Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells

scientific article published on August 2002

Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0960-9822(02)01076-X
P8608Fatcat IDrelease_rrkmyvtxzbdefkdusyeaufycoq
P698PubMed publication ID12194828
P5875ResearchGate publication ID11193103

P50authorPaul R. ClarkeQ40004249
P2093author name stringWilliam Moore
Chuanmao Zhang
Paul R Clarke
P2860cites workThe Hallmarks of CancerQ221226
Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formationQ22010265
Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)Q24291203
Nuclear import of the ran exchange factor, RCC1, is mediated by at least two distinct mechanismsQ24670107
SUMO-1 targets RanGAP1 to kinetochores and mitotic spindlesQ24671070
The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2)Q27766431
Model of the ran-RCC1 interaction using biochemical and docking experimentsQ28137657
Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome IIIQ29618444
Running on Ran: nuclear transport and the mitotic spindle.Q30657439
Role of importin-beta in coupling Ran to downstream targets in microtubule assemblyQ32067740
Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activitiesQ32083982
The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, karyopherin alpha3/QipQ33896394
Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle?Q34341935
Nucleocytoplasmic transport: Ran, beta and beyondQ34446326
Effects of mutant Ran/TC4 proteins on cell cycle progression.Q38307431
Importin beta is a mitotic target of the small GTPase Ran in spindle assemblyQ40829562
Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosisQ41081110
Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extractsQ43940269
Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly.Q50718013
Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.Q50719496
The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo.Q52122308
The ran GTPase regulates mitotic spindle assembly.Q52535025
Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1Q72403668
Inhibition by anti-RCC1 monoclonal antibodies of RCC1-stimulated guanine nucleotide exchange on Ran GTPaseQ74302945
Functional analysis of the yeast Ran exchange factor Prp20p: in vivo evidence for the RanGTP gradient modelQ74427254
Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound RanQ77767628
Stimulation of microtubule aster formation and spindle assembly by the small GTPase RanQ77767632
P433issue16
P407language of work or nameEnglishQ1860
P1104number of pages6
P304page(s)1442-1447
P577publication date2002-08-01
P1433published inCurrent BiologyQ1144851
P1476titleTargeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells
P478volume12

Reverse relations

cites work (P2860)
Q5325469950 ways to build a spindle: the complexity of microtubule generation during mitosis.
Q78954671A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly
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Q41809452A dynamic mode of mitotic bookmarking by transcription factors
Q51241305Aberrant Meiotic Modulation Partially Contributes to the Lower Germination Rate of Pollen Grains in Maize (Zea mays L.) Under Low Nitrogen Supply.
Q28300268Anchoring RCC1 by the tail
Q97529515Characterization of novel USP6 gene rearrangements in a subset of so-called cellular fibroma of tendon sheath
Q27305266Chromatin binding of RCC1 during mitosis is important for its nuclear localization in interphase
Q50947380Crystal structure of human WBSCR16, an RCC1-like protein in mitochondria.
Q34626099Determinants of human cyclin B1 association with mitotic chromosomes
Q30490680Dynamic localisation of Ran GTPase during the cell cycle
Q30489286Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase
Q35551117Emerging roles of DNA tumor viruses in cell proliferation: new insights into genomic instability.
Q34352051Identification of relevant cancer related-genes in the flat oyster Ostrea edulis affected by disseminated neoplasia
Q41944599Identification of the ISWI Chromatin Remodeling Complex of the Early Branching Eukaryote Trypanosoma brucei.
Q34785457Importin alpha/beta and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal
Q35770518Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores.
Q91451282Inhibition of Karyopherin beta 1 suppresses prostate cancer growth
Q41904811Interaction between methyl CpG-binding protein and ran GTPase during cell division in tobacco cultured cells.
Q36306319Kinetochore fiber formation in animal somatic cells: dueling mechanisms come to a draw
Q30441480Localized RanGTP accumulation promotes microtubule nucleation at kinetochores in somatic mammalian cells
Q48503373Meiotic spindle formation in mammalian oocytes: Implications for human infertility
Q38219034Mitotic spindle multipolarity without centrosome amplification.
Q24302527N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis
Q64246083Novel Ran-RCC1 Inhibitory Peptide-Loaded Nanoparticles Have Anti-Cancer Efficacy In Vitro and In Vivo
Q59661230Nuclear transport erupts on the slopes of Mount Etna
Q36514281Nucleosome functions in spindle assembly and nuclear envelope formation.
Q24675421Nup358 integrates nuclear envelope breakdown with kinetochore assembly
Q30450918Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity.
Q24316034Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells
Q35312135Phosphorylation of Ran-binding protein-1 by Polo-like kinase-1 is required for interaction with Ran and early mitotic progression
Q92755882Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly
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Q60017621Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation
Q36493867Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport
Q51538586Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets.
Q30440076Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1.
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Q38331463Spatial gradients controlling spindle assembly
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Q35746894Specific Cooperation Between Imp-α2 and Imp-β/Ketel in Spindle Assembly During Drosophila Early Nuclear Divisions
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