Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch Syndrome).

scientific article published on February 1996

Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch Syndrome). is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1002/(SICI)1097-0215(19960220)69:1<38::AID-IJC9>3.0.CO;2-X
P698PubMed publication ID8600057

P2093author name stringH T Lynch
T Smyrk
J F Lynch
P2860cites workUbiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesisQ22122362
Mutations of two PMS homologues in hereditary nonpolyposis colon cancerQ24318484
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancerQ28257360
Genetic mapping of a locus predisposing to human colorectal cancerQ28268634
Microsatellite instability in cancer of the proximal colonQ29620692
Predictors of presence, multiplicity, size and dysplasia of colorectal adenomas. A necropsy study in New ZealandQ34396275
The molecular basis of Turcot's syndromeQ34662365
Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study WorkgroupQ34728738
Randomized comparison of surveillance intervals after colonoscopic removal of newly diagnosed adenomatous polyps. The National Polyp Study Workgroup.Q34730621
Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer familiesQ35550036
Cancer risk notification: psychosocial and ethical implicationsQ37748645
Genetic instability occurs in the majority of young patients with colorectal cancerQ38297232
Participation in fecal occult blood screening: a critical reviewQ39759318
Psychological aspects of genetic counseling: a legal perspectiveQ40678880
Common inheritance of susceptibility to colonic adenomatous polyps and associated colorectal cancersQ41336230
Natural history of hereditary cancer of the breast and colonQ41457494
Clues to the pathogenesis of familial colorectal cancerQ42622043
The psychological consequences of predictive testing for Huntington's disease. Canadian Collaborative Study of Predictive TestingQ44363828
Predictive testing for Huntington disease in Canada: adverse effects and unexpected results in those receiving a decreased riskQ45292147
Predictive testing for Huntington disease: are we ready for widespread community implementation?Q45293400
Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformationQ46049171
Alleles of the APC gene: an attenuated form of familial polyposisQ48088124
Clinical features of colorectal carcinoma in cancer family syndrome.Q50577948
Mammography adherence and psychological distress among women at risk for breast cancer.Q50609636
Psychological Distress and Surveillance Behaviors of Women With a Family History of Breast CancerQ51153527
Differential diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome I and Lynch syndrome II)Q54533144
Frequency of hereditary nonpolyposis colorectal cancer. A prospective multicenter study in Finland.Q54610991
Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancerQ58862199
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmolecular geneticsQ210506
Lynch syndromeQ783644
P1104number of pages6
P304page(s)38-43
P577publication date1996-02-01
P1433published inInternational Journal of CancerQ332492
P1476titleOverview of natural history, pathology, molecular genetics and management of HNPCC (Lynch Syndrome).
P478volume69

Reverse relations

cites work (P2860)
Q33685993A practical approach to familial and hereditary colorectal cancer
Q34067753Approaching the adnexal mass in the new millennium
Q35079926BRCA2 and pancreatic cancer
Q36084326Biomarkers in endometrial cancer: Possible clinical applications (Review)
Q61917173Cancer risk and overall survival in mismatch repair proficient hereditary non-polyposis colorectal cancer, Lynch syndrome and sporadic colorectal cancer
Q42134566Choice of management strategy for colorectal cancer based on a diagnostic immunohistochemical test for defective mismatch repair
Q52893411DNA mismatch repair in lymphoblastoid cells from hereditary non-polyposis colorectal cancer (HNPCC) patients is normal under conditions of rapid cell division and increased mutational load.
Q41536289DNA mismatch repair in mammals: role in disease and meiosis
Q48682503Disease expression in Swiss hereditary non-polyposis colorectal cancer (HNPCC) kindreds
Q34615912Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability
Q33839135Epidemiology and molecular genetics of colorectal cancer
Q77924565Epithelial ovarian cancer
Q36421123Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents
Q89849938Expanding the Scope of Immunotherapy in Colorectal Cancer: Current Clinical Approaches and Future Directions
Q36641429Extensive molecular screening for hereditary non-polyposis colorectal cancer
Q41955895FAP: another indication to treat H pylori
Q36294972Family history of cancer and risk of colorectal cancer in Italy
Q57560315Family history of cancer and risk of ovarian cancer
Q35840995Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas
Q36318595From gene mutations to tumours--stem cells in gastrointestinal carcinogenesis.
Q47713981Functional analysis of human MLH1 mutations in Saccharomyces cerevisiae
Q36672157Gastrointestinal stem cells and cancer: bridging the molecular gap.
Q35034265Genetic testing for colon cancer: joint statement of the American College of Medical Genetics and American Society of Human Genetics. Joint Test and Technology Transfer Committee Working Group
Q35810149Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: A newly described and characterized entity
Q43869182Germ cells microsatellite instability. The effect of different mutagens in a mismatch repair mutant of Drosophila (spel1).
Q42005199Germline HNPCC gene variants have little influence on the risk for sporadic colorectal cancer
Q52551102Germline mutations at microsatellite loci in homozygous and heterozygous mutants for mismatch repair and PCNA genes in Drosophila.
Q53600496How cancer gene testing can benefit patients.
Q40762811Identification and functional characterization of the promoter region of the human MSH6 gene
Q57742300Inherited susceptibility to colorectal adenomas and carcinomas: Evidence for a new predisposition gene on 15q14-q22
Q79156469Laparoscopic prophylactic surgery for HNPCC gene mutation carrier: has the time come?
Q28131788Lessons from hereditary colorectal cancer
Q43235852Macrocyclic DNA-mismatch-binding ligands: structural determinants of selectivity
Q36660380Microsatellite instability status in gastric cancer: a reappraisal of its clinical significance and relationship with mucin phenotypes
Q36618286Microsatellite instability, Epstein-Barr virus, mutation of type II transforming growth factor beta receptor and BAX in gastric carcinomas in Hong Kong Chinese
Q26764919Molecular alterations in gastric cancer with special reference to the early-onset subtype
Q33540554Molecular genetics of gastrointestinal malignancies
Q33368199Molecular pathogenesis of colorectal cancer
Q36325598Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation
Q36417805Mutational targets in colorectal cancer cells with microsatellite instability.
Q33347546Nature meets nurture: molecular genetics of gastric cancer.
Q38114502Novel drug discovery opportunities for colorectal cancer
Q58695957Novel genetic mutations detected by multigene panel are associated with hereditary colorectal cancer predisposition
Q33955335PCR-detected genome polymorphism in malignant cell growth
Q35765148Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+
Q35594437Pathogenicity of missense and splice site mutations in hMSH2 and hMLH1 mismatch repair genes: implications for genetic testing
Q36404900Pathologic predictors of microsatellite instability in colorectal cancer
Q34102606Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study
Q41563180Preoperative and postoperative imaging for colorectal cancer
Q33493198Presence of activating KRAS mutations correlates significantly with expression of tumour suppressor genes DCN and TPM1 in colorectal cancer
Q38558424Psychological opportunities and hazards in predictive genetic testing for cancer risk
Q33644845Public health perspectives on testing for colorectal cancer susceptibility genes
Q39370829Rapid Disease Progression of Liver Metastases following Resection in a Liver-Transplanted Patient with Probable Lynch Syndrome - A Case Report and Review of the Literature
Q37194503Recurrent gene fusions in prostate cancer
Q35875374Risk assessment and screening for colorectal cancer.
Q33789374Screening for colorectal carcinoma
Q52548942Spontaneous and bleomycin-induced genomic alterations in the progeny of Drosophila treated males depends on the Msh2 status. DNA fingerprinting analysis.
Q57240725The Labyrinthine Ways of Cancer Immunotherapy–T Cell, Tumor Cell Encounter: “How Do I Lose Thee? Let Me Count the Ways”
Q30427620The adenomatous polyposis coli (APC) tumor suppressor
Q41736390The role of microsatellite instability in gastric carcinoma
Q44265811The role of religious and existential well-being in families with Lynch syndrome: prevention, family communication, and psychosocial adjustment
Q60709620Transcriptional regulation of the mismatch repair gene hMLH1
Q77495206Transcripts with splicings of exons 15 and 16 of the hMLH1 gene in normal lymphocytes: implications in RNA-based mutation screening of hereditary non-polyposis colorectal cancer
Q81084150[Clinical guidelines for the prevention of colorectal cancer]
Q80075929[Molecular pathology in hereditary colorectal cancer. Recommendations of the Collaborative German Study Group on hereditary colorectal cancer funded by the German Cancer Aid (Deutsche Krebshilfe)]

Search more.