Exceptionally potent anti-tumor bystander activity of an scFv:sTRAIL fusion protein with specificity for EGP2 toward target antigen-negative tumor cells

scientific article

Exceptionally potent anti-tumor bystander activity of an scFv:sTRAIL fusion protein with specificity for EGP2 toward target antigen-negative tumor cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1593/NEO.04229
P932PMC publication ID1531668
P698PubMed publication ID15548373
P5875ResearchGate publication ID8179506

P50authorEdwin BremerQ39507482
P2093author name stringBart-Jan Kroesen
Wijnand Helfrich
Linda van Genne
Douwe Samplonius
Lou de Leij
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Clinically distinct subgroups of glioblastoma multiforme studied by comparative genomic hybridization.Q38479371
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The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.Q41517544
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Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft modelsQ43931271
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Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk geneQ44371834
Target cell-restricted and -enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma-associated antigen EGP2.Q51829884
Phenotypic transformation of CD52(pos) to CD52(neg) leukemic T cells as a mechanism for resistance to CAMPATH-1H.Q53972232
Radioiodinated (I-125) monoclonal antibody 425 in the treatment of high grade glioma patients: ten-year synopsis of a novel treatment.Q55473118
Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.Q55476497
Biological and molecular analysis of a low-grade recurrence of a glioblastoma multiforme.Q55479942
Cytogenetic and flow cytometry DNA analysis of regional heterogeneity in a low grade human glioma.Q55480905
Adenovirus-TRAIL can overcome TRAIL resistance and induce a bystander effectQ64377565
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Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosisQ73596247
The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activationQ73783868
The epithelial glycoprotein 2 (EGP-2) promoter-driven epithelial-specific expression of EGP-2 in transgenic mice: a new model to study carcinoma-directed immunotherapyQ73893996
Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivativeQ74332891
Intratumoral genetic heterogeneity in Barrett adenocarcinomaQ77898310
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)636-645
P577publication date2004-09-01
P1433published inNeoplasiaQ2962042
P1476titleExceptionally potent anti-tumor bystander activity of an scFv:sTRAIL fusion protein with specificity for EGP2 toward target antigen-negative tumor cells
P478volume6

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