HIV-1 Vpr- and Reverse Transcription-Induced Apoptosis in Resting Peripheral Blood CD4 T Cells and Protection by Common Gamma-Chain Cytokines

scientific article published on 4 November 2015

HIV-1 Vpr- and Reverse Transcription-Induced Apoptosis in Resting Peripheral Blood CD4 T Cells and Protection by Common Gamma-Chain Cytokines is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.01770-15
P932PMC publication ID4702666
P698PubMed publication ID26537673

P2093author name stringDavid N Levy
Benjamin Trinité
Chi N Chan
Caroline S Lee
P2860cites workThe HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition poreQ22011015
HIV-1 induced bystander apoptosisQ22241221
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infectionQ22251080
IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIVQ24567990
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by VpxQ24605940
SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cellsQ24615124
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesQ24624362
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 proteinQ24635842
The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycleQ24685965
HIV restriction in quiescent CD4⁺ T cellsQ26995784
HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cellsQ28208528
Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanismQ28245301
HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structureQ28283258
Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cellsQ28299900
Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latencyQ28728736
The ribonuclease activity of SAMHD1 is required for HIV-1 restrictionQ29147390
Early Events in Sexual Transmission of HIV and SIV and Opportunities for InterventionsQ30395919
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.Q30421200
Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cellsQ30789734
The HIV envelope but not VSV glycoprotein is capable of mediating HIV latent infection of resting CD4 T cellsQ33511958
Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cellsQ33783211
Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycleQ33849340
HIV-1 replication is controlled at the level of T cell activation and proviral integrationQ33919765
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viabilityQ33921263
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivoQ33924186
Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory proteinQ33926275
Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeysQ34020988
Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuliQ34124009
Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissueQ34152017
Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodesQ34297394
Modalities of interleukin-7-induced human immunodeficiency virus permissiveness in quiescent T lymphocytesQ34344987
HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration.Q34348888
Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T CellsQ34491597
Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivoQ34585676
Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4.Q34872907
In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cellsQ34977020
Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cellsQ35077587
HIV-1 pathogenesisQ35166833
Suppression of Foxo1 activity and down-modulation of CD62L (L-selectin) in HIV-1 infected resting CD4 T cellsQ35350405
HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells.Q35661660
Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cellsQ35785154
Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infectionQ36225040
Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytesQ36368207
Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4Q36380382
SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferonsQ36480173
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.Q37090120
An HIV-1 replication pathway utilizing reverse transcription products that fail to integrateQ37336473
Dynamics of HIV-1 recombination in its natural target cellsQ37356815
HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cellsQ37485148
Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo.Q37581155
HIV-1 Vpr-a still "enigmatic multitasker".Q37689513
Flow cytometry based assays for the measurement of apoptosis-associated mitochondrial membrane depolarisation and cytochrome c releaseQ38094830
Restrictions to HIV-1 replication in resting CD4+ T lymphocytesQ38111619
Quiescence and attenuated DNA damage response promote survival of esophageal cancer stem cellsQ39328755
Virion-associated Vpr of human immunodeficiency virus type 1 triggers activation of apoptotic events and enhances fas-induced apoptosis in human T cellsQ39810780
Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrestQ39880367
Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cellsQ39884805
Viral complementation allows HIV-1 replication without integrationQ39963401
The vpr Regulatory Gene of HIVQ40467649
Long HIV type 1 reverse transcripts can accumulate stably within resting CD4+ T cells while short ones are degradedQ40513772
Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cellsQ40693187
HIV: Not-so-innocent bystandersQ40757266
Comparison of cell cycle arrest, transactivation, and apoptosis induced by the simian immunodeficiency virus SIVagm and human immunodeficiency virus type 1 vpr genes.Q40930626
Blood-Derived CD4 T Cells Naturally Resist Pyroptosis during Abortive HIV-1 InfectionQ40951821
Simultaneous three-color analysis of the surface phenotype and DNA-RNA quantitation using 7-amino-actinomycin D and pyronin Y.Q41335766
Induction of cell differentiation by human immunodeficiency virus 1 vpr.Q41572634
Detection of cell cycle subcompartments by flow cytometric estimation of DNA-RNA content in combination with dual-color immunofluorescenceQ41720055
Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cellsQ42759901
IL-7 enhances the survival and maintains the size of naive T cellsQ43819910
Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor.Q43944919
Induction of apoptosis by the Vpr protein of human immunodeficiency virus type 1 occurs independently of G(2) arrest of the cell cycleQ44306012
Involvement of HIV-1 protease in virus-induced cell killing.Q45084567
HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissuesQ46126584
Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells.Q53140150
Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4+ T CellsQ57075707
Interleukin-4 Inhibits Caspase-3 by Regulating Several Proteins in the Fas Pathway during Initial Stages of Human T Helper 2 Cell DifferentiationQ57655523
Cytokine regulation of apoptosis and Bcl-2 expression in lymphocytes of patients with systemic lupus erythematosusQ73695349
IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cellsQ77530670
A C-terminal domain of HIV-1 accessory protein Vpr is involved in penetration, mitochondrial dysfunction and apoptosis of human CD4+ lymphocytesQ79332330
Regulation of the tonsil cytokine milieu favors HIV susceptibilityQ80192651
Bystander T cell activation--implications for HIV infection and other diseasesQ80334939
P2507corrigendum / erratumErratum for Trinité et al., HIV-1 Vpr- and Reverse Transcription-Induced Apoptosis in Resting Peripheral Blood CD4 T Cells and Protection by Common Gamma-Chain CytokinesQ42356954
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)904-916
P577publication date2015-11-04
P1433published inJournal of VirologyQ1251128
P1476titleHIV-1 Vpr- and Reverse Transcription-Induced Apoptosis in Resting Peripheral Blood CD4 T Cells and Protection by Common Gamma-Chain Cytokines
P478volume90