The Receptor for Urokinase-type Plasminogen Activator Regulates Fibronectin Matrix Assembly in Human Skin Fibroblasts

scientific article published on November 5, 2003

The Receptor for Urokinase-type Plasminogen Activator Regulates Fibronectin Matrix Assembly in Human Skin Fibroblasts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M310374200
P953full work available at URLhttp://www.jbc.org/article/S0021925818527551/pdf
https://api.elsevier.com/content/article/PII:S0021925818527551?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0021925818527551?httpAccept=text/xml
https://syndication.highwire.org/content/doi/10.1074/jbc.M310374200
P698PubMed publication ID14602715

P2093author name stringVolodia Gueorguiev
Paula J. McKeown-Longo
Cynthia Wilkins-Port
Elizabeth Monaghan
P2860cites workA family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zonesQ24312023
Modulatory roles for integrin activation and the synergy site of fibronectin during matrix assemblyQ24648437
Urokinase-receptor/integrin complexes are functionally involved in adhesion and progression of human breast cancer in vivoQ28350698
Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective mannerQ30304130
Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc complQ30305582
Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptorQ30310205
Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motilityQ30471919
Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent proteinQ30487311
Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction.Q31506532
Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1.Q33948206
Coexisting conformations of fibronectin in cell culture imaged using fluorescence resonance energy transferQ33951951
The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.Q34009345
Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tensionQ34023635
Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth.Q34026314
uPAR: a versatile signalling orchestratorQ34162183
Stretching fibronectinQ34202734
The ins and outs of fibronectin matrix assemblyQ34213803
Novel purification of vitronectin from human plasma by heparin affinity chromatography.Q34660214
Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo.Q35581806
Binding of plasma fibronectin to cell layers of human skin fibroblastsQ36207559
Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblastsQ36211533
Induction of fibronectin matrix assembly in human fibrosarcoma cells by dexamethasoneQ36216349
Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organizationQ36221243
Inhibition of binding of fibronectin to matrix assembly sites by anti-integrin (alpha 5 beta 1) antibodies.Q36223428
A novel role for the integrin-binding III-10 module in fibronectin matrix assemblyQ36236743
Activation of distinct alpha5beta1-mediated signaling pathways by fibronectin's cell adhesion and matrix assembly domainsQ36255267
Rho-mediated contractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly.Q36289136
A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signalingQ36293395
A novel fibronectin binding site required for fibronectin fibril growth during matrix assemblyQ36376920
A fibronectin self-assembly site involved in fibronectin matrix assembly: reconstruction in a synthetic peptideQ36533193
A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1Q36569275
Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contractionQ37386811
Identification of protein-disulfide isomerase activity in fibronectinQ38327444
Regulation of fibronectin matrix assembly by activated Ras in transformed cellsQ40865497
Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin functionQ40890085
Urokinase-type plasminogen activator binding to its receptor stimulates tumor cell migration by enhancing integrin-mediated signal transductionQ40944982
Force required to break alpha5beta1 integrin-fibronectin bonds in intact adherent cells is sensitive to integrin activation stateQ41036942
Regulation of integrin function by the urokinase receptorQ41168373
Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chainQ41199325
Integrins as promiscuous signal transduction devicesQ41305608
Superfibronectin is a functionally distinct form of fibronectinQ41494889
Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectinQ41812511
Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.Q42122844
Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytesQ42163142
Basolateral distribution of fibronectin matrix assembly sites on vascular endothelial monolayers is regulated by substratum fibronectinQ42454559
Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signalingQ42478267
Regulatory role for SRC and phosphatidylinositol 3-kinase in initiation of fibronectin matrix assemblyQ43931378
Distinct activation states of alpha5beta1 integrin show differential binding to RGD and synergy domains of fibronectinQ44064727
EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinomaQ44068440
Integrin activation by R-ras.Q45995226
Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathwayQ46217115
Localization of the cellular-fibronectin-specific epitope recognized by the monoclonal antibody IST-9 using fusion proteins expressed in E. coli.Q54764950
Localization of urokinase type plasminogen activator to focal adhesions requires ligation of vitronectin integrin receptors.Q64889821
Binding of soluble form of fibroblast surface protein, fibronectin, to collagenQ67675651
Formation of sodium dodecyl sulfate-stable fibronectin multimers. Failure to detect products of thiol-disulfide exchange in cyanogen bromide or limited acid digests of stabilized matrix fibronectinQ71058754
Location of the cell-attachment site in fibronectin with monoclonal antibodies and proteolytic fragments of the moleculeQ72658991
Fibronectin fibrillogenesis involves the heparin II binding domain of fibronectinQ74105765
Functional beta1-integrins release the suppression of fibronectin matrix assembly by vitronectinQ77732912
Inhibition of fibronectin matrix assembly by the heparin-binding domain of vitronectinQ78239979
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectbiochemistryQ7094
cell biologyQ7141
P304page(s)1400-1407
P577publication date2003-11-05
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe receptor for urokinase-type plasminogen activator regulates fibronectin matrix assembly in human skin fibroblasts
The Receptor for Urokinase-type Plasminogen Activator Regulates Fibronectin Matrix Assembly in Human Skin Fibroblasts
P478volume279

Reverse relations

cites work (P2860)
Q41934121A dual role for caveolin-1 in the regulation of fibronectin matrix assembly by uPAR.
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Q47992448Cultivation of human dermal fibroblasts and epidermal keratinocytes on keratin-coated silica bead substrates
Q33396940Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin
Q37472074Expression profiling after retinal detachment and reattachment: a possible role for aquaporin-0.
Q53635997Fibronectin remodelling: cell-mediated regulation of the microenvironment.
Q33655922Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells
Q90237740Induction of migration of periodontal ligament cells by selective regulation of integrin subunits
Q36874368PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins
Q36321377Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.
Q37660895Regulation of cell signalling by uPAR.
Q95276628Shaping Up the Tumor Microenvironment With Cellular Fibronectin
Q37264711Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins
Q46930699Urokinase-type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring Src-dependent transactivation of epidermal growth factor receptor

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