Dengue virus type 3 vaccine candidates generated by introduction of deletions in the 3′ untranslated region (3′-UTR) or by exchange of the DENV-3 3′-UTR with that of DENV-4

scientific article (publication date: 6 February 2008)

Dengue virus type 3 vaccine candidates generated by introduction of deletions in the 3′ untranslated region (3′-UTR) or by exchange of the DENV-3 3′-UTR with that of DENV-4 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.VACCINE.2007.11.082
P932PMC publication ID2246307
P698PubMed publication ID18191005
P5875ResearchGate publication ID5660523

P50authorKathryn A. HanleyQ24809595
Joseph E BlaneyQ112131210
Christopher T HansonQ115158009
Stephen S WhiteheadQ64866574
Brian R. MurphyQ65658906
P2093author name stringTammy A Romero
Neeraj S Sathe
Laura Goddard
P2860cites workMfold web server for nucleic acid folding and hybridization predictionQ24498105
Identification of specific nucleotide sequences within the conserved 3'-SL in the dengue type 2 virus genome required for replicationQ24523550
Dengue and dengue hemorrhagic feverQ24550739
Vaccine candidates derived from a novel infectious cDNA clone of an American genotype dengue virus type 2Q24805308
Recombinant, live-attenuated tetravalent dengue virus vaccine formulations induce a balanced, broad, and protective neutralizing antibody response against each of the four serotypes in rhesus monkeysQ27469474
Derivation and characterization of a dengue type 1 host range-restricted mutant virus that is attenuated and highly immunogenic in monkeysQ27472847
Sequence comparison and secondary structure analysis of the 3' noncoding region of flavivirus genomes reveals multiple pseudoknots.Q27472958
A Live, Attenuated Dengue Virus Type 1 Vaccine Candidate with a 30-Nucleotide Deletion in the 3' Untranslated Region Is Highly Attenuated and Immunogenic in MonkeysQ27473080
Secondary structure of the 3' untranslated region of flaviviruses: similarities and differencesQ27473202
Dengue type 4 virus mutants containing deletions in the 3' noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeysQ27480386
Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue virusesQ27860800
Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structureQ27860806
Prospects for a dengue virus vaccineQ29619608
The global pandemic of dengue/dengue haemorrhagic fever: current status and prospects for the futureQ30430980
Genetically modified, live attenuated dengue virus type 3 vaccine candidatesQ31140519
Safety and immunogenicity of attenuated dengue virus vaccines (Aventis Pasteur) in human volunteersQ33336929
Impact of dengue/dengue hemorrhagic fever on the developing worldQ33784757
5'- and 3'-noncoding regions in flavivirus RNA.Q35616820
Development of a live attenuated dengue virus vaccine using reverse geneticsQ36428460
Epidemic Dengue 3 in Central Java, Associated with Low Viremia in Man *Q36659267
Safety and immunogenicity of tetravalent live-attenuated dengue vaccines in Thai adult volunteers: role of serotype concentration, ratio, and multiple doses.Q39417682
Genetic variation in the 3' non-coding region of dengue viruses.Q39460462
Secondary structure of dengue virus type 4 3' untranslated region: impact of deletion and substitution mutationsQ40222010
Rational design of genetically stable, live-attenuated poliovirus vaccines of all three serotypes: relevance to poliomyelitis eradicationQ40243124
Immunogenicity and safety of two live-attenuated tetravalent dengue vaccine formulations in healthy Australian adults.Q40382643
Role of RNA structures present at the 3'UTR of dengue virus on translation, RNA synthesis, and viral replicationQ40400756
rDEN2/4Delta30(ME), a live attenuated chimeric dengue serotype 2 vaccine is safe and highly immunogenic in healthy dengue-naïve adults.Q40464785
The live attenuated dengue serotype 1 vaccine rDEN1Delta30 is safe and highly immunogenic in healthy adult volunteers.Q40468552
rDEN4delta30, a live attenuated dengue virus type 4 vaccine candidate, is safe, immunogenic, and highly infectious in healthy adult volunteersQ40515729
Introduction of mutations into the non-structural genes or 3' untranslated region of an attenuated dengue virus type 4 vaccine candidate further decreases replication in rhesus monkeys while retaining protective immunityQ40528042
Phase I trial of 16 formulations of a tetravalent live-attenuated dengue vaccineQ40536052
Vaccination of human volunteers with monovalent and tetravalent live-attenuated dengue vaccine candidatesQ40541513
Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice, and rhesus monkeysQ40549819
A trade-off in replication in mosquito versus mammalian systems conferred by a point mutation in the NS4B protein of dengue virus type 4.Q40553373
Genetic basis of attenuation of dengue virus type 4 small plaque mutants with restricted replication in suckling mice and in SCID mice transplanted with human liver cellsQ40575878
A live attenuated recombinant dengue-4 virus vaccine candidate with restricted capacity for dissemination in mosquitoes and lack of transmission from vaccinees to mosquitoes.Q40593111
Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3'-untranslated region.Q40593118
Recombination and flavivirus vaccines: a commentaryQ42991651
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectDengue virusQ476209
vaccineQ134808
DENV-3Q106250534
DENV-4Q106411493
P304page(s)817-28
P577publication date2008-02-06
P1433published inVaccineQ7907941
P1476titleDengue virus type 3 vaccine candidates generated by introduction of deletions in the 3′ untranslated region (3′-UTR) or by exchange of the DENV-3 3′-UTR with that of DENV-4
P478volume26

Reverse relations

cites work (P2860)
Q59358841A Single Mutation at Position 156 in the Envelope Protein of Tembusu Virus Is Responsible for Virus Tissue Tropism and Transmissibility in Ducks
Q28741828A novel single-dose dengue subunit vaccine induces memory immune responses
Q33919503A single amino acid in nonstructural protein NS4B confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis
Q33988937A single dose of the DENV-1 candidate vaccine rDEN1Δ30 is strongly immunogenic and induces resistance to a second dose in a randomized trial
Q35272502An adjuvanted, tetravalent dengue virus purified inactivated vaccine candidate induces long-lasting and protective antibody responses against dengue challenge in rhesus macaques
Q97521587Anti-dengue Vaccines: From Development to Clinical Trials
Q64883121Beyond Neutralizing Antibody Levels: The Epitope Specificity of Antibodies Induced by National Institutes of Health Monovalent Dengue Virus Vaccines.
Q33839001Bioinformatics in new generation flavivirus vaccines
Q35180143Capsid protein: evidences about the partial protective role of neutralizing antibody-independent immunity against dengue in monkeys
Q38140035Challenges in reducing dengue burden; diagnostics, control measures and vaccines
Q38605190Clinical evaluation strategies for a live attenuated tetravalent dengue vaccine.
Q40239548Comparison of full-length genomics sequences between dengue virus serotype 3, parental strain, and its derivatives, and B-cell epitopes prediction from envelope region
Q57059015Decreased accumulation of subgenomic RNA in human cells infected with vaccine candidate DEN4Δ30 increases viral susceptibility to type I interferon
Q91711499Defeat Dengue and Zika Viruses With a One-Two Punch of Vaccine and Vector Blockade
Q34184711Development and characterization of a reverse genetic system for studying dengue virus serotype 3 strain variation and neutralization
Q35206695Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccine
Q24289057Ecuador Paraiso Escondido Virus, a New Flavivirus Isolated from New World Sand Flies in Ecuador, Is the First Representative of a Novel Clade in the Genus Flavivirus
Q26825663Endothelial cells in dengue hemorrhagic fever
Q56794148Epitope Sequences in Dengue Virus NS1 Protein Identified by Monoclonal Antibodies
Q39118535Expression of dengue-3 premembrane and envelope polyprotein in lettuce chloroplasts
Q26864533Fever versus fever: the role of host and vector susceptibility and interspecific competition in shaping the current and future distributions of the sylvatic cycles of dengue virus and yellow fever virus
Q34432758Flaviviral RNAs: weapons and targets in the war between virus and host
Q38289956Flavivirus reverse genetic systems, construction techniques and applications: a historical perspective
Q26700111Functions of the 3' and 5' genome RNA regions of members of the genus Flavivirus
Q27486407Identification of Mutated Cyclization Sequences That Permit Efficient Replication of West Nile Virus Genomes: Use in Safer Propagation of a Novel Vaccine Candidate
Q30395396Issues related to recent dengue vaccine development
Q28657429Molecular archaeology of Flaviviridae untranslated regions: duplicated RNA structures in the replication enhancer of flaviviruses and pestiviruses emerged via convergent evolution
Q42630075New reverse genetics and transfection methods to rescue arboviruses in mosquito cells
Q56795718Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines
Q27490989Phase 1 Trial of the Dengue Virus Type 4 Vaccine Candidate rDEN4 30-4995 in Healthy Adult Volunteers
Q28595165Possible Roles of New Mutations Shared by Asian and American Zika Viruses
Q35009119Progress towards a dengue vaccine
Q34675614RNA Structure Duplications and Flavivirus Host Adaptation
Q38303232Recent progress in dengue vaccine development
Q35070580Repertoire of virus-derived small RNAs produced by mosquito and mammalian cells in response to dengue virus infection
Q42026897Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus.
Q91728039Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques
Q27487528Structural and Functional Studies of the Promoter Element for Dengue Virus RNA Replication
Q34070463Substitution of NS5 N-terminal domain of dengue virus type 2 RNA with type 4 domain caused impaired replication and emergence of adaptive mutants with enhanced fitness
Q36118259Targeted mutagenesis as a rational approach to dengue virus vaccine development
Q32183359The 5' and 3' Untranslated Regions of the Flaviviral Genome
Q37324444The live attenuated chimeric vaccine rWN/DEN4Δ30 is well-tolerated and immunogenic in healthy flavivirus-naïve adult volunteers
Q37350360Third-generation flavivirus vaccines based on single-cycle, encapsidation-defective viruses
Q27011587Understanding the dengue viruses and progress towards their control
Q34238916Utility, limitations, and future of non-human primates for dengue research and vaccine development
Q37184768Vaccination of volunteers with low-dose, live-attenuated, dengue viruses leads to serotype-specific immunologic and virologic profiles
Q30376550Vero cell platform in vaccine production: moving towards cell culture-based viral vaccines.
Q53165070WHO Working Group on technical specifications for manufacture and evaluation of dengue vaccines, Geneva, Switzerland, 11-12 May 2009.
Q57168259What Does the Future Hold for Yellow Fever Virus? (II)
Q47178548Zika Virus Exhibits Lineage-Specific Phenotypes in Cell Culture, in Aedes aegypti Mosquitoes, and in an Embryo Model

Search more.