review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.1517/14728222.6.6.659 |
P698 | PubMed publication ID | 12472379 |
P50 | author | James A. McCubrey | Q42317570 |
P2093 | author name string | John T Lee | |
P2860 | cites work | Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism | Q24633458 |
Mutations of the BRAF gene in human cancer | Q27860760 | ||
90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. | Q27863657 | ||
From receptors to stress-activated MAP kinases | Q28137773 | ||
The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone | Q28143894 | ||
GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins | Q28145018 | ||
Kinase suppressor of Ras is ceramide-activated protein kinase | Q28307245 | ||
The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product | Q28316871 | ||
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo | Q28368373 | ||
Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs | Q28609063 | ||
Isotype-specific functions of Raf kinases | Q33783496 | ||
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor | Q33945092 | ||
ERK2 enters the nucleus by a carrier-independent mechanism | Q34064164 | ||
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs | Q34124337 | ||
Kinases: positive and negative regulators of apoptosis. | Q34144498 | ||
The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors | Q34241295 | ||
Oligonucleotide treatment of ras-induced tumors in nude mice | Q34300042 | ||
Suppression of apoptosis: role in cell growth and neoplasia | Q34309816 | ||
Complex formation between RAS and RAF and other protein kinases | Q34351032 | ||
Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization. | Q34394101 | ||
Farnesyltransferase inhibitors: mechanism and applications | Q34481874 | ||
Pharmacological inhibitors of MAPK pathways. | Q34502720 | ||
Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas? | Q34537883 | ||
Farnesyl transferase inhibitors: a novel targeted tnerapy for cancer | Q34571777 | ||
p21-activated kinases: three more join the Pak. | Q34598122 | ||
Ras/Raf signalling and emerging pharmacotherapeutic targets | Q34660771 | ||
Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancer | Q36623268 | ||
Molecular determinants that mediate selective activation of p38 MAP kinase isoforms | Q40387373 | ||
Signaling by the cytokine receptor superfamily: JAKs and STATs. | Q40682061 | ||
Phosphorylation site specificity of the Pak-mediated regulation of Raf-1 and cooperativity with Src. | Q40803062 | ||
Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes | Q40904290 | ||
Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry | Q40976467 | ||
Activation of Raf-1 by interferon gamma and oncostatin M requires expression of the Stat1 transcription factor | Q41024206 | ||
Signaling molecules involved in coupling growth hormone receptor to mitogen-activated protein kinase activation | Q42445122 | ||
Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. | Q42808825 | ||
A distinct class of dominant negative Ras mutants: cytosolic GTP-bound Ras effector domain mutants that inhibit Ras signaling and transformation and enhance cell adhesion | Q42819601 | ||
The p38 MAP kinase pathway and its biological function | Q43974407 | ||
Ro 09-2210 exhibits potent anti-proliferative effects on activated T cells by selectively blocking MKK activity | Q47900805 | ||
Competitive inhibition of MAP kinase activation by a peptide representing the alpha C helix of ERK. | Q47943241 | ||
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 659-678 | |
P577 | publication date | 2002-12-01 | |
P1433 | published in | Expert Opinion on Therapeutic Targets | Q5421214 |
P1476 | title | Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies | |
P478 | volume | 6 |
Q36973814 | Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy |
Q36836817 | Are MAP kinases drug targets? Yes, but difficult ones |
Q24809688 | BAG-1 haplo-insufficiency impairs lung tumorigenesis |
Q37109227 | Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. |
Q40635020 | Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation |
Q34184917 | Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. |
Q35635353 | JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis |
Q34303405 | Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis |
Q40560220 | Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection. |
Q37865381 | Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. |
Q36407379 | Sorafenib |
Q36995054 | Targeting prostate cancer based on signal transduction and cell cycle pathways. |
Q40154931 | Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance. |
Q36268324 | The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it? |
Q37837732 | Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways. |