Phase 1 Trial of the Dengue Virus Type 4 Vaccine Candidate rDEN4 30-4995 in Healthy Adult Volunteers

scientific article (publication date: November 2009)

Phase 1 Trial of the Dengue Virus Type 4 Vaccine Candidate rDEN4 30-4995 in Healthy Adult Volunteers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4269/AJTMH.2009.09-0131
P3181OpenCitations bibliographic resource ID3191727
P932PMC publication ID2829759
P698PubMed publication ID19861619
P5875ResearchGate publication ID38040824

P50authorStephen S WhiteheadQ64866574
Brian R. MurphyQ65658906
Anna DurbinQ87882927
Joseph E BlaneyQ112131210
Bhavin ThumarQ115158021
P2093author name stringMichael T Rock
Brett A McKinney
Alexander C Schmidt
Peter F Wright
Susan Henderson
Mine R Ikizler
Sharon Ankrah
P2860cites workImmunogenicity and safety of two live-attenuated tetravalent dengue vaccine formulations in healthy Australian adults.Q40382643
Dengue and yellow fever--challenges for the development and use of vaccinesQ40433390
rDEN2/4Delta30(ME), a live attenuated chimeric dengue serotype 2 vaccine is safe and highly immunogenic in healthy dengue-naïve adults.Q40464785
The live attenuated dengue serotype 1 vaccine rDEN1Delta30 is safe and highly immunogenic in healthy adult volunteers.Q40468552
Live attenuated chimeric yellow fever dengue type 2 (ChimeriVax-DEN2) vaccine: Phase I clinical trial for safety and immunogenicity: effect of yellow fever pre-immunity in induction of cross neutralizing antibody responses to all 4 dengue serotypes.Q40468558
rDEN4delta30, a live attenuated dengue virus type 4 vaccine candidate, is safe, immunogenic, and highly infectious in healthy adult volunteersQ40515729
Introduction of mutations into the non-structural genes or 3' untranslated region of an attenuated dengue virus type 4 vaccine candidate further decreases replication in rhesus monkeys while retaining protective immunityQ40528042
Phase I trial of 16 formulations of a tetravalent live-attenuated dengue vaccineQ40536052
Vaccination of human volunteers with monovalent and tetravalent live-attenuated dengue vaccine candidatesQ40541513
Genetic basis of attenuation of dengue virus type 4 small plaque mutants with restricted replication in suckling mice and in SCID mice transplanted with human liver cellsQ40575878
A live attenuated recombinant dengue-4 virus vaccine candidate with restricted capacity for dissemination in mosquitoes and lack of transmission from vaccinees to mosquitoes.Q40593111
Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3'-untranslated region.Q40593118
Testing of a dengue 2 live-attenuated vaccine (strain 16681 PDK 53) in ten American volunteersQ40671401
A live attenuated dengue-1 vaccine candidate (45AZ5) passaged in primary dog kidney cell culture is attenuated and immunogenic for humansQ40693060
Liver biochemical tests and dengue feverQ40730168
Infections with two dengue viruses in Greece in the 20th century. Did dengue hemorrhagic fever occur in the 1928 epidemic?Q40782627
Virulence of a live dengue virus vaccine candidate: a possible new marker of dengue virus attenuationQ40782907
Selection of attenuated dengue 4 viruses by serial passage in primary kidney cells. V. Human response to immunization with a candidate vaccine prepared in fetal rhesus lung cellsQ40826105
Dengue virus type 2 vaccine: reactogenicity and immunogenicity in soldiersQ40826955
Serological studies on volunteers inoculated experimentally with a dengue virus strain in 1943.Q40831812
Epidemiologic, clinical, and virologic observations on dengue in the Kingdom of TongaQ40875766
Measuring the burden of neglected tropical diseases: the global burden of disease frameworkQ21144557
Chemical mutagenesis of dengue virus type 4 yields mutant viruses which are temperature sensitive in vero cells or human liver cells and attenuated in miceQ27469872
Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypesQ27472938
Dengue virus type 3 vaccine candidates generated by introduction of deletions in the 3′ untranslated region (3′-UTR) or by exchange of the DENV-3 3′-UTR with that of DENV-4Q27485404
Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severityQ27486434
Phase I clinical evaluation of rDEN4Delta30-200,201: a live attenuated dengue 4 vaccine candidate designed for decreased hepatotoxicityQ27487377
Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severityQ27860703
A prospective study of dengue infections in BangkokQ28296365
Research on dengue during World War IIQ29619423
Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreakQ29619424
Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic feverQ29619530
Prospects for a dengue virus vaccineQ29619608
Global spread and persistence of dengueQ29619711
A prospective seroepidemiologic study on dengue in children four to nine years of age in Yogyakarta, Indonesia I. studies in 1995-1996.Q30778819
Safety and immunogenicity of attenuated dengue virus vaccines (Aventis Pasteur) in human volunteersQ33336929
Epidemiology, clinical features, laboratory investigations and early diagnosis of dengue fever in adults: a descriptive study in Sri Lanka.Q33368100
Antibody to dengue 1 detected more than 60 years after infectionQ34883085
Cytokine expression patterns associated with systemic adverse events following smallpox immunizationQ35106139
Development of a live attenuated dengue virus vaccine using reverse geneticsQ36428460
Safety and efficacy of chimeric yellow Fever-dengue virus tetravalent vaccine formulations in nonhuman primatesQ37423499
Safety and immunogenicity of tetravalent live-attenuated dengue vaccines in Thai adult volunteers: role of serotype concentration, ratio, and multiple doses.Q39417682
Phase 2 clinical trial of three formulations of tetravalent live-attenuated dengue vaccine in flavivirus-naïve adultsQ39955421
MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cellsQ40209351
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectpharmacologyQ128406
Dengue virusQ476209
phase I clinical trialQ5452194
P304page(s)834-41
P577publication date2009-11-01
P1433published inAmerican Journal of Tropical Medicine and HygieneQ15766943
P1476titlePhase 1 Trial of the Dengue Virus Type 4 Vaccine Candidate rDEN4 30-4995 in Healthy Adult Volunteers
P478volume81

Reverse relations

cites work (P2860)
Q37812291A molecular evaluation of dengue virus pathogenesis and its latest vaccine strategies
Q27680467Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus
Q34367194Dengue vaccines: recent developments, ongoing challenges and current candidates
Q28298464Dengue: a continuing global threat
Q35206695Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccine
Q40342385Evaluation of a prototype dengue-1 DNA vaccine in a Phase 1 clinical trial
Q39118535Expression of dengue-3 premembrane and envelope polyprotein in lettuce chloroplasts
Q66679185In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment
Q30395396Issues related to recent dengue vaccine development
Q38221220Natural products as source of potential dengue antivirals
Q37904025Next generation dengue vaccines: a review of candidates in preclinical development
Q30400192Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses.
Q38303232Recent progress in dengue vaccine development
Q36181531Robust and Balanced Immune Responses to All 4 Dengue Virus Serotypes Following Administration of a Single Dose of a Live Attenuated Tetravalent Dengue Vaccine to Healthy, Flavivirus-Naive Adults
Q36288109Safety and immunogenicity of a recombinant live attenuated tetravalent dengue vaccine (DENVax) in flavivirus-naive healthy adults in Colombia: a randomised, placebo-controlled, phase 1 study
Q34707858Serologic imprint of dengue virus in urban Haiti: characterization of humoral immunity to dengue in infants and young children
Q26314683The dengue vaccine pipeline: Implications for the future of dengue control
Q42710655The necessity and quandaries of dengue vaccine development
Q28074355Trends in clinical trials of dengue vaccine
Q37184768Vaccination of volunteers with low-dose, live-attenuated, dengue viruses leads to serotype-specific immunologic and virologic profiles
Q34630584Will dengue vaccines be used in the public sector and if so, how? Findings from an 8-country survey of policymakers and opinion leaders