A Live, Attenuated Dengue Virus Type 1 Vaccine Candidate with a 30-Nucleotide Deletion in the 3' Untranslated Region Is Highly Attenuated and Immunogenic in Monkeys

scientific article (publication date: 2003)

A Live, Attenuated Dengue Virus Type 1 Vaccine Candidate with a 30-Nucleotide Deletion in the 3' Untranslated Region Is Highly Attenuated and Immunogenic in Monkeys is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.77.2.1653-1657.2003
P8608Fatcat IDrelease_cxzm7ffncbhmvgzzyr4rzyp3la
P3181OpenCitations bibliographic resource ID4470355
P932PMC publication ID140839
P698PubMed publication ID12502885

P50authorKathryn A. HanleyQ24809595
Stephen S WhiteheadQ64866574
Brian R. MurphyQ65658906
P2093author name stringBarry Falgout
Lewis Markoff
Joseph E Blaney Jr
P2860cites workIdentification of specific nucleotide sequences within the conserved 3'-SL in the dengue type 2 virus genome required for replicationQ24523550
Attenuation markers of a candidate dengue type 2 vaccine virus, strain 16681 (PDK-53), are defined by mutations in the 5' noncoding region and nonstructural proteins 1 and 3Q27469644
Chimeric dengue type 2 (vaccine strain PDK-53)/dengue type 1 virus as a potential candidate dengue type 1 virus vaccineQ27469646
Construction, safety, and immunogenicity in nonhuman primates of a chimeric yellow fever-dengue virus tetravalent vaccineQ27469921
Derivation and characterization of a dengue type 1 host range-restricted mutant virus that is attenuated and highly immunogenic in monkeysQ27472847
Secondary structure of the 3'-noncoding region of flavivirus genomes: comparative analysis of base pairing probabilitiesQ27472948
Secondary structure of the 3' untranslated region of flaviviruses: similarities and differencesQ27473202
Dengue type 4 virus mutants containing deletions in the 3' noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeysQ27480386
Infectious RNA transcripts from full-length dengue virus type 2 cDNA clones made in yeastQ27480837
Widespread intra-serotype recombination in natural populations of dengue virusQ27485173
Conserved elements in the 3' untranslated region of flavivirus RNAs and potential cyclization sequencesQ29620940
Development of a novel mouse model for dengue virus infectionQ33330448
Impact of dengue/dengue hemorrhagic fever on the developing worldQ33784757
Natural genetic exchanges between vaccine and wild poliovirus strains in humans.Q39612254
Genetic basis of attenuation of dengue virus type 4 small plaque mutants with restricted replication in suckling mice and in SCID mice transplanted with human liver cellsQ40575878
A live attenuated recombinant dengue-4 virus vaccine candidate with restricted capacity for dissemination in mosquitoes and lack of transmission from vaccinees to mosquitoes.Q40593111
Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3'-untranslated region.Q40593118
Construction of a full length infectious clone for dengue-1 virus Western Pacific,74 strainQ40623323
Molecular analysis of dengue virus attenuation after serial passage in primary dog kidney cellsQ40646524
The 3'-nucleotides of flavivirus genomic RNA form a conserved secondary structureQ40806302
Comparative susceptibility of five species of Toxorhynchites mosquitoes to parenteral infection with dengue and other flavivirusesQ40817124
Comparative susceptibility of mosquito species and strains to oral and parenteral infection with dengue and Japanese encephalitis viruses.Q40818653
P433issue2
P921main subjectvaccineQ134808
Dengue virusQ476209
attenuated vaccineQ1810913
P304page(s)1653-7
P577publication date2003-01-01
P1433published inJournal of VirologyQ1251128
P1476titleA Live, Attenuated Dengue Virus Type 1 Vaccine Candidate with a 30-Nucleotide Deletion in the 3' Untranslated Region Is Highly Attenuated and Immunogenic in Monkeys
P478volume77

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