Glutamate carboxypeptidase II is not an amyloid peptide-degrading enzyme.

scientific article

Glutamate carboxypeptidase II is not an amyloid peptide-degrading enzyme. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1096/FJ.12-225102
P932PMC publication ID4050421
P698PubMed publication ID23525278
P5875ResearchGate publication ID236077177

P50authorBarbara S SlusherQ63959262
Camilo RojasQ88917692
Marigo StathisQ124367003
Jesse AltQ124367018
P2860cites workStructure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancerQ24542039
Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methodsQ27654221
N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous systemQ28141091
Kinetics and inhibition of glutamate carboxypeptidase II using a microplate assayQ28212824
Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic painQ28216278
The preventive and therapeutic effects of GCPII (NAALADase) inhibition on painful and sensory diabetic neuropathyQ28246650
The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophreniaQ28264674
Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis modelsQ28572282
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspectiveQ29614702
Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidaseQ33576278
Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanismQ33601673
The role of excitotoxicity in neurodegenerative disease: implications for therapyQ33639170
Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats.Q33641563
Beyond the role of glutamate as a neurotransmitterQ34810158
Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancerQ35645376
The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693.Q35827155
Glutamate carboxypeptidase II in diagnosis and treatment of neurologic disorders and prostate cancerQ37972920
Glutamate carboxypeptidase II: an overview of structural studies and their importance for structure-based drug design and deciphering the reaction mechanism of the enzymeQ37981284
GCPII variants, paralogs and orthologs.Q37981286
Structure-activity relationships of glutamate carboxypeptidase II (GCPII) inhibitorsQ37981291
Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain modelQ40539364
Glutamate carboxypeptidase II: an amyloid peptide-degrading enzyme with physiological function in the brainQ42972458
Glutamate carboxypeptidase inhibition reduces the severity of chemotherapy-induced peripheral neurotoxicity in rat.Q43274870
Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II.Q43924725
NAALADase (GCP II) inhibition prevents cocaine-kindled seizuresQ44146749
Effects of GCP-II inhibition on responses of dorsal horn neurones after inflammation and neuropathy: an electrophysiological study in the rat.Q44648418
Inhibition of glutamate carboxypeptidase II (NAALADase) protects against dynorphin A-induced ischemic spinal cord injury in ratsQ45243986
NAAG peptidase inhibitor reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion TBI in ratsQ45270189
Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.Q46441061
Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain.Q48193288
Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterizationQ48838190
Competitive inhibition of N-acetylated-alpha-linked acidic dipeptidase activity by N-acetyl-L-aspartyl-beta-linked L-glutamateQ48940210
Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolismQ71530371
Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous systemQ73129289
Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injuryQ73226156
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cellsQ73456893
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)2620-2625
P577publication date2013-03-23
P1433published inFASEB JournalQ520194
P1476titleGlutamate carboxypeptidase II is not an amyloid peptide-degrading enzyme.
P478volume27