanhydride nanoparticle adjuvants.
Q57227652Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants
Q64071651Harnessing Dendritic Cells for Poly (D,L-lactide--glycolide) Microspheres (PLGA MS)-Mediated Anti-tumor Therapy
Q37354264Hepatitis C virus E2 protein encapsulation into poly d, l-lactic-co-glycolide microspheres could induce mice cytotoxic T-cell response
Q34513978Improved antigen cross-presentation by polyethyleneimine-based nanoparticles
Q26766267Improving the clinical impact of biomaterials in cancer immunotherapy
Q35573167In Vivo Modulation of Dendritic Cells by Engineered Materials: Towards New Cancer Vaccines.
Q35563449In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery
Q81083959Induction of HIV-specific T and B cell responses with a replicating and conditionally infectious lentiviral vaccine
Q36714925Induction of Potent Antigen-specific Cytotoxic T Cell Response by PLGA-nanoparticles Containing Antigen and TLR Agonist
Q92354318Induction of antigen-specific immune tolerance using biodegradable nanoparticles containing antigen and dexamethasone
Q27309214Induction of heterosubtypic cross-protection against influenza by a whole inactivated virus vaccine: the role of viral membrane fusion activity
Q35548034Induction of potent adaptive immunity by the novel polyion complex nanoparticles
Q37970755Interaction of nanoparticles with immunocompetent cells: nanosafety considerations
Q34785774Intracellular delivery of a protein antigen with an endosomal-releasing polymer enhances CD8 T-cell production and prophylactic vaccine efficacy
Q38886698Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines?
Q35740218Lipid nanocapsule as vaccine carriers for his-tagged proteins: evaluation of antigen-specific immune responses to HIV I His-Gag p41 and systemic inflammatory responses
Q37812085Macrophage and dendritic cell phenotypic diversity in the context of biomaterials
Q39214943Mesoporous silica-calcium phosphate-tuberculin purified protein derivative composites as an effective adjuvant for cancer immunotherapy.
Q77791988Metal nanomaterials: immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease
Q38066148Micro and nanoparticle-based delivery systems for vaccine immunotherapy: an immunological and materials perspective
Q38073752Modern subunit vaccines: development, components, and research opportunities
Q37820820Multifunctional dendritic cell-targeting polymeric microparticles: engineering new vaccines for type 1 diabetes
Q51068276Multistaged Nanovaccines Based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy.
Q36452648Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody
Q37031671Nanocarrier-based immunotherapy in cancer management and research
Q48646732Nanomaterials for cancer immunotherapy.
Q38418305Nanomaterials for enhanced immunity as an innovative paradigm in nanomedicine.
Q36925868Nanomaterials in the application of tumor vaccines: advantages and disadvantages
Q58583890Nanoparticle Vaccines Against Infectious Diseases
Q35518723Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination
Q36269694Nanoparticle-Based Manipulation of Antigen-Presenting Cells for Cancer Immunotherapy
Q50226473Nanoparticle-based strategies for cancer immunotherapy and immunodiagnostics
Q37279161Nanoparticle-based vaccine delivery for cancer immunotherapy
Q43623067Nanoparticle-based vaccine for mucosal protection against Shigella flexneri in mice
Q26801067Nanotechnology: Future of Oncotherapy
Q34145500Neutral polymer micelle carriers with pH-responsive, endosome-releasing activity modulate antigen trafficking to enhance CD8(+) T cell responses.
Q38341522Next generation vaccines: single-dose encapsulated vaccines for improved global immunisation coverage and efficacy
Q42248367Optimal conditions required for influenza A infection-enhanced cross-priming of CD8⁺ T cells specific to cell-associated antigens.
Q37463836PEGylated PLGA nanoparticles for the improved delivery of doxorubicin
Q38692217PLGA particulate delivery systems for subunit vaccines: Linking particle properties to immunogenicity
Q38793294PLGA-Listeriolysin O microspheres: Opening the gate for cytosolic delivery of cancer antigens
Q36897208PLGA-polymer encapsulating tumor antigen and CpG DNA administered into the tumor microenvironment elicits a systemic antigen-specific IFN-γ response and enhances survival
Q39440275PLGA/PLA micro- and nanoparticle formulations serve as antigen depots and induce elevated humoral responses after immunization of Atlantic salmon (Salmo salar L.).
Q38114060Particle platforms for cancer immunotherapy
Q37860707Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines
Q50917304Peptide-Conjugated Nanoparticles Reduce Positive Co-stimulatory Expression and T Cell Activity to Induce Tolerance.
Q33721852Poly(lactide-co-glycolide) nanoparticle assembly for highly efficient delivery of potent therapeutic agents from medical devices
Q41598583Poly-(lactic-co-glycolic-acid)-based particulate vaccines: particle uptake by dendritic cells is a key parameter for immune activation.
Q34025136Polyelectrolyte capsules-containing HIV-1 p24 and poly I:C modulate dendritic cells to stimulate HIV-1-specific immune responses.
Q37167802Polymer nanoparticles for cross-presentation of exogenous antigens and enhanced cytotoxic T-lymphocyte immune response
Q35709192Programming the composition of polymer blend particles for controlled immunity towards individual protein antigens
Q33928383Prolonged antigen survival and cytosolic export in cross-presenting human gammadelta T cells
Q84974580Quantitative Aspects of Intracellularly-Targeted Drug Delivery
Q27001699Recent advances in oral vaccine development: yeast-derived β-glucan particles
Q61813215Recent advances in the treatment of pathogenic infections using antibiotics and nano-drug delivery vehicles
Q38068954Recent progress towards development of a Shigella vaccine
Q30405708Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine.
Q36966767Selectively targeting the toll-like receptor 9 (TLR9)--IRF 7 signaling pathway by polymer blend particles
Q42281935Self-adjuvanting influenza candidate vaccine presenting epitopes for cell-mediated immunity on a proteinaceous multivalent nanoplatform.
Q28830111Self-assembly of polyphosphazene immunoadjuvant with poly(ethylene oxide) enables advanced nanoscale delivery modalities and regulated pH-dependent cellular membrane activity
Q33385557Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery
Q38583148Small Wonders-The Use of Nanoparticles for Delivering Antigen
Q39405264Spray-dried microparticles: a potential vehicle for oral delivery of vaccines
Q82592385Surface modification of poly(D,L‐lactic‐co‐glycolic acid) nanoparticles with protamine enhanced cross‐presentation of encapsulated ovalbumin by bone marrow‐derived dendritic cells
Q28085375Synthetic Nanoparticles for Vaccines and Immunotherapy
Q44997831TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses
Q37120117TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis
Q30869313Targeted delivery of vaccine to dendritic cells by chitosan nanoparticles conjugated with a targeting peptide ligand selected by phage display technique
Q34532116Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen
Q37082455The cell biology of cross-presentation and the role of dendritic cell subsets
Q43743678The role of membrane fusion activity of a whole inactivated influenza virus vaccine in (re)activation of influenza-specific cytotoxic T lymphocytes
Q37327058The role of phagosomal pH on the size-dependent efficiency of cross-presentation by dendritic cells
Q38731626The uptake and intracellular fate of PLGA nanoparticles in epithelial cells
Q33383239Urea-mediated cross-presentation of soluble Epstein-Barr virus BZLF1 protein
Q40061497Vaccination with poly(D,L-lactide-co-glycolide) nanoparticles loaded with soluble Leishmania antigens and modified with a TNFα-mimicking peptide or monophosphoryl lipid A confers protection against experimental visceral leishmaniasis
Q36712817Vaccine delivery using nanoparticles.

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