Elongation studies of the human agouti-related protein (AGRP) core decapeptide (Yc[CRFFNAFC]Y) results in antagonism at the mouse melanocortin-3 receptor

scientific article published on February 2003

Elongation studies of the human agouti-related protein (AGRP) core decapeptide (Yc[CRFFNAFC]Y) results in antagonism at the mouse melanocortin-3 receptor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0196-9781(03)00030-5
P698PubMed publication ID12668211

P2093author name stringCarrie Haskell-Luevano
Christine G Joseph
Zhimin Xiang
Rayna M Bauzo
Amanda M Shaw
William J Millard
P2860cites workThe human melanocyte stimulating hormone receptor has evolved to become "super-sensitive" to melanocortin peptidesQ72717608
Controlled syntheses of natural and disulfide-mispaired regioisomers of alpha-conotoxin SIQ73288636
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body massQ74268345
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related proteinQ24314579
The cloning of a family of genes that encode the melanocortin receptorsQ24337156
A role for the melanocortin 4 receptor in sexual functionQ24535020
NMR structure of a minimized human agouti related protein prepared by total chemical synthesisQ27618709
Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activityQ27639143
Molecular determinants of ligand binding to the human melanocortin-4 receptorQ28139113
Molecular determinants of human melanocortin-4 receptor responsible for antagonist SHU9119 selective activityQ28209921
High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related proteinQ28211614
Molecular cloning, expression, and characterization of a fifth melanocortin receptorQ28253614
Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptidesQ28257807
Molecular cloning of a novel human melanocortin receptorQ28263897
Characterization of Agouti-related protein binding to melanocortin receptorsQ28294211
Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptorsQ28294398
Role of melanocortinergic neurons in feeding and the agouti obesity syndromeQ28300979
Targeted disruption of the melanocortin-4 receptor results in obesity in miceQ28302831
Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brainQ28307200
Melanocortin receptor binding determinants in the agouti proteinQ28509746
9-Fluorenylmethoxycarbonyl amino-protecting groupQ29040678
Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesityQ34550036
Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic systemQ36557845
Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinantsQ40806231
The agouti-related protein decapeptide (Yc[CRFFNAFC]Y) possesses agonist activity at the murine melanocortin-1 receptorQ40870482
Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positionsQ40895661
Mutations in the carboxyl terminus of the agouti protein decrease agouti inhibition of ligand binding to the melanocortin receptorsQ41126826
Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin recepQ41301816
Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA.Q43581712
Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylationQ45045420
Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutationQ46131478
Molecular characterization of the mouse agouti locus.Q48143334
Overexpression of Agrt leads to obesity in transgenic mice.Q55067245
Color test for detection of free terminal amino groups in the solid-phase synthesis of peptidesQ56390180
Molecular Basis for the Interaction of [Nle4,d-Phe7]Melanocyte Stimulating Hormone with the Human Melanocortin-1 Receptor (Melanocyte α-MSH Receptor)Q57981267
Solid-phase peptide synthesis using mild base cleavage of N alpha-fluorenylmethyloxycarbonylamino acids, exemplified by a synthesis of dihydrosomatostatinQ67327444
Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamicsQ69360120
A colorimetric assay for measuring activation of Gs- and Gq-coupled signaling pathwaysQ72340910
P433issue2
P1104number of pages8
P304page(s)263-270
P577publication date2003-02-01
P1433published inPeptidesQ7166533
P1476titleElongation studies of the human agouti-related protein (AGRP) core decapeptide (Yc[CRFFNAFC]Y) results in antagonism at the mouse melanocortin-3 receptor
P478volume24

Reverse relations

cites work (P2860)
Q89166481Arg-Phe-Phe d-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Results in Unanticipated Melanocortin-1 Receptor Agonist Profiles
Q35551884Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors
Q35610786Discovery of a β-Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology.
Q40263228Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists
Q34583185Solid-phase peptide head-to-side chain cyclodimerization: Discovery of C2-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors
Q47945714Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacolog
Q37159385The role of the Agouti-Related Protein in energy balance regulation
Q39656887γ2-Melanocyte stimulation hormone (γ2-MSH) truncation studies results in the cautionary note that γ2-MSH is not selective for the mouse MC3R over the mouse MC5R

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