Structure-activity relationship of linear peptide Bu-His6-DPhe7-Arg8-Trp9-Gly10-NH2 at the human melanocortin-1 and -4 receptors: DPhe7 and Trp9 substitution

scientific article published on February 2003

Structure-activity relationship of linear peptide Bu-His6-DPhe7-Arg8-Trp9-Gly10-NH2 at the human melanocortin-1 and -4 receptors: DPhe7 and Trp9 substitution is …
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scholarly articleQ13442814

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P356DOI10.1016/S0960-894X(02)01052-1
P698PubMed publication ID12639550

P2093author name stringLi Chen
Adrian Wai-Hing Cheung
Grazyna Kurylko
Xin-Jie Chu
Joseph Swistok
Keith Yagaloff
Lucia Franco
Waleed Danho
P2860cites workSelective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitroQ28199157
Molecular determinants of human melanocortin-4 receptor responsible for antagonist SHU9119 selective activityQ28209921
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Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe positionQ31089001
Melanocortin receptors: perspectives for novel drugsQ33709299
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Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinantsQ40806231
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Phage display selection on whole cells yields a peptide specific for melanocortin receptor 1.Q41083570
Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin recepQ41301816
A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences.Q41731733
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Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH(2) at the human melanocortin-1 and -4 receptors: arginine substitutionQ44088597
Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH(2) at the human melanocortin-1 and -4 receptors: histidine substitutionQ44239603
Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamicsQ69360120
Cyclic melanotropins. 9. 7-D-Phenylalanine analogues of the active-site sequenceQ70083329
Analogs of MTII, lactam derivatives of alpha-melanotropin, modified at the N-terminus, and their selectivity at human melanocortin receptors 3, 4, and 5Q77998885
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P433issue4
P407language of work or nameEnglishQ1860
P1104number of pages4
P304page(s)649-652
P577publication date2003-02-01
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleStructure-activity relationship of linear peptide Bu-His6-DPhe7-Arg8-Trp9-Gly10-NH2 at the human melanocortin-1 and -4 receptors: DPhe7 and Trp9 substitution
P478volume13