BRCA1 associates with the inactive X chromosome in late S-phase, coupled with transient H2AX phosphorylation

scientific article published on 15 November 2005

BRCA1 associates with the inactive X chromosome in late S-phase, coupled with transient H2AX phosphorylation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00412-005-0029-1
P698PubMed publication ID16240122

P2093author name stringTimothy F Lane
Brian P Chadwick
P2860cites workChromatin dynamics at DNA replication, transcription and repairQ22065678
BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancerQ24273430
Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variantQ24291187
BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutationsQ24291985
Role of histone H2A ubiquitination in Polycomb silencingQ24305090
BRCA1 participates in DNA decatenationQ24305584
BRCA1 supports XIST RNA concentration on the inactive X chromosomeQ24316340
Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligaseQ24529056
Factors associated with the mammalian RNA polymerase II holoenzymeQ24546284
Time-Sequence of Human Chromosome DuplicationQ59066816
The human X-inactivation centre is not required for maintenance of X-chromosome inactivationQ59073076
Absence of the XIST gene from late-replicating isodicentric X chromosomes in leukaemiaQ60641474
Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient miceQ73139875
Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivationQ78079159
Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivationQ80918747
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutationsQ24622650
Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domainsQ24645684
XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structureQ24672147
Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosomeQ24672610
Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivationQ24678487
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139Q28131715
Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatinQ28138029
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage responseQ28140763
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damageQ28144576
H2AX: the histone guardian of the genomeQ28274279
Histone macroH2A1 is concentrated in the inactive X chromosome of female mammalsQ28274301
BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent mannerQ28287385
Association of BRCA1 with Rad51 in mitotic and meiotic cellsQ28302118
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivationQ28505166
The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleusQ29614336
The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleusQ29617834
Gene action in the X-chromosome of the mouse (Mus musculus L.)Q29618263
Co-localization of chicken DNA topoisomerase IIalpha, but not beta, with sites of DNA replication and possible involvement of a C-terminal region of alpha through its binding to PCNA.Q30687752
A shift from reversible to irreversible X inactivation is triggered during ES cell differentiationQ33908327
PCNA connects DNA replication to epigenetic inheritance in yeast.Q33926058
The human decatenation checkpoint.Q33946976
H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosisQ33965393
ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells.Q34049864
Xist RNA and the mechanism of X chromosome inactivationQ34158806
The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repairQ34203060
Distribution and dynamics of chromatin modification induced by a defined DNA double-strand breakQ34354650
Maintenance of chromatin states: an open-and-shut caseQ35145809
Barring gene expression after XIST: maintaining facultative heterochromatin on the inactive X.Q35688633
BRCA1 and transcriptionQ35836752
DNA repair: the importance of phosphorylating histone H2AX.Q36032031
Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosomeQ36322853
Asynchronous duplication of human chromosomes and the origin of sex chromatinQ36394766
Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosomeQ37694528
Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphaseQ40512889
BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.Q52064286
THE GENETICS OF BREAST CANCER SUSCEPTIBILITYQ57272243
P433issue6
P921main subjectphosphorylationQ242736
P304page(s)432-439
P577publication date2005-11-15
P1433published inChromosomaQ15765851
P1476titleBRCA1 associates with the inactive X chromosome in late S-phase, coupled with transient H2AX phosphorylation
P478volume114

Reverse relations

cites work (P2860)
Q35175983A deletion at the mouse Xist gene exposes trans-effects that alter the heterochromatin of the inactive X chromosome and the replication time and DNA stability of both X chromosomes
Q40251391Abnormalities of the inactive X chromosome are a common feature of BRCA1 mutant and sporadic basal-like breast cancer
Q35447270Advancing small-molecule-based chemical biology with next-generation sequencing technologies.
Q30480563BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin
Q33290461Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents
Q33988971DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin
Q30436771Double-strand DNA breaks recruit the centromeric histone CENP-A.
Q24608343Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
Q30560450Loss of WSTF results in spontaneous fluctuations of heterochromatin formation and resolution, combined with substantial changes to gene expression
Q35171563Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions
Q37398589New developments in post-translational modifications and functions of histone H2A variants
Q36834533Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing
Q42738107Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila
Q34014307Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast
Q34482956The WSTF-ISWI chromatin remodeling complex transiently associates with the human inactive X chromosome during late S-phase prior to BRCA1 and γ-H2AX
Q37038673The gamma-H2A.X: is it just a surrogate marker of double-strand breaks or much more?
Q37325705Toxoplasma H2A variants reveal novel insights into nucleosome composition and functions for this histone family

Search more.