Characterization of the bisintercalative DNA binding mode of a bifunctional platinum-acridine agent

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Characterization of the bisintercalative DNA binding mode of a bifunctional platinum-acridine agent is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKI869
P932PMC publication ID1236979
P698PubMed publication ID16192574
P5875ResearchGate publication ID7571519

P2093author name stringUlrich Bierbach
Jayati Roy Choudhury
P2860cites workEquilibrium constants for the binding of an homologous series of monofunctional and bifunctional intercalating diacridines to calf thymus DNAQ44534851
Unprecedented monofunctional metalation of adenine nucleobase in guanine- and thymine-containing dinucleotide sequences by a cytotoxic platinum-acridine hybrid agentQ44540150
Design, synthesis, and biological properties of new bis(acridine-4-carboxamides) as anticancer agentsQ44635868
Metal-intercalator-mediated self-association and one-dimensional aggregation in the structure of the excised major DNA adduct of a platinum-acridine agentQ44834538
Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drugQ45022876
Duplex-promoted platination of adenine-N3 in the minor groove of DNA: challenging a longstanding bioinorganic paradigmQ45237706
Solution structural study of a DNA duplex containing the guanine-N7 adduct formed by a cytotoxic platinum-acridine hybrid agentQ46441863
DNA minor groove adducts formed by a platinum-acridine conjugate inhibit association of tata-binding protein with its cognate sequenceQ46651162
Design of a sequence-specific DNA bisintercalatorQ46802972
Sequence-selective intercalation of antitumour bis-naphthalimides into DNA. Evidence for an approach via the major groove.Q50536738
Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring.Q52435495
Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.Q52904158
Improved nearest-neighbor parameters for predicting DNA duplex stabilityQ71099199
TATA element recognition by the TATA box-binding protein has been conserved throughout evolutionQ27620828
Solution structure of a quinomycin bisintercalator-DNA complexQ27730362
Solution structure of a complex between [N-MeCys3,N-MeCys7]TANDEM and [d(GATATC)]2Q27732103
How proteins recognize the TATA boxQ27733301
Unique base-step recognition by a platinum-acridinylthiourea conjugate leads to a DNA damage profile complementary to that of the anticancer drug cisplatinQ31084224
Biophysical characterization and molecular modeling of the coordinative-intercalative DNA monoadduct of a platinum-acridinylthiourea agent in a site-specifically modified dodecamerQ33199658
Hairpin-duplex equilibrium reflected in the A-->B transition in an undecamer quasi-palindrome present in the locus control region of the human beta-globin gene clusterQ33987083
DNA polyintercalating drugs: DNA binding of diacridine derivativesQ35084755
Circular dichroism spectroscopy of DNAQ35402010
Platinum-intercalator conjugates: from DNA-targeted cisplatin derivatives to adenine binding complexes as potential modulators of gene regulationQ35972641
The complexities of eukaryotic transcription initiation: regulation of preinitiation complex assemblyQ36924748
Site selective bis-intercalation of a homodimeric thiazole orange dye in DNA oligonucleotidesQ38297719
DNA unwinding produced by site-specific intrastrand cross-links of the antitumor drug cis-diamminedichloroplatinum(II).Q38333904
Drug--DNA interactions.Q38335482
Unusual intercalation of acridin-9-ylthiourea into the 5'-GA/TC DNA base step from the minor groove: implications for the covalent DNA adduct profile of a novel platinum-intercalator conjugateQ38352682
DNA bifunctional intercalators. 1. Synthesis and conformational properties of an ethidium homodimer and of an acridine ethidium heterodimerQ39225649
Echinomycin: the first bifunctional intercalating agent in clinical trialsQ39839425
Platinum-acridinylthiourea conjugates show cell line-specific cytotoxic enhancement in H460 lung carcinoma cells compared to cisplatinQ40422200
A non-crosslinking platinum-acridine hybrid agent shows enhanced cytotoxicity compared to clinical BCNU and cisplatin in glioblastoma cells.Q40480043
Structure-activity relationships in platinum-acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity.Q40569554
Bisintercalating threading diacridines: relationships between DNA binding, cytotoxicity, and cell cycle arrestQ40608732
Optical absorbance and fluorescence techniques for measuring DNA-drug interactionsQ41667622
Stacking interactions and intercalative DNA bindingQ41756791
Proton exchange in DNA-luzopeptin and DNA-echinomycin bisintercalation complexes: rates and processes of base-pair opening.Q42598667
DNA Bifunctional intercalators. 2. Fluorescence properties and DNA binding interaction of an ethidium homodimer and an acridine ethidium heterodimerQ43649070
Design, synthesis, and biological activity of a novel non-cisplatin-type platinum-acridine pharmacophoreQ43812059
Mechanism of action of non-cisplatin type DNA-targeted platinum anticancer agents: DNA interactions of novel acridinylthioureas and their platinum conjugatesQ44068264
Bis(acridinylthiourea)platinum(II) complexes: synthesis, DNA affinity, and biological activity in glioblastoma cellsQ44345465
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectplatinumQ880
P304page(s)5622-5632
P577publication date2005-09-28
P1433published inNucleic Acids ResearchQ135122
P1476titleCharacterization of the bisintercalative DNA binding mode of a bifunctional platinum-acridine agent
P478volume33

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cites work (P2860)
Q38736001A review on acridinylthioureas and its derivatives: biological and cytotoxic activity
Q42271885Complexes of Pd(II) and Pt(II) with 9-aminoacridine: reactions with DNA and study of their antiproliferative activity.
Q33300909Direct observation of the reversible unwinding of a single DNA molecule caused by the intercalation of ethidium bromide
Q34148697Influence of temperature and interactions with ligands on dissociation of dsDNA and ligand-dsDNA complexes of various types of binding. An electrochemical study.
Q38271731Metal complex interactions with DNA.
Q38573079NALDB: nucleic acid ligand database for small molecules targeting nucleic acid.
Q37219550Replacement of a thiourea-S with an amidine-NH donor group in a platinum-acridine antitumor compound reduces the metal's reactivity with cysteine sulfur
Q36710624Structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A
Q36340171Synthesis, aqueous reactivity, and biological evaluation of carboxylic acid ester-functionalized platinum-acridine hybrid anticancer agents
Q52372388The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3.
Q37230414Tuning the DNA conformational perturbations induced by cytotoxic platinum-acridine bisintercalators: effect of metal cis/trans isomerism and DNA threading groups

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