The gamma-H2A.X: is it just a surrogate marker of double-strand breaks or much more?

scientific article published on January 2008

The gamma-H2A.X: is it just a surrogate marker of double-strand breaks or much more? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/EM.20358
P698PubMed publication ID18095327
P5875ResearchGate publication ID5754400

P50authorMichael J. HendzelQ42407069
Ismail H. IsmailQ55459223
P2093author name stringMichael J Hendzel
Ismail Hassan Ismail
P2860cites workCrystal structure of the nucleosome core particle at 2.8 A resolutionQ22122355
MDC1 is a mediator of the mammalian DNA damage checkpointQ24296229
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaksQ24299852
Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodelingQ24535638
A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosomeQ24652092
Megabase chromatin domains involved in DNA double-strand breaks in vivoQ24680284
The language of covalent histone modificationsQ27860931
A role for Saccharomyces cerevisiae histone H2A in DNA repair.Q27930827
Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sitesQ27931488
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recoveryQ27933727
INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.Q27933934
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139Q28131715
Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AXQ28139663
Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139Q28139691
ATM phosphorylates histone H2AX in response to DNA double-strand breaksQ28188651
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stressQ28201846
Chromosomal stability and the DNA double-stranded break connectionQ28205315
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationQ28206029
Histone H2A variants H2AX and H2AZQ28207014
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1Q28215916
Chromatin Structure: A Repeating Unit of Histones and DNAQ28246057
H2AX: the histone guardian of the genomeQ28274279
Histone macroH2A1 is concentrated in the inactive X chromosome of female mammalsQ28274301
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaksQ28291639
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switchingQ28366125
Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stabilityQ28509626
Genomic instability in mice lacking histone H2AXQ28589826
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaksQ29617463
Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensationQ29617905
Recombinational DNA double-strand breaks in mice precede synapsisQ29618790
Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repairQ29620305
Core histone N-termini play an essential role in mitotic chromosome condensationQ30449910
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinaseQ31070565
SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitizationQ33195747
Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatinQ33200727
Kinetics of core histones in living human cells: little exchange of H3 and H4 and some rapid exchange of H2B.Q33953079
Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoffQ33963811
The structure of DNA in the nucleosome coreQ33965908
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AXQ34031720
ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells.Q34049864
Histone variant H2ABbd confers lower stability to the nucleosomeQ34166137
Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damageQ34250284
DNA double-strand break-induced phosphorylation of Drosophila histone variant H2Av helps prevent radiation-induced apoptosisQ34376575
The many tales of a tail: carboxyl-terminal tail heterogeneity specializes histone H2A variants for defined chromatin functionQ34626888
V(D)J recombination: RAG proteins, repair factors, and regulationQ34667417
Evolutionary conservation of histone macroH2A subtypes and domainsQ34668581
H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaksQ34772965
Maintenance of chromatin states: an open-and-shut caseQ35145809
Phylogenomics of the nucleosomeQ35570334
Histones and histone modificationsQ35842800
The cellular response to general and programmed DNA double strand breaksQ35848409
The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombinationQ35848418
Histone H2A phosphorylation in DNA double-strand break repairQ36174600
Participation of core histone "tails" in the stabilization of the chromatin solenoidQ36208922
Translating the histone code into leukemiaQ36259209
Mechanisms of eukaryotic DNA double strand break repairQ36348265
H2AX haploinsufficiency modifies genomic stability and tumor susceptibilityQ36533572
Differential accessibility of the amino and carboxy termini of histone H2A in the nucleosome and its histone subunitsQ38480579
Elimination of radiation-induced gamma-H2AX foci in mammalian nucleus can occur by histone exchangeQ40133642
gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repairQ40347113
BRCA1 associates with the inactive X chromosome in late S-phase, coupled with transient H2AX phosphorylationQ40359514
Phosphorylation of histone H2AX at M phase in human cells without DNA damage responseQ40375352
Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II.Q40478067
Acetylation by Tip60 is required for selective histone variant exchange at DNA lesionsQ40495236
Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitorsQ40511617
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiationQ40570996
UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stressQ40595912
DNA repair mechanisms involved in gemcitabine cytotoxicity and in the interaction between gemcitabine and cisplatinQ40680519
Increased Ser-10 phosphorylation of histone H3 in mitogen-stimulated and oncogene-transformed mouse fibroblastsQ42811761
Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiaeQ43230977
Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibodyQ44140576
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.Q44378806
The measurement of DNA strand breaks in rat colonic mucosa by fluorometric analysis of DNA unwindingQ46080267
H2AX prevents DNA breaks from progressing to chromosome breaks and translocationsQ46904251
A likely histone H2A.F/Z variant in Saccharomyces cerevisiaeQ48057064
Photobleaching of GFP-labeled H2AX in chromatin: H2AX has low diffusional mobility in the nucleus.Q51842552
γ-H2AX illuminates meiosisQ58486287
The cellular response to DNA double-strand breaks: defining the sensors and mediatorsQ63383934
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumorsQ64387467
Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaksQ64388842
53BP1, an activator of ATM in response to DNA damageQ64388924
Spatio-temporal dynamics of chromatin containing DNA breaksQ80159893
P433issue1
P304page(s)73-82
P577publication date2008-01-01
P1433published inEnvironmental and Molecular MutagenesisQ15724469
P1476titleThe gamma-H2A.X: is it just a surrogate marker of double-strand breaks or much more?
P478volume49

Reverse relations

cites work (P2860)
Q341650634D chromatin dynamics in cycling cells: Theodor Boveri's hypotheses revisited
Q40293697A proposal for a novel rationale for critical effect size in dose-response analysis based on a multi-endpoint in vivo study with methyl methanesulfonate
Q55265956Altered DNA repair; an early pathogenic pathway in Alzheimer's disease and obesity.
Q35198350Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery
Q24632998BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair
Q34188958CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage
Q34565167Cell type-dependent induction of DNA damage by 1800 MHz radiofrequency electromagnetic fields does not result in significant cellular dysfunctions
Q37259025Cellular responses to DNA double-strand breaks after low-dose gamma-irradiation
Q39836469Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure
Q35098038DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes
Q60955618Distinctive Nuclear Features of Dinoflagellates with A Particular Focus on Histone and Histone-Replacement Proteins
Q36574568Diversity and Divergence of Dinoflagellate Histone Proteins
Q37261069Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
Q35558059Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells
Q24299399Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells
Q39031041Histone variants on the move: substrates for chromatin dynamics
Q28274796Histone variants--ancient wrap artists of the epigenome
Q34121601Induction and repair of DNA double-strand breaks assessed by gamma-H2AX foci after irradiation with pulsed or continuous proton beams.
Q28280704MRE11 and COM1/SAE2 are required for double-strand break repair and efficient chromosome pairing during meiosis of the protist Tetrahymena
Q37279340Meiotic wave adds extra asymmetry to the development of female chicken gonads.
Q36825256Neuronal accumulation of unrepaired DNA in a novel specific chromatin domain: structural, molecular and transcriptional characterization
Q37398589New developments in post-translational modifications and functions of histone H2A variants
Q34465287Nucleosome adaptability conferred by sequence and structural variations in histone H2A-H2B dimers
Q37401106OGT restrains the expansion of DNA damage signaling
Q36775097On the development of extragonadal and gonadal human germ cells.
Q48120660Periconception onset diabetes is associated with embryopathy and fetal growth retardation, reproductive tract hyperglycosylation and impaired immune adaptation to pregnancy
Q37335451Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes
Q90512382Persistent accumulation of unrepaired DNA damage in rat cortical neurons: nuclear organization and ChIP-seq analysis of damaged DNA
Q50670222Phosphorylated H2AX in parthenogenetically activated, in vitro fertilized and cloned bovine embryos.
Q33885281Phosphorylation of histone H2A.X by DNA-dependent protein kinase is not affected by core histone acetylation, but it alters nucleosome stability and histone H1 binding
Q30539255Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β
Q35838986Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation
Q39343299Possible novel roles of poly(rC)-binding protein 1 in SH-SY5Y neurocytes: an analysis using a dynamic Bayesian network
Q92879597Preventing the Solid Cancer Progression via Release of Anticancer-Cytokines in Co-Culture with Cold Plasma-Stimulated Macrophages
Q37800060Protein acetylation within the cellular response to radiation.
Q42013794Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage
Q34056605The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival
Q64899742The histone variant H2A.Z in gene regulation.
Q38095797The variant histone H2A.V of Drosophila--three roles, two guises.
Q38774044The γH2AX DNA damage assay from a drop of blood
Q42705953The γH2AX assay for genotoxic and nongenotoxic agents: comparison of H2AX phosphorylation with cell death response
Q37325705Toxoplasma H2A variants reveal novel insights into nucleosome composition and functions for this histone family
Q39543143Use of the hollow fiber assay for the evaluation of DNA damaging agents.
Q39657050Use of the γH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines
Q41772916p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress.
Q36010145uPAR and cathepsin B inhibition enhanced radiation-induced apoptosis in gliomainitiating cells.

Search more.