Cleavage of Notch1 by granzyme B disables its transcriptional activity.

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Cleavage of Notch1 by granzyme B disables its transcriptional activity. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ20110226
P932PMC publication ID4050498
P698PubMed publication ID21548883

P50authorPaul J van DiestQ85899264
P2093author name stringJan Meeldijk
Marc Vooijs
Niels Bovenschen
Geert van Tetering
P2860cites workNotch inhibits apoptosis by direct interference with XIAP ubiquitination and degradationQ24298097
Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membraneQ24321237
Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteinsQ24324093
Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysmQ24645335
The Notch1 receptor is cleaved constitutively by a furin-like convertaseQ24671866
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complexQ24675233
Structural basis for autoinhibition of NotchQ27644319
Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme MQ27656093
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domainQ28141707
The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T CellsQ28212977
Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivoQ28266759
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domainQ28273268
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)Q28286560
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemiaQ29614269
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosisQ29617776
Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosisQ33247896
Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.Q33965862
Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathwayQ34063426
Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B.Q34120058
Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.Q34501252
Death by a thousand cuts: granzyme pathways of programmed cell deathQ34588821
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.Q35000965
Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathwayQ35020680
Notch regulates cytolytic effector function in CD8+ T cells.Q35219642
Extracellular granzymes: current perspectivesQ36567777
The different faces of Notch in T-helper-cell differentiationQ37376021
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.Q37724159
Orphan granzymes find a homeQ37763995
Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular regionQ39725752
Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells.Q39843637
Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement.Q39905527
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classesQ40273258
Cell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast Pichia pastorisQ40342409
Ligand-induced signaling in the absence of furin processing of Notch1.Q40833238
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives.Q41078359
Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.Q42981625
Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A.Q46211971
NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule networkQ46560058
lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H).Q47069543
The suppressor of hairless protein participates in notch receptor signalingQ47072502
Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells.Q53631737
Osmotic swelling of phospholipid vesicles causes them to fuse with a planar phospholipid bilayer membraneQ72934239
Nuclear translocation of granzyme B in target cell apoptosisQ73540343
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1Q73958442
The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)Q77774922
Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cellsQ80092770
Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regressionQ81066571
Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53Q83228672
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)313-322
P577publication date2011-07-01
P1433published inBiochemical JournalQ864221
P1476titleCleavage of Notch1 by granzyme B disables its transcriptional activity.
P478volume437

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cites work (P2860)
Q37103319High NOTCH activity induces radiation resistance in non small cell lung cancer
Q36779384IL-21-stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation
Q33569831Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.
Q35595880Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6.
Q38993482Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins