Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies

scientific article

Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1517/14728222.6.6.659
P698PubMed publication ID12472379

P50authorJames A. McCubreyQ42317570
P2093author name stringJohn T Lee
P2860cites workRaf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanismQ24633458
Mutations of the BRAF gene in human cancerQ27860760
90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.Q27863657
From receptors to stress-activated MAP kinasesQ28137773
The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperoneQ28143894
GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteinsQ28145018
Kinase suppressor of Ras is ceramide-activated protein kinaseQ28307245
The primary structure of MEK, a protein kinase that phosphorylates the ERK gene productQ28316871
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivoQ28368373
Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugsQ28609063
Isotype-specific functions of Raf kinasesQ33783496
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptorQ33945092
ERK2 enters the nucleus by a carrier-independent mechanismQ34064164
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogsQ34124337
Kinases: positive and negative regulators of apoptosis.Q34144498
The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumorsQ34241295
Oligonucleotide treatment of ras-induced tumors in nude miceQ34300042
Suppression of apoptosis: role in cell growth and neoplasiaQ34309816
Complex formation between RAS and RAF and other protein kinasesQ34351032
Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.Q34394101
Farnesyltransferase inhibitors: mechanism and applicationsQ34481874
Pharmacological inhibitors of MAPK pathways.Q34502720
Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas?Q34537883
Farnesyl transferase inhibitors: a novel targeted tnerapy for cancerQ34571777
p21-activated kinases: three more join the Pak.Q34598122
Ras/Raf signalling and emerging pharmacotherapeutic targetsQ34660771
Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancerQ36623268
Molecular determinants that mediate selective activation of p38 MAP kinase isoformsQ40387373
Signaling by the cytokine receptor superfamily: JAKs and STATs.Q40682061
Phosphorylation site specificity of the Pak-mediated regulation of Raf-1 and cooperativity with Src.Q40803062
Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymesQ40904290
Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entryQ40976467
Activation of Raf-1 by interferon gamma and oncostatin M requires expression of the Stat1 transcription factorQ41024206
Signaling molecules involved in coupling growth hormone receptor to mitogen-activated protein kinase activationQ42445122
Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.Q42808825
A distinct class of dominant negative Ras mutants: cytosolic GTP-bound Ras effector domain mutants that inhibit Ras signaling and transformation and enhance cell adhesionQ42819601
The p38 MAP kinase pathway and its biological functionQ43974407
Ro 09-2210 exhibits potent anti-proliferative effects on activated T cells by selectively blocking MKK activityQ47900805
Competitive inhibition of MAP kinase activation by a peptide representing the alpha C helix of ERK.Q47943241
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)659-678
P577publication date2002-12-01
P1433published inExpert Opinion on Therapeutic TargetsQ5421214
P1476titleTargeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies
P478volume6

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cites work (P2860)
Q36973814Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy
Q36836817Are MAP kinases drug targets? Yes, but difficult ones
Q24809688BAG-1 haplo-insufficiency impairs lung tumorigenesis
Q37109227Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.
Q40635020Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation
Q34184917Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.
Q35635353JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis
Q34303405Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis
Q40560220Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection.
Q37865381Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.
Q36407379Sorafenib
Q36995054Targeting prostate cancer based on signal transduction and cell cycle pathways.
Q40154931Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.
Q36268324The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?
Q37837732Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.