Structure-activity relationships in platinum-acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity.

scientific article published on 6 April 2004

Structure-activity relationships in platinum-acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00775-004-0541-4
P698PubMed publication ID15067524
P5875ResearchGate publication ID8633158

P50authorSue Berners-PriceQ68175227
P2093author name stringUlrich Bierbach
Cynthia S Day
Marcus W Wright
Colin G Barry
Michael C Farmer
Suzanne M Hess
Amanda M Mounce
Margaret C Ackley
Beth-Erin Springer
P2860cites workIn vitro studies on the mechanisms of oxaliplatin resistanceQ30786319
Unusual intercalation of acridin-9-ylthiourea into the 5'-GA/TC DNA base step from the minor groove: implications for the covalent DNA adduct profile of a novel platinum-intercalator conjugateQ38352682
Antitumor activity of 13,14-dihydro-15-deoxy-delta7-prostaglandin-A1-methyl ester integrated into lipid microspheres against human ovarian carcinoma cells resistant to cisplatin in vivoQ40933135
Design, synthesis, and biological activity of a novel non-cisplatin-type platinum-acridine pharmacophoreQ43812059
Mechanism of action of non-cisplatin type DNA-targeted platinum anticancer agents: DNA interactions of novel acridinylthioureas and their platinum conjugatesQ44068264
Thermally inert metal ammines as light-inducible DNA-targeted agents. Synthesis, photochemistry, and photobiology of a prototypical rhodium(III)-intercalator conjugateQ44258416
Unprecedented monofunctional metalation of adenine nucleobase in guanine- and thymine-containing dinucleotide sequences by a cytotoxic platinum-acridine hybrid agentQ44540150
Structure, Recognition, and Processing of Cisplatin-DNA Adducts.Q55035583
P433issue4
P921main subjectcytotoxicityQ246181
P304page(s)453-461
P577publication date2004-04-06
P1433published inJournal of Biological Inorganic ChemistryQ3186899
P1476titleStructure-activity relationships in platinum-acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity
P478volume9

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