Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein

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Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1047170197
P356DOI10.1038/GT.2012.61
P932PMC publication ID4105013
P698PubMed publication ID22895508

P2093author name stringN R Landau
N Sunseri
S Bobadilla
P2860cites workHow SAMHD1 changes our view of viral restrictionQ24605899
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by VpxQ24605940
Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemiaQ24618997
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesQ24624362
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 proteinQ24635842
Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor proteinQ24645706
Gene transfer in humans using a conditionally replicating lentiviral vectorQ24675343
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolaseQ27675416
A versatile viral system for expression and depletion of proteins in mammalian cellsQ28475909
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vectorQ29547503
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectorsQ29547596
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantationQ29615068
A third-generation lentivirus vector with a conditional packaging systemQ29616120
Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolaseQ29871440
Lentiviruses as gene transfer agents for delivery to non-dividing cellsQ34754954
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophyQ35011497
Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cellsQ35077587
Heterologous human immunodeficiency virus type 1 lentiviral vectors packaging a simian immunodeficiency virus-derived genome display a specific postentry transduction defect in dendritic cells.Q35803032
HER-2 pulsed dendritic cell vaccine can eliminate HER-2 expression and impact ductal carcinoma in situ.Q35899068
Regulatory considerations for novel gene therapy products: a review of the process leading to the first clinical lentiviral vectorQ36036225
Human immunodeficiency virus pseudotypes with expanded cellular and species tropismQ36806036
Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cellsQ36994727
A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif).Q37095343
Evidence for an activation domain at the amino terminus of simian immunodeficiency virus Vpx.Q38348781
Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virusQ39439883
The cargo-binding domain of transportin 3 is required for lentivirus nuclear importQ39462609
SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cellsQ40185026
With a little help from a friend: increasing HIV transduction of monocyte-derived dendritic cells with virion-like particles of SIV(MAC).Q40307361
Phenotypic mixing between human immunodeficiency virus and vesicular stomatitis virus or herpes simplex virusQ41753189
Chimeric Antigen Receptor Therapy for B-cell MalignanciesQ42766326
Gene therapy of x-linked adrenoleukodystrophy using hematopoietic stem cells and a lentiviral vectorQ42776697
Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trialQ43080246
Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequencesQ44491759
Repression of the human immunodeficiency virus type 1 promoter by the human KRAB domain results in inhibition of virus production.Q45749514
DCVax-Brain and DC vaccines in the treatment of GBMQ83589224
A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1-derived lentiviral vectorsQ84261542
P433issue5
P304page(s)514-520
P577publication date2012-08-16
P1433published inGene TherapyQ15763095
P1476titleEfficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein
P478volume20

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cites work (P2860)
Q39128552A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse
Q38693747A combination HIV reporter virus system for measuring post-entry event efficiency and viral outcome in primary CD4+ T cell subsets
Q34469817A nonintegrative lentiviral vector-based vaccine provides long-term sterile protection against malaria
Q61815216A novel splice mutation induces exon skipping of the EXT1 gene in patients with hereditary multiple exostoses
Q97529378Antiviral immunity and nucleic acid sensing in haematopoietic stem cell gene engineering
Q60306229Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells
Q38900861Degradation of SAMHD1 by Vpx Is Independent of Uncoating
Q44483910Dendritic cell immunotherapy
Q89347786Dendritic cell-based immunotherapy
Q36202747Differential regulatory activities of viral protein X for anti-viral efficacy of nucleos(t)ide reverse transcriptase inhibitors in monocyte-derived macrophages and activated CD4(+) T cells
Q55515225Efficient Transduction and Expansion of Ovine Macrophages for Gene Therapy Implementations.
Q37735112Efficient delivery of lentiviral vectors into resting human CD4 T cells
Q97644521Generation of Powerful Human Tolerogenic Dendritic Cells by Lentiviral-Mediated IL-10 Gene Transfer
Q37543254HIV type 1 infection of plasmacytoid and myeloid dendritic cells is restricted by high levels of SAMHD1 and cannot be counteracted by Vpx.
Q40922628HIV-1 Vpr- and Reverse Transcription-Induced Apoptosis in Resting Peripheral Blood CD4 T Cells and Protection by Common Gamma-Chain Cytokines
Q34795512Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells
Q94496792Human chimeric antigen receptor macrophages for cancer immunotherapy
Q24567990IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV
Q60913086Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection
Q30954229Intrinsic host restrictions to HIV-1 and mechanisms of viral escape.
Q92952368Lentiviral Vector-Based Dendritic Cell Vaccine Suppresses HIV Replication in Humanized Mice
Q96124007Lentiviral-Vector-Based Dendritic Cell Vaccine Synergizes with Checkpoint Blockade to Clear Chronic Viral Infection
Q35600854Macrophage-specific overexpression of interleukin-5 attenuates atherosclerosis in LDL receptor-deficient mice
Q26742169Recent Advances in Lentiviral Vaccines for HIV-1 Infection
Q35107612SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells
Q37350713The feasibility of incorporating Vpx into lentiviral gene therapy vectors.
Q56336950Toll-like receptor agonist R848 blocks Zika virus replication by inducing the antiviral protein viperin
Q92734574Vpr Enhances HIV-1 Env Processing and Virion Infectivity in Macrophages by Modulating TET2-Dependent IFITM3 Expression
Q89043272Vpr Targets TET2 for Degradation by CRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication
Q41347747Vpx-containing dendritic cell vaccine induces CTLs and reactivates latent HIV-1 in vitro

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