Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide

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Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide is …
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scholarly articleQ13442814

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P356DOI10.1042/0264-6021:3460767
P932PMC publication ID1220911
P698PubMed publication ID10698705
P5875ResearchGate publication ID12616375

P2093author name stringSchmidt HH
Pfleiderer W
Horejsi R
Kotsonis P
Fröhlich LG
Shutenko ZV
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Tetrahydrobiopterin preferentially stimulates activity and promotes subunit aggregation of membrane-bound calcium-dependent nitric oxide synthase in human placentaQ73544629
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Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal centerQ27766420
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Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin.Q30423824
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Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxideQ37310818
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Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injuryQ37542333
Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginineQ37576988
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NO at workQ40630836
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Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer.Q40788969
Mechanism of superoxide generation by neuronal nitric-oxide synthaseQ40964927
Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate-liganded heme protein that hydroxylates L-arginine to produce NO. as a cellular signal.Q40981973
Reaction of neuronal nitric-oxide synthase with oxygen at low temperature. Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin.Q41037639
Optical difference spectrophotometry as a probe of rat brain nitric oxide synthase heme-substrate interactionQ41526294
Generation of superoxide by purified brain nitric oxide synthaseQ41590269
Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.Q41758509
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Overexpression of neuronal nitric oxide synthase in insect cells reveals requirement of haem for tetrahydrobiopterin bindingQ42064550
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Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthaseQ42706218
Allosteric modulation of rat brain nitric oxide synthase by the pterin-site enzyme inhibitor 4-aminotetrahydrobiopterinQ42988594
Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity.Q42993827
Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactorQ46208596
Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.Q46275700
The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domainQ48123444
NG-nitro-L-[3H]arginine binding properties of neuronal nitric oxide synthase in rat brainQ48794457
Inducible nitric-oxide synthase generates superoxide from the reductase domainQ57220882
Involvement of the reductase domain of neuronal nitric oxide synthase in superoxide anion productionQ57221106
Tetrahydrobiopterin-Free Neuronal Nitric Oxide Synthase: Evidence for Two Identical Highly Anticooperative Pteridine Binding Sites†Q61906313
Role of tetrahydrobiopterin availability in the regulation of nitric-oxide synthase expression in human mesangial cellsQ71143256
P407language of work or nameEnglishQ1860
P921main subjectsapropterinQ419808
P304page(s)767-776
P577publication date2000-03-01
P1433published inBiochemical JournalQ864221
P1476titleAllosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide
P478volume346 Pt 3

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cites work (P2860)
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