| scholarly article | Q13442814 |
| P356 | DOI | 10.2337/DIAB.45.3.273 |
| P698 | PubMed publication ID | 8593930 |
| P50 | author | Barbara E. Corkey | Q39370280 |
| P2093 | author name string | Prentki M | |
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | obesity | Q12174 |
| P1104 | number of pages | 11 | |
| P304 | page(s) | 273-283 | |
| P577 | publication date | 1996-03-01 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Diabetes | Q895262 |
| P1476 | title | Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? | |
| P478 | volume | 45 |
| Q73797119 | A 13C Mass Isotopomer Study of Anaplerotic Pyruvate Carboxylation in Perfused Rat Hearts |
| Q42445285 | A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis |
| Q41035647 | A distinct difference in the metabolic stimulus–response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties |
| Q37382445 | A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion |
| Q28566987 | A single amino acid change (substitution of the conserved Glu-590 with alanine) in the C-terminal domain of rat liver carnitine palmitoyltransferase I increases its malonyl-CoA sensitivity close to that observed with the muscle isoform of the enzyme |
| Q34310675 | AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome |
| Q34993044 | Acetyl-CoA carboxylases 1 and 2 show distinct expression patterns in rats and humans and alterations in obesity and diabetes |
| Q40891351 | Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells). |
| Q35146102 | Acyl-CoA binding proteins interact with the acyl-CoA binding domain of mitochondrial carnitine palmitoyl transferase I |
| Q38211152 | Acyl-CoA metabolism and partitioning |
| Q28574337 | Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently |
| Q37412895 | Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome |
| Q28580422 | Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion |
| Q40386417 | Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro |
| Q43778772 | Antecedent Hyperglycemia, Not Hyperlipidemia, Is Associated With Increased Islet Triacylglycerol Content and Decreased Insulin Gene mRNA Level in Zucker Diabetic Fatty Rats |
| Q46881652 | Ascorbic Acid Is a Stimulatory Cofactor for Mitochondrial Glycerol-3-Phosphate Dehydrogenase |
| Q40837240 | Aspects of Novel Sites of Regulation of the Insulin Stimulus-Secretion Coupling in Normal and Diabetic Pancreatic Islets |
| Q35967957 | BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell |
| Q35612356 | Banting lecture 2011: hyperinsulinemia: cause or consequence? |
| Q42475368 | Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism |
| Q54590591 | Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling |
| Q37596131 | Beta-cell deterioration during diabetes: what's in the gun? |
| Q34996991 | Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities |
| Q34312182 | Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue |
| Q42505809 | Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose. |
| Q34808534 | Cardiac anaplerosis in health and disease: food for thought |
| Q35783124 | Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-Cells |
| Q27316876 | Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells |
| Q37378805 | Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation |
| Q28143067 | Cloning and expression of rat pancreatic beta-cell malonyl-CoA decarboxylase |
| Q35083749 | Contribution of SLC30A8 variants to the risk of type 2 diabetes in a multi-ethnic population: a case control study |
| Q35964119 | Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes |
| Q34579971 | Current understanding of feline diabetes: part 1, pathogenesis |
| Q28296650 | Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis |
| Q34030480 | Deacylation and reacylation of neural membrane glycerophospholipids |
| Q42150982 | Demonstration of N- and C-terminal domain intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity |
| Q34717309 | Desensitization of insulin secretion |
| Q41525373 | Dietary Fat and Human Obesity |
| Q37092809 | Differential modulation of L-type calcium channel subunits by oleate |
| Q38332272 | Dopamine agonist treatment ameliorates hyperglycemia, hyperlipidemia, and the elevated basal insulin release from islets of ob/ob mice |
| Q34743351 | Effects of free fatty acids on insulin secretion in obesity |
| Q42503904 | Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet |
| Q41885716 | Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate |
| Q28569627 | Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones |
| Q84415961 | Expression and genome polymorphism of ACSL1 gene in different pig breeds |
| Q41611242 | Fatty Acid Regulation of Gene Expression Its Role in Fuel Partitioning and Insulin Resistancea |
| Q35298758 | Fatty acid metabolism and insulin secretion in pancreatic beta cells |
| Q37381409 | Fatty acid-induced beta cell hypersensitivity to glucose. Increased phosphofructokinase activity and lowered glucose-6-phosphate content |
| Q73822379 | Fatty acids and beta-cell function |
| Q33320307 | Fatty acids and glucose in high concentration down-regulates ATP synthase beta-subunit protein expression in INS-1 cells |
| Q41133952 | Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1. |
| Q41888774 | Fibroblasts from type 1 diabetics exhibit enhanced Ca(2+) mobilization after TNF or fat exposure |
| Q42665692 | Functional Studies of Yeast-Expressed Human Heart Muscle Carnitine Palmitoyltransferase I |
| Q50335986 | Functional and structural basis of carnitine palmitoyltransferase 1A deficiency. |
| Q40068129 | Functional interaction between peroxisome proliferator-activated receptors-alpha and Mef-2C on human carnitine palmitoyltransferase 1beta (CPT1beta) gene activation |
| Q46417803 | Further evidence for the regulation of acetyl-CoA carboxylase activity by a glutamate- and magnesium-activated protein phosphatase in the pancreatic beta cell: defective regulation in the diabetic GK rat islet |
| Q42465299 | Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice |
| Q42156688 | Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets |
| Q38987013 | Glucagon-like peptide-1 analog-mediated protection against cholesterol-induced apoptosis via mammalian target of rapamycin activation in pancreatic βTC-6 cells -1mTORβTC-6. |
| Q40565084 | Glucagon-like peptide-1 prevents beta cell glucolipotoxicity |
| Q35762313 | Gluco-lipotoxicity of the pancreatic beta cell |
| Q34163947 | Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass |
| Q33665283 | Glucolipotoxicity of the pancreatic beta cell. |
| Q90099874 | Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes |
| Q36861036 | Glucolipotoxicity: fuel excess and beta-cell dysfunction. |
| Q42438470 | Glucose metabolism and glutamate analog acutely alkalinize pH of insulin secretory vesicles of pancreatic beta-cells. |
| Q43693174 | Glucose-induced metabolic oscillations parallel those of Ca(2+) and insulin release in clonal insulin-secreting cells. A multiwell approach to oscillatory cell behavior |
| Q37959707 | Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetes |
| Q48136474 | Heterogeneous long chain acyl-CoA synthetases control distribution of individual fatty acids in newly-formed glycerolipids of neuronal cells undergoing neurite outgrowth |
| Q35625609 | Hyperinsulinism in infancy: from basic science to clinical disease. |
| Q28345606 | Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion |
| Q74255562 | Hypoglycemic effects of a novel fatty acid oxidation inhibitor in rats and monkeys |
| Q28578477 | Identification by mutagenesis of conserved arginine and glutamate residues in the C-terminal domain of rat liver carnitine palmitoyltransferase I that are important for catalytic activity and malonyl-CoA sensitivity |
| Q73763134 | Identification by mutagenesis of conserved arginine and tryptophan residues in rat liver carnitine palmitoyltransferase I important for catalytic activity |
| Q38341682 | Impact of PPARgamma overexpression and activation on pancreatic islet gene expression profile analyzed with oligonucleotide microarrays |
| Q42809604 | Incorporation of [1-13C]oleate into cellular triglycerides in differentiating 3T3L1 cells |
| Q37641409 | Insulin release, peripheral insulin resistance and muscle function in protein malnutrition: a role of tricarboxylic acid cycle anaplerosis. |
| Q26866924 | Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetes |
| Q26829463 | Insulin resistance protects the heart from fuel overload in dysregulated metabolic states |
| Q51347839 | Insulin secretion is increased in non‐diabetic subjects with fasting hypertriglyceridaemia |
| Q37317469 | Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. |
| Q46084783 | Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass |
| Q34698810 | Islet beta cell failure in type 2 diabetes |
| Q33712562 | Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity |
| Q52709051 | Leptin Function and Regulation |
| Q37376534 | Leptin selectively decreases visceral adiposity and enhances insulin action. |
| Q41611262 | Lipid Abnormalities in Muscle of Insulin‐resistant Rodents The Malonyl CoA Hypothesisa |
| Q40929394 | Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells |
| Q28361455 | Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids |
| Q44739809 | Long-chain CoA esters activate human pancreatic beta-cell KATP channels: potential role in Type 2 diabetes |
| Q44653753 | Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance. |
| Q43252759 | Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes |
| Q38172884 | Macrophage-mediated glucolipotoxicity via myeloid-related protein 8/toll-like receptor 4 signaling in diabetic nephropathy |
| Q35584830 | Malonyl-CoA and AMP-activated protein kinase: an expanding partnership |
| Q28567580 | Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes |
| Q34379699 | Management of feline diabetes mellitus |
| Q46911659 | Meal composition affects insulin secretion in women with type 2 diabetes: a comparison with healthy controls. The Hoorn prandial study |
| Q28284068 | Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA |
| Q39386240 | Mediation of glucolipotoxicity in INS-1 rat insulinoma cells by small heterodimer partner interacting leucine zipper protein (SMILE) |
| Q35168513 | Metabolic and tissue-specific regulation of acyl-CoA metabolism. |
| Q38712872 | Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells. |
| Q44509849 | Metabolic partitioning of endogenous fatty acid in adipocytes |
| Q36461897 | Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. |
| Q37225252 | Minor role of mitochondrial respiration for fatty-acid induced insulin secretion |
| Q33886922 | Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells. |
| Q28609406 | Mobilisation of triacylglycerol stores |
| Q52530987 | Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis |
| Q28253454 | Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation: Inter-tissue and inter-species expression of CPT I and CPT II enzymes |
| Q92150101 | N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells |
| Q51921020 | NEFA-glucose comodulation model of beta-cell insulin secretion in 24-h multiple-meal test. |
| Q31895027 | Near-normoglycaemic remission in African-Americans with Type 2 diabetes mellitus is associated with recovery of beta cell function |
| Q34037472 | New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic beta-cells |
| Q34051199 | Nutrient toxicity in pancreatic beta-cell dysfunction |
| Q36775874 | Nutrigenomics, beta-cell function and type 2 diabetes |
| Q36071152 | Nutritional regulation of insulin secretion: implications for diabetes |
| Q35633777 | Ontogeny of mRNA expression and activity of long-chain acyl-CoA synthetase (ACSL) isoforms in Mus musculus heart |
| Q41989849 | Oscillations in oxygen consumption by permeabilized clonal pancreatic beta-cells (HIT) incubated in an oscillatory glycolyzing muscle extract: roles of free Ca2+, substrates, and the ATP/ADP ratio. |
| Q42156889 | Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). |
| Q40838108 | Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells |
| Q40279185 | Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo |
| Q44848265 | Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells |
| Q44456467 | Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis |
| Q44462823 | Palmitate modulates the early steps of insulin signalling pathway in pancreatic islets |
| Q37215509 | Pancreatic β-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity |
| Q43833555 | Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca2+] Elevation Signals |
| Q51555112 | Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle |
| Q43778791 | Plasma Free Fatty Acid Uptake and Oxidation Are Already Diminished in Subjects at High Risk for Developing Type 2 Diabetes |
| Q33964745 | Polyunsaturated fatty acid regulation of gene transcription: a mechanism to improve energy balance and insulin resistance. |
| Q33798851 | Present and future studies on lipogenesis in animals and human subjects |
| Q44138388 | Probing the link between citrate and malonyl-CoA in perfused rat hearts |
| Q40211094 | Prolonged exposure to homocysteine results in diminished but reversible pancreatic beta-cell responsiveness to insulinotropic agents |
| Q34137563 | Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol |
| Q42996947 | Reconstitution of purified, active and malonyl-CoA-sensitive rat liver carnitine palmitoyltransferase I: relationship between membrane environment and malonyl-CoA sensitivity |
| Q46750263 | Regulation of acetyl CoA carboxylase and carnitine palmitoyl transferase-1 in rat adipocytes |
| Q37603286 | Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes |
| Q46642898 | Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes |
| Q41917006 | Regulation of pancreatic beta-cell mitochondrial metabolism: influence of Ca2+, substrate and ADP. |
| Q54151747 | Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653 |
| Q24530119 | Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling |
| Q35168497 | Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis |
| Q35667288 | Roles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity |
| Q44660894 | Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion. |
| Q40162688 | Stevioside improves pancreatic beta-cell function during glucotoxicity via regulation of acetyl-CoA carboxylase |
| Q42761408 | Stimulation of Lipogenesis as Well as Fatty Acid Oxidation Protects against Palmitate-Induced INS-1 β-Cell Death |
| Q28564300 | Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain |
| Q37798716 | Systemic effects of white adipose tissue dysregulation and obesity-related inflammation |
| Q35045905 | Taking pressure off the heart: the ins and outs of atrophic remodelling |
| Q43004895 | The Battered β-Cell: Usual Suspects and Guilt by Association |
| Q39052399 | The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes |
| Q92635526 | The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment |
| Q28577659 | The extreme C terminus of rat liver carnitine palmitoyltransferase I is not involved in malonyl-CoA sensitivity but in initial protein folding |
| Q33755073 | The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function |
| Q37936117 | The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles? |
| Q34445035 | Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity |
| Q28579497 | Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane |
| Q24530177 | Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA |
| Q46610477 | Twenty-four hour insulin secretion and beta cell NEFA oxidation in type 2 diabetic, morbidly obese patients before and after bariatric surgery. |
| Q29617184 | Type 2 diabetes as an inflammatory disease |
| Q44082654 | beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats |
| Q42490543 | beta-cell adaptation in 60% pancreatectomy rats that preserves normoinsulinemia and normoglycemia |
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