Chimeric West Nile/dengue virus vaccine candidate: preclinical evaluation in mice, geese and monkeys for safety and immunogenicity.

scientific article

Chimeric West Nile/dengue virus vaccine candidate: preclinical evaluation in mice, geese and monkeys for safety and immunogenicity. is …
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scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2006.06.008
P698PubMed publication ID16831498
P5875ResearchGate publication ID6953184

P50authorBrian R. MurphyQ65658906
David SwayneQ67293866
P2093author name stringAlexander G Pletnev
Alexander A Rumyantsev
Jim Speicher
P2860cites workEpitope determinants of a chimpanzee Fab antibody that efficiently cross-neutralizes dengue type 1 and type 2 viruses map to inside and in close proximity to fusion loop of the dengue type 2 virus envelope glycoproteinQ37596501
Comparison of live and inactivated tick-borne encephalitis virus vaccines for safety, immunogenicity and efficacy in rhesus monkeysQ40500583
Infectivity of West Nile/dengue chimeric viruses for West Nile and dengue mosquito vectorsQ40511346
rDEN4delta30, a live attenuated dengue virus type 4 vaccine candidate, is safe, immunogenic, and highly infectious in healthy adult volunteersQ40515729
Molecularly engineered live-attenuated chimeric West Nile/dengue virus vaccines protect rhesus monkeys from West Nile virusQ40549292
Mutations which enhance the replication of dengue virus type 4 and an antigenic chimeric dengue virus type 2/4 vaccine candidate in Vero cellsQ40549813
Genetic basis of attenuation of dengue virus type 4 small plaque mutants with restricted replication in suckling mice and in SCID mice transplanted with human liver cellsQ40575878
Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3'-untranslated region.Q40593118
Loss of active neuroinvasiveness in attenuated strains of West Nile virus: pathogenicity in immunocompetent and SCID miceQ40707919
The Fc portion of antibody to yellow fever virus NS1 is a determinant of protection against YF encephalitis in miceQ40722416
Infectious cDNA clone of attenuated Langat tick-borne flavivirus (strain E5) and a 3' deletion mutant constructed from it exhibit decreased neuroinvasiveness in immunodeficient miceQ40814578
West Nile virusQ64127859
Localization and Characterization of Flavivirus Envelope Glycoprotein Cross-Reactive EpitopesQ24289053
Epidemiology and transmission dynamics of West Nile virus diseaseQ24603195
Recombinant, live-attenuated tetravalent dengue virus vaccine formulations induce a balanced, broad, and protective neutralizing antibody response against each of the four serotypes in rhesus monkeysQ27469474
Chimeric Dengue 2 PDK-53/West Nile NY99 Viruses Retain the Phenotypic Attenuation Markers of the Candidate PDK-53 Vaccine Virus and Protect Mice against Lethal Challenge with West Nile VirusQ27469831
Chemical mutagenesis of dengue virus type 4 yields mutant viruses which are temperature sensitive in vero cells or human liver cells and attenuated in miceQ27469872
Tick-Borne Langat/Mosquito-Borne Dengue Flavivirus Chimera, a Candidate Live Attenuated Vaccine for Protection against Disease Caused by Members of the Tick-Borne Encephalitis Virus Complex: Evaluation in Rhesus Monkeys and in MosquitoesQ27469955
West Nile virus/dengue type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacyQ27471660
Antibodies against West Nile Virus Nonstructural Protein NS1 Prevent Lethal Infection through Fc   Receptor-Dependent and -Independent MechanismsQ27472823
A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient miceQ27472824
A Live, Attenuated Dengue Virus Type 1 Vaccine Candidate with a 30-Nucleotide Deletion in the 3' Untranslated Region Is Highly Attenuated and Immunogenic in MonkeysQ27473080
Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4Q27480832
Fatal Encephalitis and Myocarditis in Young Domestic Geese (Anser anser domesticus) Caused by West Nile VirusQ27487812
West Nile virus vaccinesQ34335105
ChimeriVax-West Nile virus live-attenuated vaccine: preclinical evaluation of safety, immunogenicity, and efficacyQ34362322
West Nile virus: epidemiology and ecology in North AmericaQ35625021
Recent advances in the molecular biology of west nile virusQ36352339
Differences in replication of attenuated and neurovirulent polioviruses in human neuroblastoma cell line SH-SY5Y.Q36827663
P433issue40-41
P407language of work or nameEnglishQ1860
P921main subjectvaccineQ134808
West Nile virusQ158856
Dengue virusQ476209
P1104number of pages13
P304page(s)6392-6404
P577publication date2006-06-21
P1433published inVaccineQ7907941
P1476titleChimeric West Nile/dengue virus vaccine candidate: preclinical evaluation in mice, geese and monkeys for safety and immunogenicity
P478volume24

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cites work (P2860)
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Q27487992A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells
Q34225723A recombinant chimeric La Crosse virus expressing the surface glycoproteins of Jamestown Canyon virus is immunogenic and protective against challenge with either parental virus in mice or monkeys.
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