| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M003188200 |
| P698 | PubMed publication ID | 10952976 |
| P50 | author | Rachel C. Chambers | Q51462038 |
| Olivier Blanc-Brude | Q56452079 | ||
| P2093 | author name string | P Leoni | |
| G J Laurent | |||
| D E Wembridge | |||
| P433 | issue | 45 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | connective tissue | Q25615 |
| proteolysis | Q33123 | ||
| P304 | page(s) | 35584-35591 | |
| P577 | publication date | 2000-11-01 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1 | |
| P478 | volume | 275 |
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| Q23915016 | A peptide from thrombospondin 1 modulates experimental erosive arthritis by regulating connective tissue growth factor |
| Q41791167 | A role for thrombin in liver fibrosis |
| Q89104348 | ADAM17/EGFR-dependent ERK activation mediates thrombin-induced CTGF expression in human lung fibroblasts |
| Q28512580 | Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis |
| Q35363647 | Activation of protease-activated receptors (PARs)-1 and -2 promotes alpha-smooth muscle actin expression and release of cytokines from human lung fibroblasts |
| Q51024108 | Activation of transforming growth factor-β1 by thrombin via integrins αvβ1, αvβ3, and αvβ5 in buccal fibroblasts: Suppression by epigallocatechin-3-gallate. |
| Q41171155 | Antifibrotic effect of heparin on liver fibrosis model in rats |
| Q34917680 | Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease |
| Q39479909 | Assembly of the prothrombinase complex on the surface of human foreskin fibroblasts: Implications for connective tissue growth factor |
| Q92670007 | Bazedoxifene enhances paclitaxel efficacy to suppress glioblastoma via altering Hippo/YAP pathway |
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| Q34770486 | Coagulation and autoimmunity in scleroderma interstitial lung disease. |
| Q38026809 | Coagulation cascade proteinases in lung injury and fibrosis |
| Q34560721 | Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis |
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| Q33722844 | Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts. |
| Q42006595 | Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis. |
| Q35628568 | Disorders of lung matrix remodeling |
| Q46553051 | Downregulation of protease-activated receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E receptor EP2 through cAMP elevation and protein kinase A. |
| Q57465099 | Effect of ambient particulate matter exposure on hemostasis |
| Q43180245 | Escape from the matrix: multiple mechanisms for fibroblast activation in pulmonary fibrosis |
| Q35791283 | Expression of protease-activated receptor-1, -2, -3, and -4 in control and experimentally inflamed mouse bladder |
| Q81281892 | Expression of protease-activated receptors and tissue factor in human liver |
| Q44286064 | Expression of proteinase-activated receptor 2 during taurocholate-induced acute pancreatic lesion development in Wistar rats |
| Q43765105 | Expression of the thrombin receptor (PAR-1) during rat skeletal muscle differentiation |
| Q54758416 | Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts. |
| Q36778823 | Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice |
| Q73371698 | Fibrogenic signals in patients with radiation enteritis are associated with increased connective tissue growth factor expression |
| Q45184208 | Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program |
| Q34976913 | Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? |
| Q58698399 | Hematopoietic protease nexin-1 protects against lung injury by preventing thrombin signaling in mice |
| Q36363953 | Highly selective and rapidly activatable fluorogenic Thrombin sensors and application in human lung tissue |
| Q44512712 | Hirulog-like peptide reduces restenosis and expression of tissue factor and transforming growth factor-beta in carotid artery of atherosclerotic rabbits |
| Q41983248 | Identification of human ccn2 (connective tissue growth factor) promoter polymorphisms |
| Q28344134 | Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients |
| Q33283747 | Induction of MMP-9 release from human dermal fibroblasts by thrombin: involvement of JAK/STAT3 signaling pathway in MMP-9 release |
| Q46189402 | Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model |
| Q80839683 | Interstitial lung disease in systemic sclerosis |
| Q51418425 | MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts. |
| Q27023971 | Mechanisms of alveolar epithelial injury, repair, and fibrosis |
| Q36237168 | Molecular and cellular mechanisms of pulmonary fibrosis |
| Q46236843 | Multiple enhancer regions govern the transcription of CCN2 during embryonic development. |
| Q38153815 | New treatment and markers of prognosis for idiopathic pulmonary fibrosis: lessons learned from translational research |
| Q34903224 | Novel therapeutic approaches for pulmonary fibrosis |
| Q43991324 | PAI-1 promotes extracellular matrix deposition in the airways of a murine asthma model |
| Q40591380 | PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation |
| Q36544217 | PAR1 participates in the ability of multidrug resistance and tumorigenesis by controlling Hippo-YAP pathway |
| Q36497048 | Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention? |
| Q39158447 | Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation |
| Q46930486 | Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis |
| Q34175474 | Protease-activated receptors in inflammation, neuronal signaling and pain |
| Q37520695 | Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages |
| Q37024500 | Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. |
| Q43125135 | Quality of thrombin produced from the patient's own plasma using the TPD, a new Thrombin-processing Device. |
| Q35597990 | Quantitative gene expression in Budd-Chiari syndrome: a molecular approach to the pathogenesis of the disease. |
| Q38187607 | Recent advances in understanding the pathogenesis of scleroderma-interstitial lung disease |
| Q39279928 | Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). |
| Q28354904 | Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy |
| Q53255805 | Role of protease-activated receptor-2 in idiopathic pulmonary fibrosis. |
| Q34874973 | Role of protease-activated receptors in airway function: a target for therapeutic intervention? |
| Q91235944 | Shared and distinct mechanisms of fibrosis |
| Q36779216 | Signaling pathways involved in proteinase-activated receptor1-induced proinflammatory and profibrotic mediator release following lung injury. |
| Q36024850 | Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism |
| Q33362184 | Special considerations with fondaparinux therapy: heparin-induced thrombocytopenia and wound healing |
| Q36350579 | Stanniocalcin-1 inhibits thrombin-induced signaling and protects from bleomycin-induced lung injury |
| Q36053014 | Structural and functional properties of CCN proteins |
| Q39024744 | Targeting coagulation factor receptors - protease-activated receptors in idiopathic pulmonary fibrosis |
| Q37972789 | Targeting proteinase-activated receptors: therapeutic potential and challenges. |
| Q48292789 | The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells. |
| Q51770077 | The development of cardiac fibrosis in low tissue factor mice is gender-dependent and is associated with differential regulation of urokinase plasminogen activator. |
| Q60691055 | The inflammatory response |
| Q54996240 | Thrombin and factor Xa link the coagulation system with liver fibrosis. |
| Q53672014 | Thrombin is a pro-fibrotic factor for rat renal fibroblasts in vitro. |
| Q40745704 | Thrombin-induced CCN2 expression as a target for anti-fibrotic therapy in scleroderma |
| Q39252052 | Thrombin-induced CCN2 expression in human lung fibroblasts requires the c-Src/JAK2/STAT3 pathway. |
| Q85003226 | Thrombin-stimulated connective tissue growth factor (CTGF/CCN2) production in human buccal mucosal fibroblasts: Inhibition by epigallocatechin-3-gallate |
| Q35106408 | Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells |
| Q33799846 | Transforming growth factor-β1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts |
| Q33631115 | Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis |
| Q37196021 | Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis |
| Q82103488 | [Thrombin generation in critical illnesses] |
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