Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

scientific article published on March 2000

Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI5656
P932PMC publication ID377454
P698PubMed publication ID10727441
P5875ResearchGate publication ID245721056

P50authorMireia PelegrinQ38600930
Anna PujolQ42409760
Fatima BoschQ57321512
Alba CasellasQ59686637
P2093author name stringM George
J Visa
L Gros
J C Devedjian
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Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia.Q52534808
Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.Q53472225
The influence of genetic background on the expression of the obese (ob) gene in the mouseQ53909983
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.Q54104864
Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man.Q54194095
Muscle insulin resistance may not be a primary etiological factor in the genetically obese fa/fa ratQ54274779
Genetic analysis of genomic imprinting: An Imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locusQ57406125
Compensatory Growth of Pancreatic -Cells in Adult Rats After Short-Term Glucose InfusionQ60192459
Expression of GLUT-2 antisense RNA in beta cells of transgenic mice leads to diabetesQ62067337
What if Minkowski had been ageusic? An alternative angle on diabetesQ67584870
Patients with insulinoma show insulin resistance in the absence of arterial hypertensionQ68095606
Insulin-like growth factor-I at physiological concentrations is a potent inhibitor of insulin secretionQ68931602
Structural changes of pancreatic islets in genetically obese ratsQ69315092
Evidence for the presence of type I insulin-like growth factor receptors on rat pancreatic A and B cellsQ70039668
Hepatic overexpression of insulin-like growth factor-II in adulthood increases basal and insulin-stimulated glucose disposal in conscious miceQ70870845
Insulin and multiplication stimulating activity (an insulin-like growth factor) stimulate islet (beta-cell replication in neonatal rat pancreatic monolayer culturesQ71470131
Interactions of nutrients, insulin-like growth factors (IGFs) and IGF-binding proteins in the regulation of DNA synthesis by isolated fetal rat islets of LangerhansQ71605228
Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty RatQ71816876
Comparison of insulin sensitivity in patients with insulinoma and obese Type 2 diabetes mellitusQ71876464
Immunohistochemical localization of insulin-like growth factor 1 and 2 in the endocrine pancreas of rat, dog, and man, and their coexistence with classical islet hormonesQ72230950
The type II insulin-like growth factor receptor does not mediate increased DNA synthesis in H-35 hepatoma cellsQ72397823
Glucose metabolism in transgenic mice containing a chimeric P-enolpyruvate carboxykinase/bovine growth hormone geneQ72829677
Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factorsQ73070782
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null allelesQ73085036
Ultrastructural localization of insulin-like growth factor-2 (IGF-2) to the secretory granules of insulin cells: a study in normal and diabetic (GK) ratsQ73632893
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecttype 2 diabetesQ3025883
preproinsulinQ7240673
overexpressionQ61643320
P304page(s)731-740
P577publication date2000-03-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleTransgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes
P478volume105

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