The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes

scientific article

The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/(SICI)1097-0134(199701)27:1<96::AID-PROT10>3.0.CO;2-D
P698PubMed publication ID9037715

P2093author name stringGrötzinger J
Rose-John S
Kurapkat G
Wollmer A
Kalai M
P2860cites workThe X-ray structure of a growth hormone-prolactin receptor complexQ24309612
Human ciliary neurotrophic factor: a structure-function analysisQ38293879
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)96-109
P577publication date1997-01-01
P1433published inProteinsQ7251514
P1476titleThe family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes
P478volume27

Reverse relations

cites work (P2860)
Q62658923A bioactive designer cytokine for human hematopoietic progenitor cell expansion
Q30332200A structural template for gp130-cytokine signaling assemblies.
Q33254113Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display
Q41048286Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions
Q41077278Analysis of the Mechanism of Action of Anti‐human Interleukin‐6 and Anti‐human Interleukin‐6 Receptor‐neutralising Monoclonal Antibodies
Q36605485Bioengineered nerve regeneration and muscle reinnervation
Q33349514Characterization of a potent human interleukin-11 agonist
Q35743839Cytokine homologs of human gammaherpesviruses
Q28145310Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis
Q73487697Different epitopes are required for gp130 activation by interleukin-6, oncostatin M and leukemia inhibitory factor
Q28209470Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy
Q77470230Engineering and use of 32P‐labeled human recombinant interleukin‐11 for receptor binding studies
Q45007823Functional implications of large backbone amplitude motions of the glycoprotein 130-binding epitope of interleukin-6.
Q35323328Heart regeneration, stem cells, and cytokines
Q41869575Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice
Q39593637High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ‐secretase inhibitor, RO4929097
Q37412993IL-6-mediated induction of matrix metalloproteinase-9 is modulated by JAK-dependent IL-10 expression in macrophages
Q22254431Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R
Q36495258Interleukin-6 and its receptor: from bench to bedside
Q24531184Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
Q52960794Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M.
Q83225765Kinetics of cytokine receptor trafficking determine signaling and functional selectivity
Q41017172Minimal interleukin 6 (IL-6) receptor stalk composition for IL-6 receptor shedding and IL-6 classic signaling
Q73692223Molecular Modeling-guided Mutagenesis of the Extracellular Part of gp130 Leads to the Identification of Contact Sites in the Interleukin-6 (IL-6)·IL-6 receptor·gp130 Complex
Q33737440Molecular mechanisms regulating motor neuron development and degeneration.
Q33746118Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors
Q28505506Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor
Q34073721New perspectives on the design of cytokines and growth factors.
Q36283919Novel Insights into Interleukin 6 (IL-6) Cis- and Trans-signaling Pathways by Differentially Manipulating the Assembly of the IL-6 Signaling Complex
Q40028531Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors
Q22010578Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family
Q40952738Oncostatin M Induces Heat Hypersensitivity by gp130-Dependent Sensitization of TRPV1 in Sensory Neurons
Q40320402Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism.
Q81060793Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brain
Q30322247Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.
Q35925860Shared cytokine signaling receptors: structural insights from the gp130 system
Q24297991Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF
Q28817043Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database
Q51787521Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.
Q38315557Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies
Q38334627The Membrane Proximal Cytokine Receptor Domain of the Human Interleukin-6 Receptor Is Sufficient for Ligand Binding but Not for gp130 Association
Q54563031The Signal Transducer Gp130 — Bacterial Expression, Refolding and Properties of the Carboxy‐Terminal Domain of the Cytokine‐Binding Module
Q41847430The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).
Q24297675The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane
Q38334177The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor
Q34991808The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex
Q27617965The signal transducer gp130: Solution structure of the carboxy-terminal domain of the cytokine receptor homology region
Q34430168The therapeutic potential of interleukin-6 hyperagonists and antagonists
Q94512263Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells

Search more.