SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation

scientific article published on 22 May 2003

SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M301344200
P698PubMed publication ID12764129

P50authorMichael J. MatunisQ42788903
P2093author name stringCurt M Horvath
Richard S Rogers
P2860cites workDistinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interactionQ22254071
A transcriptional corepressor of Stat1 with an essential LXXLL signature motifQ24290918
The role of STATs in apoptosisQ24301148
Identification of a nuclear Stat1 protein tyrosine phosphataseQ24302061
Inhibition of Stat1-mediated gene activation by PIAS1Q24310082
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNAQ24336371
Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activityQ24531180
Transcription factor Sp3 is silenced through SUMO modification by PIAS1Q24534887
PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodiesQ24599898
Signal transducers and activators of transcription as regulators of growth, apoptosis and breast developmentQ24793150
Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1Q27637899
An E3-like factor that promotes SUMO conjugation to the yeast septinsQ28188846
Involvement of PIAS1 in the sumoylation of tumor suppressor p53Q28189956
A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3Q28201630
Signaling through the JAK/STAT pathway, recent advances and future challengesQ28201804
PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1Q28208433
PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcriptionQ28217862
Specific Inhibition of Stat3 Signal Transduction by PIAS3Q28255665
Stats: transcriptional control and biological impactQ29547776
SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targetingQ29619527
SUMO--nonclassical ubiquitinQ29620234
Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1).Q35836715
Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein bindsQ36432406
A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergyQ39454884
PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases.Q39695522
The small ubiquitin-like modifier-1 (SUMO-1) consensus sequence mediates Ubc9 binding and is essential for SUMO-1 modificationQ43548130
Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1.Q44279178
Potentiation of glucocorticoid receptor transcriptional activity by sumoylationQ51843778
P433issue32
P407language of work or nameEnglishQ1860
P304page(s)30091-30097
P577publication date2003-05-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleSUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation
P478volume278

Reverse relations

cites work (P2860)
Q39927831A conserved catalytic residue in the ubiquitin-conjugating enzyme family.
Q28271534A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes
Q34551874A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells
Q38313567A novel repressor domain is required for maximal growth inhibition by the IRF-1 tumor suppressor
Q35140327Adenovirus Sequesters Phosphorylated STAT1 at Viral Replication Centers and Inhibits STAT Dephosphorylation
Q80622021Altered expression of prolactin receptor-associated signaling proteins in human breast carcinoma
Q51939364Automated identification of SUMOylation sites using mass spectrometry and SUMmOn pattern recognition software
Q39797415BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation
Q37146441Biology and significance of the JAK/STAT signalling pathways
Q39128976Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from Interferons for Cytokine Responses
Q34876834Cloning the human SUMO1 promoter
Q51816792Cobalt Protoporphyrin Upregulates Cyclooxygenase-2 Expression Through a Heme Oxygenase-Independent Mechanism
Q42737623Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO).
Q24644027DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells
Q33316416Differential regulation of the two transcriptional activation domains of the coiled-coil coactivator CoCoA by sumoylation
Q35376317Dysregulation of janus kinases and signal transducers and activators of transcription in cancer
Q28475642Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery
Q43357710Effects of Sijunzi decoction and Yupingfeng powder on expression of janus kinase-signal transducer and activator of transcription signal pathway in the brain of spleen-deficiency model rats
Q42616973Evidence for a functional link between Dd-STATa and Dd-PIAS, a Dictyostelium PIAS homologue
Q30445485Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells
Q26314693Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention
Q25257455Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene
Q50036802Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration.
Q38603654HCV infection, IFN response and the coding and non-coding host cell genome
Q50631183Identification of gene variants associated with hypoxia pathway in acute coronary syndrome: a pilot study
Q36480563Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7)
Q52319726Interferon Independent Non-Canonical STAT Activation and Virus Induced Inflammation.
Q34405609Interferon-stimulated genes: a complex web of host defenses
Q47221276Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism
Q42909663Mimosa: mixture model of co-expression to detect modulators of regulatory interaction
Q34828184Modification of the erythroid transcription factor GATA-1 by SUMO-1.
Q40318695Modulation of the activation of Stat1 by the interferon-gamma receptor complex
Q42355514Multiple Functions of Protein Inhibitor of Activated STAT1 in Regulating Endothelial Cell Proliferation and Inflammation
Q36060432Multisite protein modification and intramolecular signaling
Q39890149Mutually exclusive STAT1 modifications identified by Ubc9/substrate dimerization-dependent SUMOylation
Q55264672On the role of STAT1 and STAT6 ADP-ribosylation in the regulation of macrophage activation.
Q24559766PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73
Q46006991PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity.
Q35128090PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus
Q36105975PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts.
Q39366507PIASx acts as an Elk-1 coactivator by facilitating derepression
Q24293208PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia
Q39896633PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling
Q37823682Phosphorylation meets nuclear import: a review
Q40404178Proteasome-mediated degradation of STAT1alpha following infection of macrophages with Leishmania donovani
Q40622102Protective effect of epigallocatechin-3-gallate on ischemia/reperfusion-induced injuries in the heart: STAT1 silencing flavonoid.
Q40483986Proteins of the PIAS family enhance the sumoylation of the papillomavirus E1 protein.
Q35605437Regulation of JAK-STAT signalling in the immune system
Q47930961Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1.
Q28297056Regulation of cytokine signaling pathways by PIAS proteins
Q28264801Regulation of gene-activation pathways by PIAS proteins in the immune system
Q39376971Responses to Cytokines and Interferons that Depend upon JAKs and STATs
Q28611538SUMO modification of heterogeneous nuclear ribonucleoproteins
Q28243200SUMO wrestling with type 1 diabetes
Q35714635SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation
Q36471374SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy
Q34008085SUMO4 and its role in type 1 diabetes pathogenesis
Q35691533SUMO: a regulator of gene expression and genome integrity.
Q36048656Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas.
Q37859135Signal transducers and activators of transcription—from cytokine signalling to cancer biology
Q37392596Small ubiquitin-like modifiers in cellular malignancy and metastasis
Q40252886Stat1 and SUMO modification
Q34435881Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1.
Q38961119Sumoylation Modulates the Susceptibility to Type 1 Diabetes.
Q37241502Targeting the PIAS1 SUMO ligase pathway to control inflammation
Q38337410The logic of communication: roles for mobile transcription factors in plants
Q39388632The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells.
Q28181614The ‘PINIT’ motif, of a newly identified conserved domain of the PIAS protein family, is essential for nuclear retention of PIAS3L
Q40559915Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification

Search more.