Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase

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Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/JCS.037259
P932PMC publication ID2720920
P698PubMed publication ID19208764

P50authorJon D LaneQ41780127
P2093author name stringDavid K Moss
Andrew Wilde
P2860cites workA novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complexQ24310068
A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2Q24317523
Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exitQ24534998
Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosisQ24673241
TPX2, A novel xenopus MAP involved in spindle pole organizationQ24685949
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
The Fas-induced apoptosis analyzed by high throughput proteome analysisQ28138074
Dissecting temporal and spatial control of cytokinesis with a myosin II InhibitorQ28183531
Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cellsQ28208657
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbingQ28210013
A guide to choosing fluorescent proteinsQ28282750
Transport into and out of the nucleusQ29615611
Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extractsQ29616137
A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentationQ30478057
Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activitiesQ32083982
The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamicsQ33231728
Extranuclear apoptosis. The role of the cytoplasm in the execution phaseQ33718455
Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.Q33941102
Analysis of a RanGTP-regulated gradient in mitotic somatic cellsQ34506840
Apoptosis in systemic lupus erythematosusQ35213877
Apoptotic membrane blebbing is regulated by myosin light chain phosphorylationQ36274919
Actin-myosin-based contraction is responsible for apoptotic nuclear disintegrationQ36321103
Cellular stresses induce the nuclear accumulation of importin alpha and cause a conventional nuclear import blockQ36322431
A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivoQ36324250
Caspases disrupt the nuclear-cytoplasmic barrierQ36326441
Nuclear transport is becoming crystal clearQ36372013
Ran at a glanceQ36576635
Spatial and temporal coordination of mitosis by Ran GTPaseQ37163028
Importin alpha-regulated nucleation of microtubules by TPX2.Q39756365
The apoptotic microtubule network preserves plasma membrane integrity during the execution phase of apoptosisQ40179751
Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells.Q40380123
NuMA, a nuclear protein involved in mitosis and nuclear reformation.Q40626418
Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cellsQ40708712
Nuclear envelope breakdown proceeds by microtubule-induced tearing of the laminaQ40757025
Polymerization of tubulin in apoptotic cells is not cell cycle dependentQ41415277
Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dyneinQ42855052
Caspases mediate nucleoporin cleavage, but not early redistribution of nuclear transport factors and modulation of nuclear permeability in apoptosisQ43652156
Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly.Q50718013
Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.Q50719496
Apoptotic cleavage of NuMA at the C-terminal end is related to nuclear disruption and death amplification.Q52578115
Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activationQ60017621
Multiple centrosomal microtubule organising centres and increased microtubule stability are early features of VP-16-induced apoptosis in CCRF-CEM cellsQ60510140
Cleavage of the nuclear matrix protein NuMA during apoptosisQ73417354
Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosisQ77726315
Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound RanQ77767628
Stimulation of microtubule aster formation and spindle assembly by the small GTPase RanQ77767632
Microtubules: forgotten players in the apoptotic execution phaseQ83963325
P433issuePt 5
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)644-655
P577publication date2009-02-10
P1433published inJournal of Cell ScienceQ1524177
P1476titleDynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase
P478volume122