Clinical Relevance of Type II Fatty Acid Synthesis Bypass in Staphylococcus aureus

scientific article published on 13 February 2017

Clinical Relevance of Type II Fatty Acid Synthesis Bypass in Staphylococcus aureus is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/AAC.02515-16
P932PMC publication ID5404599
P698PubMed publication ID28193654

P50authorAlexandra GrussQ37842263
Christine PourcelQ56458925
Claire MorvanQ57093871
David HalpernQ57093883
Karine GlouxQ57093893
P2093author name stringCharles Soler
Gilles Lamberet
Hoang Vu Thien
Mélanie Guillemet
P2860cites workNasal microenvironments and interspecific interactions influence nasal microbiota complexity and S. aureus carriageQ24614067
New design platform for malonyl-CoA-acyl carrier protein transacylaseQ27660001
Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme–Product ComplexQ27678258
Staphylococcus aureus FabI: Inhibition, Substrate Recognition, and Potential Implications for In Vivo EssentialityQ27679034
Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase InhibitorQ27683440
Triclosan promotes Staphylococcus aureus nasal colonizationQ28384355
Triclosan: a widely used biocide and its link to antibioticsQ29391509
A tale of two functions: enzymatic activity and translational repression by carboxyltransferaseQ33700075
Waves of resistance: Staphylococcus aureus in the antibiotic era.Q33854398
Defining and combating the mechanisms of triclosan resistance in clinical isolates of Staphylococcus aureusQ34142386
Emergence of a novel subpopulation of CC398 Staphylococcus aureus infecting animals is a serious hazard for humansQ34637716
Staphylococcus epidermidis isolated in 1965 are more susceptible to triclosan than current isolatesQ34685701
Staphylococcus aureus but not Listeria monocytogenes adapt to triclosan and adaptation correlates with increased fabI expression and agr deficiencyQ34880970
The impact of triclosan on the spread of antibiotic resistance in the environmentQ34969983
Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors.Q35216999
The MUT056399 inhibitor of FabI is a new antistaphylococcal compoundQ35270339
Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?Q35350186
Corynebacterium accolens Releases Antipneumococcal Free Fatty Acids from Human Nostril and Skin Surface Triacylglycerols.Q35886154
Evaluation of molecular typing methods in characterizing a European collection of epidemic methicillin-resistant Staphylococcus aureus strains: the HARMONY collectionQ35913887
Membrane disruption by antimicrobial fatty acids releases low-molecular-weight proteins from Staphylococcus aureus.Q36276367
Fatty acids in bovine milk fat.Q37000831
Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intakeQ37147269
Staphylococcus aureus fatty acid auxotrophs do not proliferate in miceQ37263376
Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobialsQ37329885
Triclosan: environmental exposure, toxicity and mechanisms of actionQ37861068
Biocide tolerance in bacteriaQ38076006
Activity of Debio1452, a FabI inhibitor with potent activity against Staphylococcus aureus and coagulase-negative Staphylococcus spp., including multidrug-resistant strainsQ39565510
Growth requirements of some small-colony-forming variants of Staphylococcus aureusQ40235354
Emergence of a small colony variant of vancomycin-intermediate Staphylococcus aureus in a patient with septic arthritis during long-term treatment with daptomycinQ40758601
Dissemination of Novel Antimicrobial Resistance Mechanisms through the Insertion Sequence Mediated Spread of Metabolic GenesQ42137262
In vitro activity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibioticsQ43026765
Essentiality of FASII pathway for Staphylococcus aureusQ43187921
A novel resistance mechanism to triclosan that suggests horizontal gene transfer and demonstrates a potential selective pressure for reduced biocide susceptibility in clinical strains of Staphylococcus aureusQ44219816
Serum fatty acid levels, dietary style and coronary heart disease in three neighbouring areas in Japan: the Kumihama studyQ44307887
Triclosan resistance in methicillin-resistant Staphylococcus aureus (MRSA).Q44608394
First isolation of oleate-dependent Enterococcus faecalis small-colony variants from the umbilical exudate of a paediatric patient with omphalitisQ46989674
Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogensQ57244151
Reduced Enterobacterial and Increased Staphylococcal Colonization of the Infantile Bowel: An Effect of Hygienic Lifestyle?Q58848624
The Group B Streptococcus NADH oxidase Nox-2 is involved in fatty acid biosynthesis during aerobic growth and contributes to virulenceQ59809276
The fatty acid profile of the skin surface lipid layer in papulopustular rosaceaQ63248590
Lipid composition of sputum from patients with asthma and patients with cystic fibrosisQ67027021
The saturated methyl branched fatty acids of adult human skin surface lipidQ67051489
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectfatty acidQ61476
Staphylococcus aureusQ188121
P577publication date2017-02-13
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleClinical Relevance of Type II Fatty Acid Synthesis Bypass in Staphylococcus aureus
P478volume61

Reverse relations

cites work (P2860)
Q39408643Exogenous fatty acid metabolism in bacteria
Q52629550Staphylococcus aureus utilizes host-derived lipoprotein particles as sources of exogenous fatty acids.
Q57492054Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis

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