Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes

scientific article

Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1046181199
P356DOI10.1038/SJ.ONC.1203261
P698PubMed publication ID10644994
P5875ResearchGate publication ID12669549

P50authorJoseph R SlupskyQ38322946
P2093author name stringBlock C
Rapp UR
Herrmann C
Weber CK
Schuler M
P2860cites workThe complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirusQ22254864
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1Q24309607
Ras/Rap effector specificity determined by charge reversalQ24315941
The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogueQ24323252
The RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activationQ24522806
Activation of ternary complex factor Elk-1 by MAP kinasesQ24564310
Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of JunQ28283776
Two distinct Raf domains mediate interaction with RasQ28300500
The ins and outs of Raf kinasesQ28307284
Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinasesQ28609156
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membraneQ29618478
Activation of Raf as a result of recruitment to the plasma membraneQ29618481
A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 functionQ30454014
Taxonomy and function of C1 protein kinase C homology domainsQ36280307
Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinaseQ38298684
Analysis of the ERK-stimulated ETS transcription factor ER81.Q40018533
Genetics of signal transduction in invertebratesQ40757559
Discrimination of amino acids mediating Ras binding from noninteracting residues affecting raf activation by double mutant analysisQ41075527
Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1.Q41092757
Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factorQ41214472
How Ras-related proteins talk to their effectorsQ41331175
Ras and its effectorsQ41434222
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinaseQ42820729
Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.Q45971337
Conspiracy theory: RAS and RAF do not act aloneQ46050993
Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivoQ71011188
Differential regulation of Raf isozymes by growth versus differentiation inducing factors in PC12 pheochromocytoma cellsQ71118388
A novel strategy for the immunological tagging of cDNA constructsQ71605954
Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinaseQ77195536
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)169-176
P577publication date2000-01-01
P1433published inOncogeneQ1568657
P1476titleMitogenic signaling of Ras is regulated by differential interaction with Raf isozymes
P478volume19

Reverse relations

cites work (P2860)
Q38618036A-Raf: A new star of the family of raf kinases
Q35117306Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.
Q34728330An old kinase on a new path: Raf and apoptosis
Q40749465Anti-(Raf-1) RNA aptamers that inhibit Ras-induced Raf-1 activation.
Q40738261Associations of B- and C-Raf with cholesterol, phosphatidylserine, and lipid second messengers: preferential binding of Raf to artificial lipid rafts.
Q40106302B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding
Q24791830Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis
Q34293560Development of anticancer drugs targeting the MAP kinase pathway
Q42416308Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation
Q50643518Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration.
Q39260997Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes
Q50917827Genomic insights into head and neck cancer.
Q28203433Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms
Q41792391Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.
Q35635353JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis
Q40790669P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.
Q45065372Piconewton-Scale Analysis of Ras-BRaf Signal Transduction with Single-Molecule Force Spectroscopy
Q42799900Point mutants of c-raf-1 RBD with elevated binding to v-Ha-Ras
Q24316181Raf family kinases: old dogs have learned new tricks
Q41887999Raf-1 regulates Rho signaling and cell migration
Q35459718Rafs constitute a nodal point in the regulation of embryonic endothelial progenitor cell growth and differentiation
Q37822317Role of Ras/Raf/MEK/ERK signaling in physiological hematopoiesis and leukemia development
Q47144786SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a.
Q34348449Searching new targets for anticancer drug design: the families of Ras and Rho GTPases and their effectors
Q54108531Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.
Q35166852Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.
Q34358419Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis
Q35020561Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies
Q36283341The Kinase Activity-deficient Isoform of the Protein Araf Antagonizes Ras/Mitogen-activated Protein Kinase (Ras/MAPK) Signaling in the Zebrafish Embryo
Q29620153The RAF proteins take centre stage
Q34605237The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

Search more.