Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein

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Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.68.10.6161-6169.1994
P932PMC publication ID237035
P698PubMed publication ID8083957

P2093author name stringJ Kim
X Wu
J C Kappes
J A Conway
P2860cites workIdentification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virionsQ24645417
Human immunodeficiency virus vpr product is a virion-associated regulatory proteinQ24649600
Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymeraseQ27860943
VPX mutants of HIV-2 are infectious in established cell lines but display a severe defect in peripheral blood lymphocytesQ33563208
Monoclonal antibodies against human immunodeficiency virus (HIV) type 2 core proteins: cross-reactivity with HIV type 1 and simian immunodeficiency virusQ33649029
Gag proteins of the highly replicative MN strain of human immunodeficiency virus type 1: posttranslational modifications, proteolytic processings, and complete amino acid sequencesQ33930053
Evolution of the primate lentiviruses: evidence from vpx and vprQ33938392
The GAG precursor of simian immunodeficiency virus assembles into virus-like particlesQ34046090
Genome organization and transactivation of the human immunodeficiency virus type 2.Q34048704
Identification of HIV-1 vpr product and functionQ34168026
Human immunodeficiency virus-like particles produced by a vaccinia virus expression vectorQ34320065
A virion-specific inhibitory molecule with therapeutic potential for human immunodeficiency virus type 1Q36249990
Centrophilin: a novel mitotic spindle protein involved in microtubule nucleationQ36529167
Requirement of the Pr55gag precursor for incorporation of the Vpr product into human immunodeficiency virus type 1 viral particlesQ36630330
Vpx of simian immunodeficiency virus is localized primarily outside the virus core in mature virions.Q36650496
Human immunodeficiency virus type 1 viral protein R localization in infected cells and virionsQ36654319
Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis.Q36655127
Complete nucleotide sequence, genome organization, and biological properties of human immunodeficiency virus type 1 in vivo: evidence for limited defectiveness and complementationQ36685254
Dispensable role of the human immunodeficiency virus type 2 Vpx protein in viral replicationQ36701891
A mutant of human immunodeficiency virus with reduced RNA packaging and abnormal particle morphologyQ36784524
Molecular characterization of an attenuated human immunodeficiency virus type 2 isolateQ36801331
Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virusQ36804927
Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA.Q36809360
Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genesQ36843702
Identification of a novel retroviral gene unique to human immunodeficiency virus type 2 and simian immunodeficiency virus SIVMAC.Q36872683
Molecular characterization of gag proteins from simian immunodeficiency virus (SIVMne).Q36877852
Distinct signals in human immunodeficiency virus type 1 Pr55 necessary for RNA binding and particle formationQ38323895
RNA packaging signal of human immunodeficiency virus type 1Q38328360
Mutational analysis of the human immunodeficiency virus vpr open reading frame.Q40116997
HIV-2 viral protein X association with the GAG p27 capsid proteinQ41483290
Intracellular transport and virion incorporation of vpx requires interaction with other virus type-specific components.Q41570102
Human immunodeficiency virus type 2 vpx protein augments viral infectivityQ41667836
Human immunodeficiency virus vpr gene encodes a virion-associated proteinQ41716675
Production of human immunodeficiency virus (HIV)-like particles from cells infected with recombinant vaccinia viruses carrying the gag gene of HIVQ41743293
Assembly and release of HIV-1 precursor Pr55gag virus-like particles from recombinant baculovirus-infected insect cellsQ42073571
A naturally immunogenic virion-associated protein specific for HIV-2 and SIV.Q42649286
Isolation and characterization of a novel protein (X-ORF product) from SIV and HIV-2.Q42658314
Complete nucleotide sequences of functional clones of the AIDS virusQ45834378
Antibody response, recurrence patterns and subsequent herpes simplex virus type 2 (HSV-2) re-infection following initial HSV-2 infection of guinea-pigs: effects of acyclovirQ45836382
Origin of vpx in lentivirusesQ59096918
Form, function, and use of retroviral gag proteinsQ67961638
Analysis of retroviral assembly using a vaccinia/T7-polymerase complementation systemQ72967087
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectvirologyQ7215
P304page(s)6161-9
P577publication date1994-10-01
P1433published inJournal of VirologyQ1251128
P1476titleLocalization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein
P478volume68

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cites work (P2860)
Q39823471A cellular restriction dictates the permissivity of nondividing monocytes/macrophages to lentivirus and gammaretrovirus infection
Q35853370A conserved LXXLF sequence is the major determinant in p6gag required for the incorporation of human immunodeficiency virus type 1 Vpr.
Q33824939A conserved dileucine-containing motif in p6(gag) governs the particle association of Vpx and Vpr of simian immunodeficiency viruses SIV(mac) and SIV(agm)
Q45722171A non-canonical transferable signal mediates nuclear import of simian immunodeficiency virus Vpx protein.
Q50740512Analysis of HIV-2 Vpx by modeling and insertional mutagenesis.
Q36994727Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells
Q38900861Degradation of SAMHD1 by Vpx Is Independent of Uncoating
Q33926275Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein
Q36484010Evidence for Vpr-dependent HIV-1 replication in human CD4+ CEM.NKR T-cells
Q33834920Functional analysis of the simian immunodeficiency virus Vpx protein: identification of packaging determinants and a novel nuclear targeting domain.
Q34033122HIV accessory proteins: multifunctional components of a complex system.
Q35077587Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells
Q39581046Human immunodeficiency virus type 2 Vpx-Gag interaction.
Q34846363Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation
Q40148000Impact of viral accessory proteins of SIVsmmPBj on early steps of infection of quiescent cells
Q35895836Incorporation of functional human immunodeficiency virus type 1 integrase into virions independent of the Gag-Pol precursor protein.
Q38716281Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly
Q35860937Inhibition of human and simian immunodeficiency virus protease function by targeting Vpx-protease-mutant fusion protein into viral particles
Q33807088Interaction of human immunodeficiency virus type 2 Vpx and invariant chain
Q33639651Interaction with the p6 domain of the gag precursor mediates incorporation into virions of Vpr and Vpx proteins from primate lentiviruses
Q28472652Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection
Q37728096Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr?
Q35850945Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation.
Q24684633Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr
Q33783498Mutations of the human immunodeficiency virus type 1 p6Gag domain result in reduced retention of Pol proteins during virus assembly.
Q21131105New insights into an X-traordinary viral protein
Q33721523Nonstructural protein 5A is incorporated into hepatitis C virus low-density particle through interaction with core protein and microtubules during intracellular transport
Q35914698Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM).
Q35890940Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr.
Q24624362SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
Q24339547Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase
Q34438247Subunit-specific analysis of the human immunodeficiency virus type 1 reverse transcriptase in vivo.
Q35839628Targeting foreign proteins to human immunodeficiency virus particles via fusion with Vpr and Vpx.
Q39591808The C-terminal proline-rich tail of human immunodeficiency virus type 2 Vpx is necessary for nuclear localization of the viral preintegration complex in nondividing cells
Q40084910The poly-proline tail of SIVmac Vpx provides gain of function for resistance to a cryptic proteasome-dependent degradation pathway
Q41887927Variation of two primate lineage-specific residues in human SAMHD1 confers resistance to N terminus-targeted SIV Vpx proteins
Q40467618Viral Protein X
Q34338672Viral late domains
Q35888756Vpr of simian immunodeficiency virus of African green monkeys is required for replication in macaque macrophages and lymphocytes.
Q35859146Vpr-induced cell cycle arrest is conserved among primate lentiviruses.
Q35089155Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon
Q34288376p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease

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