The development of cardiac fibrosis in low tissue factor mice is gender-dependent and is associated with differential regulation of urokinase plasminogen activator.

scientific article published on 17 January 2007

The development of cardiac fibrosis in low tissue factor mice is gender-dependent and is associated with differential regulation of urokinase plasminogen activator. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YJMCC.2006.11.017
P698PubMed publication ID17234207

P50authorSean E KennedyQ79294806
P2093author name stringNigel Mackman
Jonathan H Erlich
Kate Wilson
John A Charlesworth
Darren R Davis
Melissa J Sam
P2860cites workInterplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodelingQ33895464
Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunctionQ34385821
Matrix metalloproteinases: regulation and dysregulation in the failing heartQ34574541
Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction.Q35083397
Pathologic hypertrophy with fibrosis: the structural basis for myocardial failureQ35284582
Matrix metalloproteinases A review of their structure and role in acute coronary syndromeQ35557333
Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factorQ35559979
Gender modulates cardiac phenotype development in genetically modified miceQ35846955
Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: a temporal and spatial windowQ36344710
Low levels of tissue factor are compatible with development and hemostasis in mice.Q37377780
Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in miceQ38584976
Regulation of vascular endothelial growth factor (VEGF) production and angiogenesis by tissue Factor (TF) in SGC-7901 gastric cancer cellsQ40431822
A quantitative real-time PCR method for tissue factor mRNA.Q40589336
Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1.Q40859813
Vascular endothelial growth factor production by fibroblasts in response to factor VIIa binding to tissue factor involves thrombin and factor Xa.Q40880354
Neonatal estrogen stimulates proliferation of periductal fibroblasts and alters the extracellular matrix composition in the rat prostateQ42466503
CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosisQ42494057
Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditisQ43939993
Activation of matrix metalloproteinases precedes left ventricular remodeling in hypertensive heart failure rats: its inhibition as a primary effect of Angiotensin-converting enzyme inhibitorQ44820276
Role of tissue factor in embryonic blood vessel development.Q45878003
Development and disease in proteinase-deficient mice: role of the plasminogen, matrix metalloproteinase and coagulation systemQ45889584
Alterations in myocardial tissue factor expression and cellular localization in dilated cardiomyopathyQ46420655
Mechanisms of cardiac fibrosis induced by urokinase plasminogen activator.Q53631087
Role of tissue factor in haemostasis, thrombosis, angiogenesis and inflammation: lessons from low tissue factor mice.Q54036709
The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological ActivitiesQ59261168
A Matrix Metalloproteinase Induction/Activation System Exists in the Human Left Ventricular Myocardium and Is Upregulated in Heart FailureQ59599298
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failureQ62383757
Thrombin increases proliferation and decreases fibrinolytic activity of kidney glomerular epithelial cellsQ67912533
Myocardial fibrosis in the rat with mineralocorticoid excess. Prevention of scarring by amilorideQ72861447
Stromelysin (MMP-3) synthesis is up-regulated in estrogen-deficient mouse osteoblasts in vivo and in vitroQ73204923
Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted ratQ73693685
Thrombin receptor-mediated increase of two matrix metalloproteinases, MMP-1 and MMP-3, in human endothelial cellsQ73832884
Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitroQ74214063
Vascular endothelial growth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: conversion of prothrombin to thrombin results in progelatinase A activation and cell proliferationQ74292354
Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of flt-1Q77426354
Overexpression of urokinase by macrophages or deficiency of plasminogen activator inhibitor type 1 causes cardiac fibrosis in miceQ80422543
A balance between tissue factor and tissue factor pathway inhibitor is required for embryonic development and hemostasis in adult miceQ81144269
The plasminogen-MMP system is more activated in the scar than in viable myocardium 3 months post-MI in the ratQ81208214
P433issue3
P304page(s)559-571
P577publication date2007-01-17
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleThe development of cardiac fibrosis in low tissue factor mice is gender-dependent and is associated with differential regulation of urokinase plasminogen activator
P478volume42