In Vivo Gene Delivery to Lymph Node Stromal Cells Leads to Transgene-specific CD8+ T Cell Anergy in Mice.

scientific article published on 26 August 2016

In Vivo Gene Delivery to Lymph Node Stromal Cells Leads to Transgene-specific CD8+ T Cell Anergy in Mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/MT.2016.168
P932PMC publication ID5154481
P698PubMed publication ID27562586

P50authorSéverine CiréQ84241154
P2093author name stringAnne Galy
Mary K Collins
Sylvie Da Rocha
Maxime Ferrand
P2860cites workModes of Antigen Presentation by Lymph Node Stromal Cells and Their Immunological ImplicationsQ26781338
Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-PresentationQ26801963
Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentationQ30434547
Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell toleranceQ30579730
Single-chain antibodies that target lentiviral vectors to MHC class II on antigen-presenting cells.Q33414813
Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditionsQ33794995
Immunization of mice with lentiviral vectors targeted to MHC class II+ cells is due to preferential transduction of dendritic cells in vivoQ33945680
Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity.Q34320316
Acquisition and presentation of follicular dendritic cell-bound antigen by lymph node-resident dendritic cellsQ34501458
Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transferQ34516810
DARPins: an efficient targeting domain for lentiviral vectorsQ34757199
A dystrophic muscle broadens the contribution and activation of immune cells reacting to rAAV gene transferQ34814931
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic riskQ35038004
A novel bacterial artificial chromosome-transgenic podoplanin-cre mouse targets lymphoid organ stromal cells in vivoQ35927784
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarksQ36007057
MyD88 signaling in B cells regulates the production of Th1-dependent antibodies to AAVQ36142477
In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic toleranceQ37472002
Exploiting and antagonizing microRNA regulation for therapeutic and experimental applicationsQ37553909
Targeted cell entry of lentiviral vectorsQ37589994
Immunogenicity of targeted lentivectors.Q37718447
Thymic epithelial cells: working class heroes for T cell development and repertoire selectionQ38010575
Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene DeliveryQ38615314
Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transferQ39302902
Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation.Q42095379
A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A.Q42709633
Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in miceQ43702736
A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B miceQ43919575
Liver-restricted expression of the canine factor VIII gene facilitates prevention of inhibitor formation in factor VIII-deficient mice.Q44045328
Extrathymic induction of Foxp3⁺ regulatory T cells declines with age in a T-cell intrinsic manner.Q45730470
Prolonged gene expression in muscle is achieved without active immune tolerance using microrRNA 142.3p-regulated rAAV gene transfer.Q45737180
Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity.Q54538338
Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal selfQ57232929
Lentiviral vectors targeted to MHC II are effective in immunizationQ83236580
P433issue11
P304page(s)1965-1973
P577publication date2016-08-26
P1433published inMolecular TherapyQ15762400
P1476titleIn Vivo Gene Delivery to Lymph Node Stromal Cells Leads to Transgene-specific CD8+ T Cell Anergy in Mice
P478volume24

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cites work (P2860)
Q59754901Altered Function of Antigen-Presenting Cells in Type 1 Diabetes: A Challenge for Antigen-Specific Immunotherapy?
Q40187007Antigen-presenting cell-targeted lentiviral vectors do not support the development of productive T-cell effector responses: implications for in vivo targeted vaccine delivery.
Q47940254Exploiting lymphatic vessels for immunomodulation: Rationale, opportunities, and challenges.
Q92222884Nanoparticles versus Dendritic Cells as Vehicles to Deliver mRNA Encoding Multiple Epitopes for Immunotherapy
Q90185635Role of lymph node stroma and microenvironment in T cell tolerance
Q37580778Shaping of Peripheral T Cell Responses by Lymphatic Endothelial Cells.

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