Association of cytoplasmic p27 expression with an unfavorable response to cisplatin-based chemotherapy and poor outcomes in non-small cell lung cancer

scientific article published on 20 October 2015

Association of cytoplasmic p27 expression with an unfavorable response to cisplatin-based chemotherapy and poor outcomes in non-small cell lung cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1007821610
P356DOI10.1007/S13277-015-4272-7
P698PubMed publication ID26482622

P2093author name stringMing-Chih Chou
Chih-Yi Chen
Huei Lee
Tsang-Chi Lin
Lung-Hung Tsai
P2860cites workA NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1Q24338768
p27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapyQ24650994
p27 and BCL2 expression predicts response to chemotherapy in head and neck squamous cell carcinomasQ27852664
Loss of nuclear p27 expression and its prognostic role in relation to cyclin E and p53 mutation in gastroenteropancreatic neuroendocrine tumorsQ33384573
Subcellular localization of p27 and prostate cancer recurrence: automated digital microscopy analysis of tissue microarraysQ33811487
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localizationQ34150579
Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancerQ34436736
p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.Q34472383
Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma.Q34536470
Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanomaQ34696287
cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinomaQ35161430
The prognostic value of altered eIF3a and its association with p27 in non-small cell lung cancersQ35161905
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Q37865381
High p27 expression is associated with a better prognosis in East Asian non-small cell lung cancer patientsQ37924009
Phosphorylation of paxillin confers cisplatin resistance in non-small cell lung cancer via activating ERK-mediated Bcl-2 expressionQ39085744
LKB1 loss by alteration of the NKX2-1/p53 pathway promotes tumor malignancy and predicts poor survival and relapse in lung adenocarcinomasQ39101598
ERK-dependent MKP-1-mediated cisplatin resistance in human ovarian cancer cellsQ40033516
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrestQ40702262
Dual effects of Ral-activated pathways on p27 localization and TGF-β signalingQ41206555
Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signalingQ42196968
p27Kip1 is a predictive factor for tamoxifen treatment response but not a prognostic marker in premenopausal breast cancer patientsQ42748882
cIAP2 Upregulated by E6 Oncoprotein via Epidermal Growth Factor Receptor/Phosphatidylinositol 3-Kinase/AKT Pathway Confers Resistance to Cisplatin in Human Papillomavirus 16/18–Infected Lung CancerQ43777713
Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitroQ48287164
Prognostic significance of cytoplasmic p27 expression in human melanoma.Q53112792
Subcellular Localization and Protein Levels of Cyclin-Dependent Kinase Inhibitor p27 Independently Predict for Survival in Epithelial Ovarian CancerQ57904929
Association between the nuclear to cytoplasmic ratio of p27 and the efficacy of adjuvant polychemotherapy in early breast cancerQ59312907
Formation of p27-CDK complexes during the human mitotic cell cycleQ71569498
High cyclin E and low p27/Kip1 expressions are potentially poor prognostic factors in lung adenocarcinoma patientsQ74513431
Reduced expression of cell-cycle regulator p27(Kip1) correlates with a shortened survival in non-small cell lung cancerQ74513452
Loss of P27Kip1 expression correlates with tumor grade and with reduced disease-free survival in primary superficial bladder cancersQ77973231
Regulation of p27 by S-phase kinase-associated protein 2 is associated with aggressiveness in non-small-cell lung cancerQ80859255
P433issue3
P304page(s)4017-4023
P577publication date2015-10-20
P1433published inTumor BiologyQ15757842
P1476titleAssociation of cytoplasmic p27 expression with an unfavorable response to cisplatin-based chemotherapy and poor outcomes in non-small cell lung cancer
P478volume37